Secretin and autism: a basic morphological study about the distribution of secretin in the nervous system

Köves, Katalin; Kausz, Mária; Reser, Diana; Illyés, G.; Takács, J.; Heinzlmann, Andrea; Gyenge, Eszter; Horváth, Károly

doi:10.1016/j.regpep.2004.04.026

Cited by 30 publications

(22 citation statements)

References 28 publications

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“…After nuclear staining with hematoxylin, slides were mounted with either the Ultramount aqueous permanent mounting medium (Dako) or the GLC mounting medium (Sakura, Zoeterwoude, The Netherlands). Immunohistochemical reactions for secretin and vasoactive intestinal polypeptide (VIP) were prepared using the indirect immunofluorescence technique as described earlier [15,16]. Antibody for claudin 4 was applied for the detection of tight junction components that are specific for pancreatic ductal or biliary origin.…”

Section: Methodsmentioning

confidence: 99%

Cushing’s Syndrome in a Child with Pancreatic Acinar Cell Carcinoma

et al. 2007

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A case of pancreatic acinar cell tumor (ACC) is presented in a 10-year-old boy. The tumor manifested clinically with Cushing's syndrome, high serum adrenocorticotropic hormone (ACTH) and cortisol concentrations. In addition, excessive serum levels of alpha-fetoprotein (AFP) were detected. Surgical resection was not possible due to retroperitoneal invasion. Biopsy of the mass showed a solid, poorly differentiated ACC of the pancreas. Periodic acid Schiff positive cytoplasmic granules, trypsinogen, keratins, alpha-1-antitrypsin, and AFP were identified in the tumor cells. Electron microscopy demonstrated zymogen granules as well as isolated dense core granules. Using immunochemiluminometric assay, a high quantity of ACTH was found in the fresh frozen tumor extract. ACTH, chromogranin A, and corticotropin-releasing factor were identified only in a few cells by immunohistochemistry. Combined radiochemotherapy was temporarily effective in reducing the tumor mass and serum AFP. Serum ACTH and cortisol levels dropped progressively and definitively to normal values after chemotherapy, and the Cushing's syndrome subsided. Two years later, the patient died with metastatic disease. The presented case of ACC is interesting due to high serum AFP values and ectopic ACTH secretion resulting in Cushing's syndrome.

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Section: Methodsmentioning

confidence: 99%

Cushing’s Syndrome in a Child with Pancreatic Acinar Cell Carcinoma

et al. 2007

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“…In 1998, a study (Horvath et al, 1998) reported behavioral improvements in three preschool children after intravenous administration of secretin, a gastrointestinal polypeptide produced in the duodenum and secreted in response to increased acidity. Animal studies suggest a role for secretin in autism, showing its distribution in the developing central nervous system of mouse embryos (Siu, Sham, & Chow, 2005) as well as immunoreactivity in several brain areas in rats including the cerebellum, amygdala, motor and sensory cortices (Koves et al, 2004;Welch et al, 2003). Following publication of this study, secretin administration as a treatment option for autism was popularized after widespread media attention on television shows such as Dateline and Good Morning America.…”

Section: Alternative Theoriesmentioning

confidence: 99%

A Review on the Cognitive Neuroscience of Autism

Koyama

2009

Act Nerv Super

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With increased recognition in the media, heightened prevalence, and advances in research technologies, investigation into the causes of autism has broadened in recent years. Studies at the molecular, structural, and behavioral levels have resulted in significant findings, linking autism to qualitative differences in neurological function and an alteration of early development. Familial aggregation of autism demonstrates a strong genetic factor, although genetics can not completely account for its pathogenesis. Studies show autism having one of the most complex pathologies among neurodevelopmental disorders. Future studies applying sophisticated methodologies in new areas may shed light on current mysteries surrounding the disorder.

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“…Several studies have investigated the location of action of secretin in the central nervous system (CNS). Several studies in rats [Welch et al, 2003;Koves et al, 2004;Kuntz et al, 2004] have described activation and immunoreactivity of multiple areas of the brain with intraventricular secretin injection. Areas of activation included Purkinje cells, central cerebellar nuclei, hippocampus, and amygdala.…”

Section: Secretinmentioning

confidence: 99%

Novel treatments for autistic spectrum disorders

Levy

Hyman

2005

Ment. Retard. Dev. Disabil. Res. Rev.

144

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In no area of developmental pediatric practice is there more controversy regarding the choice of treatment than related to children with autistic spectrum disorders (ASD). Complementary and alternative medical therapies (CAM) are often elected because they are perceived as treating the cause of symptoms rather than the symptoms themselves. CAM used for autism can be divided by proposed mechanism: immune modulation, gastrointestinal, supplements that affect neurotransmitter function, and nonbiologic intervention. Secretin as a therapy for autism is discussed as an example of how a clinical observation rapidly grew to a widespread treatment before well-designed studies demonstrated absence of effect. The plausibility for behavioral effect was not substantiated by clinical studies. CAM used for treatment of autism is examined in terms of rationale, evidence of efficacy, side effects, and additional commentary. Families and clinicians need access to well-designed clinical evidence to assist them in choice of therapies.

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Secretin and autism: a basic morphological study about the distribution of secretin in the nervous system

Cited by 30 publications

References 28 publications

Cushing’s Syndrome in a Child with Pancreatic Acinar Cell Carcinoma

Cushing’s Syndrome in a Child with Pancreatic Acinar Cell Carcinoma

A Review on the Cognitive Neuroscience of Autism

Novel treatments for autistic spectrum disorders

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