“…In addition, two double blind, controlled trials have failed to show any substantial benefit from the use of antibiotics (Mygind et al, 1981;Van Buchem et al, 1981). It has also been suggested that the use of antibiotics for acute otitis media may promote the development of chronic middle-ear effusions (Tremble, 1951;Schenk, 1953;Woodward, 1956;Thompson, 1963;Mills et al, 1984). Thus, abandoning the use of antibiotic therapy for otitis media has been suggested by some investigators (Mygind et al, 1981).…”