1983
DOI: 10.1016/s0174-3031(83)80013-4
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Secretion of acid proteinases by different species of the genus Candida

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Cited by 62 publications
(51 citation statements)
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“…In relation to C. tropicalis , although the majority of the isolates did not show proteolytic activity by semi‐quantitative method, it was verified that this species is capable of producing proteases in vitro in solid medium containing BSA as the only source of nitrogen. Reports found in the literature suggest that the production of proteases in this species is lower than that observed for C. albicans 13,36–38 …”
Section: Discussionmentioning
confidence: 58%
“…In relation to C. tropicalis , although the majority of the isolates did not show proteolytic activity by semi‐quantitative method, it was verified that this species is capable of producing proteases in vitro in solid medium containing BSA as the only source of nitrogen. Reports found in the literature suggest that the production of proteases in this species is lower than that observed for C. albicans 13,36–38 …”
Section: Discussionmentioning
confidence: 58%
“…albicans strains with higher proteolytic activity were shown to be more virulent [125][126][127][128][129] and protease-deficient mutants of C. albicans were less pathogenic [130,131]. Interestingly, C. albicans isolates from HIV-positive individuals presented higher aspartic protease activity and were more adherent than the isolates from HIV-negative individuals [105,128,129,132].…”
Section: Saps: Virulence Attributes With Multiple Biological Functionsmentioning
confidence: 99%
“…Extracellular proteinase activity has been demonstrated, by auxanographic methods, for most isolates of C. albicans, C. tropicalis and C. parapsilosis while various isolates of C. glabrata, C. guilliermondii, C. pseudotropicalis and C. krusei were negative [43]. A secretory acid proteinase antigen and specific antibodies has been demonstrated in patients infected with C. albicans [44,45].…”
Section: Proteinasementioning
confidence: 99%
“…At least seven genes encode for a family of secretory acid proteinases in C. albicans and the expression of six of these (SPA1-6) is regulated differentially while one gene (SPA7) is not expressed under any conditions so far examined [48]. Different species of Candida appear to secrete antigenically distinct acid proteinases and some species do not appear to secrete proteinases [43,49]. Rabbits infected with C. tropicalis, C. parapsilosis and C. krusei did not yield positive results with antibody raised against C. albicans proteinase [47].…”
Section: Proteinasementioning
confidence: 99%