Abstract:Second primary cancer (SPC) is an important prognostic factor for patients with head and neck cancer (HNC); therefore, the association between the prognosis and development of SPC has been well-reported. The use of 2-[18F]-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET) is valuable to examine cancer stage, evaluate treatment responses and investigate suspected relapses or metastases. In the present study, the case of a male patient who was diagnosed with three primary cancer types, including we… Show more
“…The emergence of second primary tumours can be explained by the field cancerization phenomenon and corresponds to an important prognostic factor in head and neck cancers (Bagan et al, 2020; Maruyama et al, 2018). In our review, we found 84 cases of new primary tumours (40% of the P‐OSCC sample), 10 of which were described as third primary tumours, 1 as a fourth primary tumour and 1 as a fifth primary tumour.…”
Proliferative verrucous leukoplakia (PVL) is a potentially malignant oral disorder first described by Hansen et al. (1985). It is characterized as a distinct aggressive form of oral leukoplakia, due to its progressive and multifocal behaviour, characterized by relapses, spreading and high rates of malignant transformation (Bombeccari Giannì et al., 2018;Hansen et al., 1985). Its aetiology is not related to known risk factors for conventional oral leukoplakia or oral squamous cell carcinomas (OSCCs), such as tobacco and alcohol; however, some genetic factors have been observed in PVL but without a definition of pathogenesis and aetiology (El-Naggar et al., 2017;Okoturo et al., 2018).PVL has distinct clinical stages, such as the appearance of one or more white plaques or spots on the oral mucosa; the increase and spread of these lesions to cover other sites; a verrucous surface appearance to some or all the leukoplakia and, finally, malignant transformation into verrucous carcinoma or OSCC (Gillenwater et al.,
“…The emergence of second primary tumours can be explained by the field cancerization phenomenon and corresponds to an important prognostic factor in head and neck cancers (Bagan et al, 2020; Maruyama et al, 2018). In our review, we found 84 cases of new primary tumours (40% of the P‐OSCC sample), 10 of which were described as third primary tumours, 1 as a fourth primary tumour and 1 as a fifth primary tumour.…”
Proliferative verrucous leukoplakia (PVL) is a potentially malignant oral disorder first described by Hansen et al. (1985). It is characterized as a distinct aggressive form of oral leukoplakia, due to its progressive and multifocal behaviour, characterized by relapses, spreading and high rates of malignant transformation (Bombeccari Giannì et al., 2018;Hansen et al., 1985). Its aetiology is not related to known risk factors for conventional oral leukoplakia or oral squamous cell carcinomas (OSCCs), such as tobacco and alcohol; however, some genetic factors have been observed in PVL but without a definition of pathogenesis and aetiology (El-Naggar et al., 2017;Okoturo et al., 2018).PVL has distinct clinical stages, such as the appearance of one or more white plaques or spots on the oral mucosa; the increase and spread of these lesions to cover other sites; a verrucous surface appearance to some or all the leukoplakia and, finally, malignant transformation into verrucous carcinoma or OSCC (Gillenwater et al.,
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