Secreted phosphoprotein 24 kD (Spp24) inhibits growth of human pancreatic cancer cells caused by BMP-2

Li, Chenshuang; Tian, Haijun; Zou, Min; Zhao, Ke‐Wei; Li, Yawei; Lao, Li; Brochmann, Elsa J.; Duarte, Maria Eugênia Leite; Daubs, Michael D.; Zhou, Yan-Heng; Murray, Samuel S.; Wang, Jeffrey C.

doi:10.1016/j.bbrc.2015.08.124

Cited by 22 publications

(16 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Spp24 may bind with BMP2 and, consequently, inhibit the function of BMP2. In addition, some studies have shown that spp24 could induce cancer cell apoptosis in vitro and in vivo (22). In our study, we also found that spp24 dramatically induced apoptosis of tumor cells; however, BMP2 did not affect cell apoptosis.…”

Section: Discussionsupporting

confidence: 74%

“…Spp24 can bind with BMP2 and inhibit its osteogenic activity (28,29). Several studies have indicated that spp24 could inhibit cancer cell proliferation and tumor growth (22,23). Lee et al showed that spp24 could ameliorate the effects of BMP2 on lung cancer in a subcutaneous and intratibial tumor model (23).…”

Section: Discussionmentioning

confidence: 99%

“…Lee et al showed that spp24 could ameliorate the effects of BMP2 on lung cancer in a subcutaneous and intratibial tumor model (23). Recently, Li et al indicated that spp24 could block the stimulatory effects of BMP2 on pancreatic cancer in vitro and in a xenograft tumor model (22). However, it is not clear whether spp24 could influence the effects of BMP2 on prostate cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Spp24 exists in the bone environment in several forms and can inhibit the BMP-induced bone formation. Several studies have shown that spp24 could suppress pancreatic cancer growth (22) and lung cancer (23) caused by BMP2. Previous studies have shown that BMP2 could promote proliferation and migration of PC3 cells (19,24).…”

mentioning

confidence: 99%

See 3 more Smart Citations

Secreted Phosphoprotein 24 kD Inhibits Growth of Human Prostate Cancer Cells Stimulated by BMP-2

Lao

Shen

Tian

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Secreted Phosphoprotein 24 kD Inhibits Growth of Human Prostate Cancer Cells Stimulated by BMP-2

Lao

Shen

Tian

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…Coleusin factor, an inhibitor targeting BMP-2, exerted its anticancer effects on osteosarcoma by inducing osteoblast differentiation [135]. Moreover, phosphoprotein Spp24 secreted by BMP binding protein diminished BMP-2-initated tumor growth and thus resulted in significant apoptosis of cancer cells, which would be developed into a new therapeutic agent for clinical applications [136]. …”

Section: Therapeutic Approaches Against Bmp Signaling In Cancermentioning

confidence: 99%

BMP signaling and its paradoxical effects in tumorigenesis and dissemination

Zhang

Long

et al. 2016

Oncotarget

View full text Add to dashboard Cite

Bone morphogenetic proteins (BMPs) play important roles in embryonic and postnatal development by regulating cell differentiation, proliferation, motility, and survival, thus maintaining homeostasis during organ and tissue development. BMPs can lead to tumorigenesis and regulate cancer progression in different stages. Therefore, we summarized studies on BMP expression, the clinical significance of BMP dysfunction in various cancer types, and the molecular regulation of various BMP-related signaling pathways. We emphasized on the paradoxical effects of BMPs on various aspects of carcinogenesis, including epithelial–mesenchymal transition (EMT), cancer stem cells (CSCs), and angiogenesis. We also reviewed the molecular mechanisms by which BMPs regulate tumor generation and progression as well as potential therapeutic targets against BMPs that might be valuable in preventing tumor growth and invasion.

show abstract

Bone morphogenetic protein‐2 promotes osteosarcoma growth by promoting epithelial‐mesenchymal transition (EMT) through the Wnt/β‐catenin signaling pathway

Tian

Zhou

Chen

et al. 2019

Journal Orthopaedic Research

Self Cite

View full text Add to dashboard Cite

The correlation between BMP-2 and osteosarcoma growth has gained increased interest in the recent years, however, there is still no consensus. In this study, we tested the effects of BMP-2 on osteosarcoma cells through both in vitro and in vivo experiments. The effect of BMP-2 on the proliferation, migration and invasion of osteosarcoma cells was tested in vitro. Subcutaneous and intratibial tumor models were used for the in vivo experiments in nude mice. The effects of BMP-2 on EMT of osteosarcoma cells and the Wnt/b-catenin signaling pathway were also tested using a variety of biochemical methods. In vitro tests did not show a significant effect of BMP-2 on tumor cell proliferation. However, BMP-2 increased the mobility of tumor cells and the invasion assay demonstrated that BMP-2 promoted invasion of osteosarcoma cells in vitro. In vivo animal study showed that BMP-2 dramatically enhanced tumor growth. We also found that BMP-2 induced EMT of osteosarcoma cells. The expression levels of Axin2 and Dkk-1 were both down regulated by BMP-2 treatment, while b-catenin, c-myc and Cyclin-D1 were all upregulated. The expression of Wnt3a and p-GSK-3b were also significantly upregulated indicating that the Wnt/b-catenin signaling pathway was activated during the EMT of osteosarcoma driven by BMP-2. From this study, we can conclude that BMP-2 significantly promotes growth of osteosarcoma cells (143B, MG63), and enhances mobility and invasiveness of tumor cells as demonstrated in vitro. The underlying mechanism might be that BMP-2 promotes EMT of osteosarcoma through the Wnt/b-catenin signaling pathway. ß

show abstract

Secreted phosphoprotein 24 kD (Spp24) inhibits growth of human pancreatic cancer cells caused by BMP-2

Cited by 22 publications

References 28 publications

Secreted Phosphoprotein 24 kD Inhibits Growth of Human Prostate Cancer Cells Stimulated by BMP-2

Secreted Phosphoprotein 24 kD Inhibits Growth of Human Prostate Cancer Cells Stimulated by BMP-2

BMP signaling and its paradoxical effects in tumorigenesis and dissemination

Bone morphogenetic protein‐2 promotes osteosarcoma growth by promoting epithelial‐mesenchymal transition (EMT) through the Wnt/β‐catenin signaling pathway

Contact Info

Product

Resources

About