Secondary syphilis mimicking pemphigus vulgaris

Abstract

References1 Rasktar G, Okagaki T, Twiggs LB, Clark BA. Early invasive and in situ warty carcinoma of the vulva. clinical, histologic, and electron microscopic study with particular reference to viral association. Am J Obstet Gynecol 1982; 143: 814-820. 2 Aroni K, Lazaris AC, Ioakim-Liossi A, Paraskevakou H, Davaris PS. Histological diagnosis of cutaneous 'warty' carcinoma on a pre-existing HPV lesion. Acta Derm Venereol 2000; 80: 294-296. 3 Cho NH, Joo HJ, Ahn HJ, Jung WH, Lee KG. Detection of human papillomavirus in warty carcinoma of the uterine cervix: comparison of immunohistochemistry, in situ hybridization and in situ polymerase chain reaction methods. Pathol Res Pract 1998; 194: 713-720. 4 Ho CM, Chien TY, Huang SH, Lee BH, Chang SF. Integrated human papillomavirus type 52 and 58 are infrequently found in cervical cancer, and high viral loads predict risk of cervical cancer. Gynecol Oncol 2006; 102: 54-60. 5 Hampl M, Ramp U, Bender HG, Kueppers V. A case of a pT3, HPV 52-positive vulvar carcinoma in an 18-year-old woman. Gynecol Oncol 2006; 101: 530-533. 6 Fölster-Holst R, Swensson O, Stockfleth E, Mönig H, Mrowietz U, Christophers E. Comèl-Netherton syndrome complicated by papillomatous skin lesions containing human papillomaviruses 51 and 52 and plane warts containing human papillomavirus 16. Br

Oral Syphilis: a retrospective analysis of 12 cases and a review of the literature

“…In contrast to published data, mucosal patches are detected in only the 16% of patients and any evidence of leukoplakia‐like lesions. Interestingly, case 2 affected by syphilis in secondary stage mimicking a blistering mucositis is never described in the current literature up to the paper by Mignogna et al (). Another interesting data are the necrosis of the dorsum of the tongue in patient 11 with tertiary disease.…”

The Immunopathobiology of Syphilis: The Manifestations and Course of Syphilis Are Determined by the Level of Delayed-Type Hypersensitivity

“…Hair loss can also occur (moth-eaten alopecia/alopecia syphilitica), typically affecting the scalp, but also the eyebrows or total body hair loss. Secondary syphilis has been termed the “great masquerader”, because its skin lesions show such diverse clinical and/or histologic morphologies, mimicking alopecia areata (130), bullous pemphigoid (131), cutaneous lymphoid hyperplasia (pseudolymphoma) (132–135), erythema multiforme (126, 136), granuloma annulare (43, 128, 137, 138), histiocytoma (34), leprosy (128, 139, 140), lichen planus (34, 126, 135, 141, 142), lupus erythematosus (43, 128, 143), mycosis fungoides (126, 144–146), pemphigus vulgaris (147), pityriasis lichenoides et varioliformis acuta (PLEVA) (34, 126, 135), pruritic (eczematous) dermatoses (126, 128, 148), psoriasis (34, 128, 149, 150), pustular psoriasis (34, 128), sarcoidosis (34, 135, 151–155), small vessel vasculitis (156), suppurative folliculitis (157), superficial thrombophlebitis (158), Sweet’s syndrome (128, 159), tinea imbricata and erythema annulare centrifugum (34, 160), and urticaria (104). Ulcerative nodular presentations are rare and can occur secondary to follicular pustules (157, 161), or an obliterative endarteritis, known as lues maligna (162, 163).…”

Secondary Syphilis Presenting as Glossodynia, Plaques en Prairie Fauchée, and a Split Papule at the Oral Commissure: Case Report and Review

“…Differently, Hamlyn et al [9] reported a case series of three patients in whom secondary syphilis presented solely as a tonsillitis. A comprehensive review of the literature shows that oral lesions have been described as solitary or multiple ulcerations [7, 14, 18, 23, 32, 33], as erosions [10, 14], as a bullous-erosive lesion resembling pemphigus vulgaris [34], as macular, papular, and nodular lesions [3, 14, 18], as condylomata lata [6], as leukoplakia-like [35, 36], as oral hairy leukoplakia-like [8, 18] lesions, and as painless nodules on the tongue [37]. …”