SECRETORY IgA ANTIBODY TO ROTAVIRUS IN HUMAN MILK 6-9 MONTHS POSTPARTUM

Cukor, George; Blacklow, Neil R.; Panjvani, Z; Bednarek, Frank

doi:10.1016/s0140-6736(78)92853-2

Cited by 14 publications

(1 citation statement)

References 6 publications

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“…More detailed studies later showed that the antiviral properties were associated with antibody (Sabin and Fieldsteel [ 19621 ;Michaels 119651). Neutralizing activity against Coxsackie and echo viruses was also reported [Michaels, 19651. In addition, rotavirus antibody has been found in milk and colostrum [Simhon and Mata, 1978;Yolken et al, 1978;Cukor et al, 1979;Inglis et al, 1978;Cook c l al, 19781, as has antibody t o some alphaviruses [Welsh et al, 19761. sure virus-specific IgA and IgC in paired human serum and colostrum. The ELISA and neutralization test were used t o confirm and extend recent findings that indicate that colostrum contains enteric virus secretory antibody directed against viruses excreted via the gastrointestinal tract.…”

Section: Introductionmentioning

confidence: 99%

Antiviral activity of colostrum and serum immunoglobulins a and g

Palmer¹,

Gary²,

Black³

et al. 1980

Journal of Medical Virology

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Enteric virus-specific IgA and IgG present in paired human sera and colostrums were measured by the enzyme-linked immunosorbent assay (ELISA). Virus-specific IgA was present in all colostrums, but virus-specific IgG could not be detected. The reverse was true when sera were assayed. Most of these colostrums also neutralized either polio virus or reovirus, as did IgA, which was separated from a pool of colostrums by exclusion chromatography. No correlation could be made between levels of neutralizing and ELISA antibody titers in colostrums.

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Section: Introductionmentioning

confidence: 99%

Antiviral activity of colostrum and serum immunoglobulins a and g

Palmer¹,

Gary²,

Black³

et al. 1980

Journal of Medical Virology

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Secretion of respiratory syncytial virus inhibitors and antibody in human milk throughout lactation

et al. 1980

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Neutralising inhibitors to respiratory syncytial (RS) virus have been demonstrated in the whey of most samples of human milk tested. Although high titres were secreted in colostra of some mothers (1/10-1/2,560; median 1/40) inhibitor levels in milk collected after the first week of lactation were uniformly low (median 1/10). High neutralising titres correlated with high colostral levels of specific antiviral IgA but, unlike neutralising activity, IgA antiviral antibody persisted in the milk of only four of 18 mothers. Similarly, antiviral IgG and IgM antibodies were not generally detected after the first post-partum week. Differences in antibody secretion among mothers did not correlate with differences in total protein or total immunoglobulin secretion, and appeared to reflect maternal immune status. In one mother a marked rise in specific antiviral IgA and IgG secretions during the second and third months of lactation suggested a response to virus infection. The relevance of maternal immunity and colostral and milk antiviral antibody to protection of breast-fed babies from RS-virus bronchiolitis is discussed.

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