Multiple primary malignant neoplasms of the glottis, renal pelvis, urinary bladder, oral floor, prostate, and esophagus in a Japanese male patient: a case report

Mukaiyama, Yoshihiro; Suzuki, Motofumi; Morikawa, Teppei; Mori, Yuichi; Takeshima, Yuta; Fujimura, Tetsuya; Fukuhara, Hiroshi; Nakagawa, Tohru; Nishimatsu, Hiroaki; Kume, Haruki; Homma, Yukio

doi:10.1186/1477-7819-12-294

Cited by 12 publications

(12 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The case presented here is exceedingly rare in view of the number of primary malignancies and their combination. We found only 13 papers that reported multiple malignancies of five or six different organs from a search of PubMed and the Japan Medical Abstracts Society databases (Table II) (4)(5)(6)(7)(8)(9)(10). Besides, we could not find any reports of this particular combination of MPMs to date.…”

Section: Discussionmentioning

confidence: 97%

Multiple primary malignancies of six organs in a Japanese male patient: A case report

et al. 2019

View full text Add to dashboard Cite

As a result of recent advances in diagnostic techniques and treatment modalities, the number of patients diagnosed with multiple primary malignancies has been increasing. We report the case of a 79-year-old male with multiple primary malignancies of three histological types in six different organs: Stomach, prostate, colon, urinary bladder, facial skin and pancreas, in chronological order. The first malignancy was upper gastric cancer diagnosed in 1998. The second and third malignancies were prostate cancer and ascending colon cancer, which were diagnosed in 2010. The fourth malignancy was bladder cancer diagnosed in 2011. The fifth and sixth malignancies were squamous cell skin cancer of the right cheek and intraductal papillary mucinous carcinoma (IPMC), respectively, diagnosed in 2014. The gastric cancer, colon cancer, bladder cancer, skin cancer and IPMC were surgically resected. The prostate cancer was treated by anti-androgen therapy. The patient died of local recurrence of IPMC in August 2016. Although multiple primary malignancies are not uncommon, diagnosis of six primary malignancies in a single patient, as reported in the present study, is extremely rare. It is important to understand the characteristics of multiple primary malignancies in order to administer suitable treatment and determine relevant follow-up plans for patients with cancer.

show abstract

Section: Discussionmentioning

confidence: 97%

Multiple primary malignancies of six organs in a Japanese male patient: A case report

et al. 2019

View full text Add to dashboard Cite

show abstract

“…[13][14][15] Occurrence of multiple primary malignancies can be due to various genetic events or common environmental risk factors such as smoking, alcoholism, family history of cancer or immunological defects and prior irradiation or chemotherapy. 16 Various familial cancer syndromes are linked to SPM including lynch I and II syndromes, Li-Fraumeni syndrome, Fanconi anaemia, xeroderma pigmentosum and Von Hippel-Lindau. 17 RCC is the most common cancer arising from the kidney with commonest metastatic sites being the lungs, bones, liver and brain whereas gastric metastases from RCC are exceedingly rare.…”

Section: Discussionmentioning

confidence: 99%

Synchronous malignancy of stomach and kidney: an unusual combination: a case report

et al. 2020

View full text Add to dashboard Cite

Synchronous occurrence of primary gastric cancer with primary renal cell carcinoma (RCC) is exceedingly rare. We report a case of a 70 years old gentleman who presented with a history of epigastric fullness and tarry stools from 1 month, along with significant weight loss which he was unable to quantify. Esophagogastroduodenoscopy showed ulceroproliferative growth in the antropyloric region of stomach causing complete outlet obstruction. Histopathology revealed poorly differentiated mucinous adenocarcinoma. Contrast enhanced computed tomography (CECT) abdomen showed an asymmetrical circumferential growth in the antropyloric region leading to obstruction. A heterogeneously enhancing hypervascular mass was also visualized over the lower pole of left kidney with an initial impression of metastasis. A concomitant radical subtotal gastrectomy and radical left nephrectomy was performed. Pathological examination confirmed gastric adenocarcinoma (T4a) and renal cell carcinoma-RCC (T3a). Most of the operable synchronously occurring second primary malignancy (SPM) can be resected in a single stage.

show abstract

“…Conversely, as PRC is asymptomatic in the early stages ( 47 ) and is an internal disease, it is frequently incidentally detected. In order to confirm the diagnosis method of PRC of those patients, the cases in Table I were further reviewed and the manner in which the subsequent PRC was detected is indicated ( 28 , 29 , 31 , 33 – 35 , 37 , 38 ) ( Table II ). Of the 9 patients in which PRC was diagnosed, including the present case, PRC was detected by a serum test in 2, incidentally by surgery of the other tumor in 2, by FDG-PET in 2 and by clinical symptoms in 1 (PRC detection in 2 patients was not described).…”

Section: Discussionmentioning

confidence: 99%

Triple primary cancer of the head and neck, skin and prostate: A case report and literature review

et al. 2018

View full text Add to dashboard Cite

Second primary cancer (SPC) is an important prognostic factor for patients with head and neck cancer (HNC); therefore, the association between the prognosis and development of SPC has been well-reported. The use of 2-[18F]-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET) is valuable to examine cancer stage, evaluate treatment responses and investigate suspected relapses or metastases. In the present study, the case of a male patient who was diagnosed with three primary cancer types, including well to moderately differentiated squamous cell carcinoma (SCC) of the mandible, axillary cutaneous poorly differentiated SCC and prostate adenocarcinoma, was described. Among these, mandible cancer was the first diagnosed when the patient was 70 years of age. Synchronous skin and prostate cancer (PRC) types then developed 3 years later. To the best of our knowledge, this is the first report of the aforementioned combination of cancer types. Postoperative FDG-PET was not performed as no lesions of recurrence or metastases of mandible cancer were found. Three years later, the PRC was asymptomatic and was incidentally detected by FDG-PET performed for a preoperative evaluation of skin cancer. It was indicated that FDG-PET could be utilized in patients with HNC due to there being no accurate FDG-PET protocol to detect SPC over a long-term follow-up.

show abstract

Multiple primary malignant neoplasms of the glottis, renal pelvis, urinary bladder, oral floor, prostate, and esophagus in a Japanese male patient: a case report

Cited by 12 publications

References 24 publications

Multiple primary malignancies of six organs in a Japanese male patient: A case report

Multiple primary malignancies of six organs in a Japanese male patient: A case report

Synchronous malignancy of stomach and kidney: an unusual combination: a case report

Triple primary cancer of the head and neck, skin and prostate: A case report and literature review

Contact Info

Product

Resources

About