Secretory immunoglobulin A in tears: functions and changes during contact lens wear

Willcox, Mark; Lan, J

doi:10.1111/j.1444-0938.1999.tb06777.x

Cited by 35 publications

(13 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…16 It has been speculated that potential mechanisms of CL-related dry eye include increased evaporation of the tear film, ocular surface inflammation, reduced ability to produce adequate tears with concurrent increase in tear osmolarity, dewetting related to lack of biocompatibility of the lens surface, or any combination of these. [17][18][19][20][21][22][23][24][25][26][27] The true etiology of CL-related dry eye remains elusive. We believe that successful CL wear depends on a stable tear film, including the production and maintenance in each of its layers.…”

Section: Discussionmentioning

confidence: 99%

Passive Cigarette Smoke Exposure and Soft Contact Lens Wear

Ward¹,

Doğru²,

Wakamatsu³

et al. 2010

Optometry and Vision Science

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Passive Cigarette Smoke Exposure and Soft Contact Lens Wear

Ward¹,

Doğru²,

Wakamatsu³

et al. 2010

Optometry and Vision Science

View full text Add to dashboard Cite

show abstract

“…156 Contact lens-wear decreases the levels of sIgA in tear fluid, 157 and extended wear of contact lenses, which is associated with a greater risk of corneal infections, also decreases tear concentrations of sIgA epitopes. 158 It can be hypothesized that decreased levels of sIgA inhibits proper modulation of ocular surface flora, whereby pathogenic/opportunistic organisms colonize the ocular surface.…”

Section: Dry Eye Innate Immune System and Endogenous Antimicrobmentioning

confidence: 99%

Dry Eye Disease and Microbial Keratitis: Is There a Connection?

Narayanan¹,

Redfern²,

Miller³

et al. 2013

The Ocular Surface

View full text Add to dashboard Cite

Dry eye is a common ocular surface disease of multifactorial etiology characterized by elevated tear osmolality and inflammation leading to a disrupted ocular surface. The latter is a risk factor for ocular surface infection, yet overt infection is not commonly seen clinically in the typical dry eye patient. This suggests that important innate mechanisms operate to protect the dry eye from invading pathogens. This article reviews the current literature on epidemiology of ocular surface infection in dry eye patients and laboratory-based studies on innate immune mechanisms operating at the ocular surface and their alterations in human dry eye and animal models. The review highlights current understanding of innate immunity in dry eye and identifies gaps in our knowledge to help direct future studies to further unravel the complexities of dry eye disease and its sequelae.

show abstract

“…It has been suggested that potential mechanisms of contact lens-related dry eye include increased evaporation of the tear film15, inflammation16–18, reduced ability to produce adequate tears with concurrent increased osmolality19, 20, dewetting related to lack of biocompatibility of the lens surface21–25, or any above mentioned combination. In the current study’s cohort, we previously reported that high water content contact lenses, rapid pre-lens tear film thinning, limbal injection, and an increased tear film osmolality were significant factors associated with contact lens-related dry eye 26.…”

mentioning

confidence: 99%

Treatment, Material, Care, and Patient-related Factors in Contact Lens-Related Dry Eye

Ramamoorthy

Sinnott

Nichols

2008

Optometry and Vision Science

View full text Add to dashboard Cite

PURPOSE To examine the effect of general contact lens and material characteristics, care solutions, treatment and patient-related factors on contact lens-related dry eye. METHODS The data were derived from the Contact Lens and Dry Eye Study, designed as a cross-sectional and nested case-control study including 360 subjects. In separate statistical models, logistic regression was used to examine general contact lens characteristics, specific hydrogel lens materials, care solutions, and patient-related factors associated with dry eye status (controlled for age, gender, and current treatments). RESULTS Several factors were significantly associated with dry eye, including treatment factors such as a recent contact lens refitting (OR = 5.75, 95% CI = 2.14 to 15.46) and use of artificial tears/rewetting drops (OR = 1.09, 95% CI = 1.02 to 1.16), and currently worn materials including FDA group II (OR = 2.98, 95% CI = 1.14 to 6.19) and IV (OR = 1.87, 95% CI = 1.08 to 3.24). Significant patient-related factors included decreased overall satisfaction (OR = 3.57, 95% CI = 2.08 to 5.88,), dry eye in the absence of contact lens wear (OR = 6.54, 95% CI = 2.57 to 16.62), reduced daily lens wear duration (OR = 1.16, 95% CI = 1.06 to 1.26), and reduced ability to wear lenses as long as desired (OR = 2.44, 95% CI = 1.30 to 4.54). Care solutions were not significant. CONCLUSIONS The strong association of common treatment factors with dry eye status in contact lens wearers suggests that these treatments are not entirely effective. The use of high water content materials was strongly related to dry eye in lens wearers, while care solutions were not. Contact lens-related dry eye was also associated with several patient-related factors such as greater ocular discomfort (without lenses), dissatisfaction, and inability to wear lenses for desired durations.

show abstract

Secretory immunoglobulin A in tears: functions and changes during contact lens wear

Cited by 35 publications

References 5 publications

Passive Cigarette Smoke Exposure and Soft Contact Lens Wear

Passive Cigarette Smoke Exposure and Soft Contact Lens Wear

Dry Eye Disease and Microbial Keratitis: Is There a Connection?

Treatment, Material, Care, and Patient-related Factors in Contact Lens-Related Dry Eye

Contact Info

Product

Resources

About