Secreted phosphoprotein 24 kD inhibits nerve root inflammation induced by bone morphogenetic protein-2

Tian, Haijun; Li, Chenshuang; Scott, Trevor P.; Montgomery, Scott R.; Phan, Kevin; Lao, Li; Zhang, Wei; Li, Yawei; Hayashi, Tetsuo; Takahashi, Shinji; Alobaidaan, Raed; Ruangchainikom, Monchai; Zhao, Ke‐Wei; Brochmann, Elsa J.; Murray, Samuel S.; Wang, Jeffrey C.; Daubs, Michael D.

doi:10.1016/j.spinee.2014.09.021

Cited by 8 publications

(5 citation statements)

References 25 publications

(30 reference statements)

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“…It is hypothesized that one function of Spp24 may relate to controlling the availability of free BMPs and TGF-b in the physiologically active bone environment [10]. Spp24 has also been employed to inhibit BMP activity in situations such as the nerve root inflammation that can occur as a side effect of BMP use in spine fusion surgery [11].…”

Section: Introductionmentioning

confidence: 99%

Secreted phosphoprotein 24 kD (Spp24) inhibits growth of human pancreatic cancer cells caused by BMP-2

Tian

Zou

et al. 2015

Biochemical and Biophysical Research Communications

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Section: Introductionmentioning

confidence: 99%

Secreted phosphoprotein 24 kD (Spp24) inhibits growth of human pancreatic cancer cells caused by BMP-2

Tian

Zou

et al. 2015

Biochemical and Biophysical Research Communications

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“…Among the identified proteins, AMBP has the functions of immunomodulation, inhibition of inflammatory mediators, antioxidation, and inhibition of smooth muscle contraction ( 19 , 20 ). SPP2 has the effects of regulation of vascular calcification and anti-inflammation ( 21 , 22 , 23 ). GC can isolate actin, regulate immune and inflammatory responses, bind fatty acids, and control bone development ( 24 , 25 , 26 ).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the correlation between fetuin-B levels and essential hypertension: a cross-sectional study

Gao,

Liu,

et al. 2023

Endocrine Connections

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Background: Fetuin-B, a cytokine that regulates lipid metabolism, has recently been linked to cardiovascular diseases (CVDs) such as coronary heart disease. In this study, we discussed the relationship between fetuin-B and essential hypertension. Method: A bioinformatics analysis of fetuin-B was performed. A total of 206 with essential hypertension (EH) and 180 age-and-sex-matched healthy subjects (NT) were enrolled. Plasma fetuin-B, endothelin-1 (ET-1), nitric oxide (NO) and adiponectin (ADI) levels were measured using ELISA kits. Results: Bioinformatics analysis has revealed that fetuin-B plays an important role in pathways such as lipid metabolism. Compared with healthy subjects, serum fetuin-B levels in patients with essential hypertension were significantly increased. Correlation analysis showed that the serum fetuin-B level was positively correlated with SBP, DBP, BMI, FAT, WHR, IMT, LDL-C, GGT, ALT, albumin, FBG, glycated hemoglobin, and ET-1 in the overall study subjects (all P < 0.05) and negatively correlated with HDL-C, ADI, and NO (All P < 0.05). Multivariate linear regression analysis showed that SBP, FBG, LDL-C, ADI, and ET-1 were independent factors affecting serum fetuin-B. A binary logistic regression analysis showed that fetuin-B was an independent risk factor for primary hypertension (OR: 1.060, 95%CI: 1.034–1.086, P < 0.001). ROC curve analysis was used to evaluate the predictive value of fetuin-B for primary hypertension, and the optimal cutoff point was 83.14 μg/mL (sensitivity 77.4%, specificity 63.3%) (AUC) = 0.7738, 95% CI 0.7276–0.8200, P < 0.001). Conclusion: Elevated fetuin-B levels are associated with an increased risk of essential hypertension.

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“…In the DRG, inflammatory mediators including pro-inflammatory cytokines released from resident cells as wells as blood-derived immune cells can act locally to sensitize nociceptors. BMP-2 itself, although most prominently known for pro-morphogenic roles, can exert numerous pro-inflammatory effects [17, 20, 21, 38]. Administration of rhBMP-2 increases levels of circulating pro-inflammatory and osteoclastic cytokines in a rodent model of PLF [39].…”

Section: Discussionmentioning

confidence: 99%

Bone morphogenetic protein-2-mediated pain and inflammation in a rat model of posterolateral arthrodesis

et al. 2016

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BackgroundBone morphogenetic protein-2 (BMP-2) is a pleiotropic, secreted molecule with diverse effects. The potent ability of BMP-2 to stimulate bone growth prompted its widespread clinical use for arthrodesis (spine fusion). However, elevated post-operative pain in patients treated with BMP-2 has been increasingly reported. Determining whether BMP-2 induces pain directly or whether it induces neuroinflammation, which could lower the threshold for pain, is important for developing therapeutic interventions. We therefore modeled the clinical use of BMP-2 for posterior lumbar fusion by implanting absorbable collagen sponges soaked with either recombinant human BMP-2 (rhBMP-2) or vehicle above the L4–L5 transverse processes of rat spine.ResultsUsing microarray analysis we found that implantation of rhBMP-2-soaked absorbable collagen sponges resulted in altered expression of numerous pro-inflammatory genes in the adjacent dorsal root ganglia (DRG) showing that implantation of rhBMP-2/absorbable collagen sponges triggers potent neuroinflammatory responses in the DRG-2. Interestingly, direct BMP-2 treatment of DRG explants resulted in changes in gene expression that were not specifically pro-inflammatory. Rats implanted with rhBMP-2 in absorbable collagen sponges also exhibited a transient change in thermal and mechanical sensitivity indicating that rhBMP-2 applied to the lumbar spine could increase pain sensitivity. Immunohistochemical analysis indicated macrophage infiltration in the DRG and spinal nerve in rats implanted with rhBMP-2/absorbable collagen sponges or absorbable collagen sponges alone, but not in rats that underwent surgery without implantation of the absorbable collagen sponges suggesting that the sponges contributed to the biological response. Indeed, analysis of DRGs taken from rats implanted with absorbable collagen sponges without rhBMP-2 showed a significant change in gene expression distinct from DRGs from rats undergoing surgery only.ConclusionsOur data indicate that implantation of rhBMP-2/absorbable collagen sponges on the lumbar spine triggers potent neuroinflammatory responses in the DRG. Importantly, however, these BMP-2 effects may be partially mediated through a response to the absorbable collagen sponges.

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Secreted phosphoprotein 24 kD inhibits nerve root inflammation induced by bone morphogenetic protein-2

Cited by 8 publications

References 25 publications

Secreted phosphoprotein 24 kD (Spp24) inhibits growth of human pancreatic cancer cells caused by BMP-2

Secreted phosphoprotein 24 kD (Spp24) inhibits growth of human pancreatic cancer cells caused by BMP-2

Evaluation of the correlation between fetuin-B levels and essential hypertension: a cross-sectional study

Bone morphogenetic protein-2-mediated pain and inflammation in a rat model of posterolateral arthrodesis

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