Association of Human Milk SIgA Antibodies with Maternal Intestinal Exposure to Microbial Antigens

Cruz, J. R.; Cano, Floridalma; Cáceres, Patricia

doi:10.1007/978-1-4615-3838-7_25

Cited by 12 publications

(3 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since secretory immunoglobulin A antibodies to CFs and enterotoxin are present in breast milk samples from mothers in developing countries (39,84,187), it would be natural to assume that breastfed infants should be protected from ETEC diarrhea. However, epidemiological studies show that partial breast feeding does not result in a reduced risk of ETEC diarrhea.…”

Section: Etec Infections and Malnutritionmentioning

confidence: 99%

Enterotoxigenic Escherichia coli in Developing Countries: Epidemiology, Microbiology, Clinical Features, Treatment, and Prevention

et al. 2005

View full text Add to dashboard Cite

ETEC is an underrecognized but extremely important cause of diarrhea in the developing world where there is inadequate clean water and poor sanitation. It is the most frequent bacterial cause of diarrhea in children and adults living in these areas and also the most common cause of traveler's diarrhea. ETEC diarrhea is most frequently seen in children, suggesting that a protective immune response occurs with age. The pathogenesis of ETEC-induced diarrhea is similar to that of cholera and includes the production of enterotoxins and colonization factors. The clinical symptoms of ETEC infection can range from mild diarrhea to a severe cholera-like syndrome. The effective treatment of ETEC diarrhea by rehydration is similar to treatment for cholera, but antibiotics are not used routinely for treatment except in traveler's diarrhea. The frequency and characterization of ETEC on a worldwide scale are inadequate because of the difficulty in recognizing the organisms; no simple diagnostic tests are presently available. Protection strategies, as for other enteric infections, include improvements in hygiene and development of effective vaccines. Increases in antimicrobial resistance will dictate the drugs used for the treatment of traveler's diarrhea. Efforts need to be made to improve our understanding of the worldwide importance of ETEC

show abstract

Section: Etec Infections and Malnutritionmentioning

confidence: 99%

Enterotoxigenic Escherichia coli in Developing Countries: Epidemiology, Microbiology, Clinical Features, Treatment, and Prevention

et al. 2005

View full text Add to dashboard Cite

show abstract

“…Most prominent among these is the lactating mammary gland. SIgA is the major Ig of colostrum and milk from many mammalian species, where it contributes to passive immunity of the suckling young (Bienenstock and Strauss, 1970;Lamm and Greenberg, 1972;Pahud and Mach, 1972;Nagura et al, 1978;Hanson, 1982;Brandtzaeg, 1983b;Sheldrake et al, 1984;Hahn-Zoric et al, 1989;Cruz et al, 1991;Hayani et al, 1991;Goldblum and Goldman, 1994;Giugliano et al, 1995;Rosato et al, 1995;Demmer, 1999, 2000;Kumura et al, 2000;van der Feltz et al, 2001;Taylor et al, 2002;Rincheval-Arnold et al, 2002b). As described above (see previous section, Transport of Polymeric Ig by the Polymeric Ig Receptor), an early study of allotype markers in colostral IgA of rabbits provided direct evidence for local assembly of SIgA in the mammary gland (Lawton and Mage, 1969).…”

Section: Tissue-specific Expression Of Pigrmentioning

confidence: 97%

Immunoglobulin Transport and Immunoglobulin Receptors

2015

View full text Add to dashboard Cite

“…IgA is the predominant immunoglobulin in human milk and its presence reflects prior exposure of the mother to immunogenic stimuli (Hanson et al, 1984). Therefore, two mothers at similar lactational stage could well be secreting immunoglobulins in breast milk with varying levels of antibody activity to the same bacterial strains (Cruz et al, 1991). In general, the level of total IgA content of human milk samples was not necessarily correlated with the level of specific activity against different pathogens.…”

Section: Antibody Activity Of Human Milk Iga Against Lps Fractions Frmentioning

confidence: 98%

Detection of antibody specificity of raw bovine and human milk to bacterial lipopolysaccharides using PCFIA

Losso

Dhar

Kummer

et al. 1993

Food and Agricultural Immunology

View full text Add to dashboard Cite

Raw milk from non-immunized cows and raw human milk from lactating mothers were examined for specificity and antibody activity against lipopolysaccharides (LPS) of five pathogenic bacteria, i.e. Escherichia coli O111:B4, E. coli O128:B12, Salmonella enteritidis, S. typhimurium and Shigella flexneri 1A in a particle concentration fluorescence immunoassay (PCFIA). Bacterial LPS was covalently coated on submicron polystyrene particles and used in an antibody sandwich technique with commercially available rabbit anti-bovine fluorescein-labeled IgG or goat anti-human fluorescein-labeled IgA. Comparison was made to a skim milk sample obtained from vaccinated cows. In general, specific activity of milk IgG against bacterial LPS did not parallel the trend of total non-specific activity. Although the specific anti-LPS activities were in general high in milk from vaccinated cows, milk from non-immunized cows also showed significant activity against the bacterial LPS, sometimes higher than the vaccinated cows. IgA in human milk samples showed a wider range of antibody activity against the LPS fractions than bovine milk samples. The specificity of antibody from milk obtained from non-immunized cows against pathogenic bacteria demonstrated that immunization of cows in order to obtain milk with high titer antibody may not be necessary as milk from non-immunized cows can provide IgG with sufficient antibody activity against the LPS of bacterial pathogens. This can translate into significant savings and reduce stress imposed on animals for immunization.

show abstract

Association of Human Milk SIgA Antibodies with Maternal Intestinal Exposure to Microbial Antigens

Cited by 12 publications

References 25 publications

Enterotoxigenic Escherichia coli in Developing Countries: Epidemiology, Microbiology, Clinical Features, Treatment, and Prevention

Enterotoxigenic Escherichia coli in Developing Countries: Epidemiology, Microbiology, Clinical Features, Treatment, and Prevention

Immunoglobulin Transport and Immunoglobulin Receptors

Detection of antibody specificity of raw bovine and human milk to bacterial lipopolysaccharides using PCFIA

Contact Info

Product

Resources

About