Secondary primary cancer in patients with head and neck carcinoma: the differences among hypopharyngeal, laryngeal, and other sites of head and neck cancer

Abstract

This paper presents a population-based retrospective cohort study to identify the differences in secondary primary cancer (SPC) among hypopharyngeal, laryngeal, and other sites of head and neck cancer (HNC). Data were collected from the Taiwan National Health Insurance Research Database (NHIRD) for the period 1979-2010. The study cohort comprised 5914 newly diagnosed hypopharyngeal and laryngeal patients from the registry of the Catastrophic Illness Patients Database (CIPD). The comparison cohort comprised 5914 patients with other sites of HNC. We used a multivariate Cox proportional-hazards regression model to assess the risk of developing SPC. The incidence of SPC in the study cohort was 68% higher compared with the comparison cohort (23.9 vs. 14.2 per 1000 person-years, Incident Rate Ratio = 1.68). The study cohort had a higher adjusted hazard ratio (HR) in oesophageal cancer (HR = 3.47) and lung cancer (HR = 1.89). The difference in SPC incidence between the study and comparison cohort was significant.

Early detection of esophageal second primary tumors using Lugol chromoendoscopy in patients with head and neck cancer: A systematic review and meta‐analysis

“…The hypopharynx, and in particular involvement of the piriform sinus, is a well‐known risk factor for the development of esophageal‐SPTs . The results from the present review also SPTs underlined this.…”

“…31 The hypopharynx, and in particular involvement of the piriform sinus, is a well-known risk factor for the development of esophageal-SPTs. [57][58][59][60] The results from the present review also SPTs underlined this. Wang WL et al compared two hypopharyngeal HNSCC cohorts: before and after implementing pretreatment Lugol chromoendoscopy esophagus screening.…”

The Preliminary Study of 16α-[18F]fluoroestradiol PET/CT in Assisting the Individualized Treatment Decisions of Breast Cancer Patients

“…With the development of modern cancer care, the incidence of secondary primary tumor increased during the past decades [ 21 ]. In our study, two patients had secondary primary cancers, they referred to undergo 18 F-FES PET/CT in order to predict origin of metastasis; and the results showed that 18 F-FES PET/CT may be useful.…”

Multiple primary malignant neoplasms of the glottis, renal pelvis, urinary bladder, oral floor, prostate, and esophagus in a Japanese male patient: a case report

“…Of 551 patients, they reported that the incidence of double cancer was 26.9%, triple cancer was 6.2%, quadruple cancer was 1.1%, and quintuple cancer was 0.2% [ 12 ]. Liu et al studied the types of second primary malignancies among the patients with head and neck cancer [ 13 ]. The types of second primary malignancy with adjusted hazard ratio (95% confidence interval) were esophageal cancer 3.47 (2.40 to 5.03), prostate cancer 0.94 (0.45 to 1.95), bladder cancer 0.90 (0.39 to 2.10), among others [ 13 ].…”

“…Liu et al studied the types of second primary malignancies among the patients with head and neck cancer [ 13 ]. The types of second primary malignancy with adjusted hazard ratio (95% confidence interval) were esophageal cancer 3.47 (2.40 to 5.03), prostate cancer 0.94 (0.45 to 1.95), bladder cancer 0.90 (0.39 to 2.10), among others [ 13 ]. Powell et al considered the prognosis of patients with MPMN [ 14 ] by dividing patients with MPMN into synchronous and metachronous cases according to the classification proposed by Moertel [ 3 ].…”