Secretory Carcinoma of the Breast

Amott, Deborah; Masters, Rick; Moore, Suzanne

doi:10.1111/j.1075-122x.2006.00233.x

Cited by 18 publications

(11 citation statements)

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“…Some consider that there is insufficient evidence to justify recommending these modalities [23,37,78,107]. However, in adults, others recommend adjuvant radiation following breastconserving surgery, in line with guidelines for other breast cancer histologies [38,109]. In children, there are concerns about long-term toxicity and adjuvant radiation is not recommended [39].…”

Section: Secretory Breast Cancermentioning

confidence: 99%

Management of Unusual Histological Types of Breast Cancer

et al. 2012

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There is increased understanding of the heterogeneity of breast tumors, with greater emphasis now being placed on histological and molecular profiles and, in particular, their implications for prognosis and therapy. This review addresses breast cancers of unusual histological subtype with an approximate incidence <1%. Given the rarity of these tumors, the literature contains primarily case reports, small series, and population-based studies. Data are heterogeneous and almost entirely retrospective, frequently gathered over long time periods, in the context of changing pathological techniques and reporting. In addition, our understanding of the disease biology and therapeutic context has also evolved significantly over this time. There is often limited information about the specific therapies used and the rationale for choosing such an approach. Meaningful comparisons of treatment modalities are not feasible and it is not possible to define management guidelines. Instead, this review correlates the available information to give an impression of how each subgroup behaves-of the favored surgical technique, responses to therapy, and prognosis-as well as the emerging molecular data, highlighting new research areas for potential target in clinical trials. Each tumor subtype described represents a small but real cohort of patients with breast cancer, and although inferences may be made from this review, we are mindful of the paucity of data. The management of each patient must be considered in the context of their unique clinical presentation and correlated with the evidence-based principles that apply to more common breast cancer histologies. The Oncologist 2012;17:1135-1145

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Section: Secretory Breast Cancermentioning

confidence: 99%

Management of Unusual Histological Types of Breast Cancer

et al. 2012

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“…In contrast to invasive ductal carcinoma, not otherwise specified, secretory carcinoma does not usually present as a distinctly spiculated lesion but rather as a discrete, lobulated, solitary mass with smooth or irregular borders, which may mimic a fibroadenoma. 16 Nonpalpable lesions may present as asymmetric densities or rarely, microcalcifications. Because secretory carcinomas occur more frequently in young women, mammography may have a diagnostic limitation because of the relatively high density of the breast tissue.…”

Section: Radiologic Featuresmentioning

confidence: 99%

Secretory Breast Carcinoma: Unique, Triple-Negative Carcinoma With a Favorable Prognosis and Characteristic Molecular Expression

Vasudev

Onuma²

2011

Archives of Pathology &Amp; Laboratory Medicine

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Secretory carcinoma is a rare but distinct subtype of breast carcinoma, with characteristic histomorphology and generally favorable prognosis. Although it was originally described as a juvenile breast carcinoma, occurring in young children, most cases have been reported in adults of both sexes. As the name implies, the characteristic histomorphology is the presence of a large amount of intracellular and extracellular, eosinophilic secretion material that stains positive for periodic acid–Schiff. Most tumors stain positive for S100 and negative for estrogen receptor, progesterone receptor, and ERBB2 (formerly HER2/neu) (ie, triple negative). In addition, some secretory carcinomas demonstrate a basal-like immunoprofile. Recent studies have shown the characteristic molecular feature: a balanced translocation t(12;15), resulting in an ETS variant 6–neurotrophic tyrosine kinase receptor type 3 (ETV6-NTRK3) fusion gene encoding a chimeric tyrosine kinase. Although rare events of axillary lymph node or distant metastases have been documented, the prognosis is generally excellent. The methods of surgical treatment and the role of adjuvant therapy, particularly for young patients, remain controversial.

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“…Because SBC occurs more frequently in young woman, mammography may have a diagnostic limitation because of the relatively high density of the breast tissue. A retroareolar dense mass is the usual finding in children as well as in male patients [12][13][14] .…”

Section: Discussionmentioning

confidence: 99%

Secretory breast carcinoma in adulthood: A case report with literature review

et al. 2020

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Introduction. Secretory breast carcinoma is rare subtype of breast carcinoma which occurs primarily in children and young adults, so in the past it was called juvenile carcinoma. Case report. A 67-year-old female patient presented with mass of the right breast since one month. After physical, routine laboratory examination and mammography, core needle biopsy was performed and histopathological examination confirmed invasive carcinoma. Immunohistochemically, estrogen-receptors (ER) and progesteron-receptors (PR) showed weak positive reaction in 10% of tumor cells, while human epidermal growth factor receptor-2 (HER-2) was without expression. After an adequate preoperative preparation, operation was done -quadrantectomy with sentinel lymph node biopsy. Postoperatively, the patient was treated with 6 cycles of cyclophosphamide, methotrexate and fluorouracil (CMF) combination, radiotherapy (60 Gy) and tamoxifen. After 5-year follow-up the patient had no signs of the disease. Conclusion. Secretory breast cancer is a rare subtype of invasive breast carcinoma with wide age range of occurrence and good prognosis despite its triplenegative immunophenotype. Although the therapeutic management is non-consensual for this breast cancer special type, surgery is considered the mainstay of the treatment as well as the adjuvant chemotherapy and radiation.Key words: breast neoplasms; secretory breast carcinoma; triple negative breast neoplasms; diagnosis; mastectomy, segmental; adult. ApstraktUvod. Sekretorni karcinom dojke je redak tip karcinoma dojke koji se prvenstveno javlja kod dece i mlađih odraslih osoba, zbog čega se u prošlosti nazivao juvenilnim karcinomom. Prikaz bolesnika. Žena, starosti 67 godina, javila se zbog palpabilne, bezbolne mase u desnoj dojci, koja se javila mesec dana pre prijema. Nakon fizikalnog pregleda, rutinskih laboratorijskih analiza i mamografije, načinjena je iglena biopsija i patohistološkom analizom dijagnostikovan je invazivni karcinom dojke. Imunohistohemijski, 10% tumorskih ćelija je pokazalo slabu pozitivnost na estrogenske i progesteronske receptore, dok je receptor humanog epidermalnog faktora rasta-2 (HER-2) bio negativan. Posle adekvatne preoperativne pripreme, izvršen je opertivni zahvatkvadrantektomija sa biopsijom limfnog čvora stražara. Postoperativno, bolesnik je tertiran kombinacijom ciklofosfamid/metrotreksat/fluorouracil (6 ciklusa), radioterapijom (60 Gy) i tamoksifenom. Petogodišnjim praćenjem bolesnice nisu ustanovljeni znaci bolesti. Zaključak. Sekretorni karcinom dojke je redak tip karcinoma dojke, koji zahvata sve starosne grupe i ima dobru prognozu bez obzira na karakteristični tripl-negativni fenotip. Iako ne postoji standardizovan protokol lečenja, hirurška resekcija uz adjuvantnu hemoterapiju i zračnu terapiju su glavni terapijski postupci za ovaj tip karcinoma dojke.

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Secretory Carcinoma of the Breast

Cited by 18 publications

References 0 publications

Management of Unusual Histological Types of Breast Cancer

Management of Unusual Histological Types of Breast Cancer

Secretory Breast Carcinoma: Unique, Triple-Negative Carcinoma With a Favorable Prognosis and Characteristic Molecular Expression

Secretory breast carcinoma in adulthood: A case report with literature review

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