Secretion of ghrelin from rat stomach ghrelin cells in response to local microinfusion of candidate messenger compounds: A microdialysis study

Cour, Charlotta Dornonville de la; Norlén, Per; Håkanson, R.

doi:10.1016/j.regpep.2007.05.001

Cited by 76 publications

(78 citation statements)

References 71 publications

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“…3 and 4). Previous studies have shown that ghrelin secretion rose in vivo in response to stimulation of sympathetic nerves (13,26) or by local infusion of adrenergic hormones into the stomach lining (14). Epinephrine i.v.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies in rats showed that plasma ghrelin levels are increased by stimulation of the sympathetic nervous system (13,14). To determine whether this response persists in vitro, we treated the PG-1 cells with two adrenergic agonists, norepinephrine and epinephrine.…”

Section: Stimulation Of Ghrelin Secretion In Pg-1 and Sg-1 Cells By βmentioning

confidence: 99%

“…The question arises as to the mechanism by which ghrelin secretion is regulated. Previous studies have shown that ghrelin secretion increases when sympathetic nerves are stimulated artificially (13) or when adrenergic hormones are infused locally into the stomach lining (14). The mechanism by which adrenergic stimulation enhances ghrelin secretion is not known.…”

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confidence: 99%

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Ghrelin secretion stimulated by β ₁ -adrenergic receptors in cultured ghrelinoma cells and in fasted mice

Zhao¹,

Sakata²,

Li³

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

180

219

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Ghrelin, an octanoylated peptide hormone produced in the stomach, rises dramatically in mouse plasma during chronic severe calorie deprivation, an event that is essential to maintain life. The mechanism for this increase is not understood. Here, we study the control of ghrelin secretion in tissue culture cells derived from mice bearing ghrelinomas induced by a tissue-specific SV40 T-antigen transgene. We found that the ghrelin-secreting cells express high levels of mRNA encoding β 1 -adrenergic receptors. Addition of norepinephrine or epinephrine to the culture medium stimulated ghrelin secretion, and this effect was blocked by atenolol, a selective β 1 -adrenergic antagonist. When WT mice were treated with reserpine to deplete adrenergic neurotransmitters from sympathetic neurons, the fasting-induced increase in plasma ghrelin was blocked. Inhibition was also seen following atenolol administration. We conclude that ghrelin secretion during fasting is induced by adrenergic agents released by sympathetic neurons and acting directly on β 1 receptors on the ghrelinsecreting cells of the stomach.

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Section: Discussionmentioning

confidence: 99%

Section: Stimulation Of Ghrelin Secretion In Pg-1 and Sg-1 Cells By βmentioning

confidence: 99%

mentioning

confidence: 99%

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Ghrelin secretion stimulated by β ₁ -adrenergic receptors in cultured ghrelinoma cells and in fasted mice

Zhao¹,

Sakata²,

Li³

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

180

219

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“…Not only does exposure of ghrelin cells to low glucose levels stimulate ghrelin release, but increased sympathoadrenal tone, as occurs during the usual counterregulatory response to hypoglycemia, could also stimulate ghrelin secretion (26,28). Supportive of this assertion, ghrelin secretion increases when sympathetic nerves are stimulated artificially or when adrenergic agents are infused locally into the gastric submucosa (29,30). Norepinephrine, epinephrine, and isoproterenol all stimulate ghrelin secretion from ghrelinoma cell lines and from primary cultures of gastric mucosal cells (26,(31)(32)(33)(34)(35)(36).…”

Section: Introductionmentioning

confidence: 99%

β1-Adrenergic receptor deficiency in ghrelin-expressing cells causes hypoglycemia in susceptible individuals

Mani¹,

Osborne-Lawrence²,

Vijayaraghavan³

et al. 2016

Journal of Clinical Investigation

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“…Considering the interaction between dopamine and ghrelin, the medical literature is far from offering a lucid explanation. This is because dopamine has been reported to increase ghrelin levels in the ghrelinoma cell line (18), while neither in vivo (19), nor in vitro (20) effects have been shown in gastric mucosal cells.…”

Section: Introductionmentioning

confidence: 95%

Prokinetics stimulate the increase of ghrelin in mice

Sagkan-Ozturk¹,

Demir²,

Öztürk³

2017

BLL

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OBJECTIVES: Intestinal motility is regulated by several neurotransmitters and neuropeptides including dopamine and acetylcholine as well as ghrelin. Metoclopramide and domperidone are long-standing treatment options for dysmotility, and erythromycin is suggested in selected patients. In the present study, we aimed to investigate the effects of mentioned prokinetics on ghrelin levels. METHODS: Serum ghrelin levels were estimated by using enzyme-linked immunoassay following a single administration of domperidone, metoclopramide, or erythromycin. RESULTS: Our results showed that both antidopaminergic and cholinergic prokinetics increase the circulating ghrelin levels. There was no signifi cant difference between enteral and parenteral control groups. Also, statistical analysis revealed that neither prokinetic was superior to the other in regard to its ghrelin stimulating effect. CONCLUSION: Conclusively, the present study demonstrated that the circulating levels of ghrelin increase by the administration of antidopaminergic and cholinergic prokinetics. Hence, this effect on ghrelin may partly be responsible for the motility-stimulating actions of domperidone, metoclopramide, and erythromycin (Fig. 2, Ref. 39). Text in PDF www.elis.sk.

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Secretion of ghrelin from rat stomach ghrelin cells in response to local microinfusion of candidate messenger compounds: A microdialysis study

Cited by 76 publications

References 71 publications

Ghrelin secretion stimulated by β ₁ -adrenergic receptors in cultured ghrelinoma cells and in fasted mice

Ghrelin secretion stimulated by β ₁ -adrenergic receptors in cultured ghrelinoma cells and in fasted mice

β1-Adrenergic receptor deficiency in ghrelin-expressing cells causes hypoglycemia in susceptible individuals

Prokinetics stimulate the increase of ghrelin in mice

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Secretion of ghrelin from rat stomach ghrelin cells in response to local microinfusion of candidate messenger compounds: A microdialysis study

Cited by 76 publications

References 71 publications

Ghrelin secretion stimulated by β 1 -adrenergic receptors in cultured ghrelinoma cells and in fasted mice

Ghrelin secretion stimulated by β 1 -adrenergic receptors in cultured ghrelinoma cells and in fasted mice

β1-Adrenergic receptor deficiency in ghrelin-expressing cells causes hypoglycemia in susceptible individuals

Prokinetics stimulate the increase of ghrelin in mice

Contact Info

Product

Resources

About

Ghrelin secretion stimulated by β ₁ -adrenergic receptors in cultured ghrelinoma cells and in fasted mice

Ghrelin secretion stimulated by β ₁ -adrenergic receptors in cultured ghrelinoma cells and in fasted mice