Secondary Prevention of Arterial Disease in Very Elderly People: Results From a Prospective Registry (FRENA)

Abstract

There is little information on the effectiveness of secondary prevention interventions in very elderly patients. In this article, the incidence of major cardiovascular events during a 12-month follow-up period in a series of consecutive patients with coronary, cerebrovascular, or peripheral artery disease is analyzed. As of October 2006, 1264 patients had been enrolled. Of these, 324 (26%) were >or=75 years of age. Their incidence rate of 22 events per 100 patient-years (95% CI, 17-28) was over 2-fold the 7.9 (95% CI, 6.2-10) found in those <75 years of age. Among them, only chronic heart failure and diabetes were independently associated with an increased risk for major events, whereas the use of angiotensin II antagonists was associated with a lower risk. Patients >or=75 years of age had an over 2-fold higher incidence of major cardiovascular events. The use of angiotensin II antagonists was associated with a lower risk.

Cardiovascular profile in critically ill elderly medical patients: Prevalence, mortality and length of stay

“…Definition of medical history of cardiovascular disease was based on the criteria of the established atherosclerotic heart and vascular disease [17][18][19]: ischemic heart disease, cerebrovascular disease (stroke-ischemic or hemorrhagic non-traumatic-and transient ischemic attack), heart failure, chronic kidney failure, peripheral arterial disease and aortic aneurysm.…”

Serum 25-Hydroxyvitamin D and the Incidence of Peripheral Artery Disease in the Elderly: The Pro.V.A Study

“…Conversely, we found an incidence rate of 54 new cases of PAD per 1000 person-years, which is five times higher than the figure previously reported by Hooi et al in a study investigating the incidence of PAD in a cohort that was a mean 10 years younger than our population 23) . This very large difference is probably due to the difference in age between the two studies: our sample population had a mean age of 74 years, and the incidence of PAD is known to rise exponentially with aging, especially beyond 75 years of age 24,25) . Several cross-sectional studies have found a low tion, at both the baseline and the follow-up visits (1.5% and 3.1%, respectively), we are confident that our results were negligibly influenced by our failure to measure the serum 25OHD levels at the follow-up visit.…”

Body mass index and outcome in patients with coronary, cerebrovascular, or peripheral artery disease: findings from the FRENA registry

“…The FRENA (Factores de Riesgo y ENfermedad Arterial) registry was initiated in March 2003 to prospectively record the current clinical management and outcome of outpatients with established artery disease in Spanish hospitals [19,20]. It is an ongoing, multicenter, observational registry designed to gather and analyze data on treatment patterns and outcomes in consecutive outpatients with symptomatic ischemic disease in the heart, brain, and/or major peripheral arteries.…”