Secondary metabolites produced by callus cultures of various Ruta species

Baumert, A.; Gröger, D.; Кузовкина, И. Н.; Reisch, J.

doi:10.1007/bf00055511

Cited by 20 publications

(8 citation statements)

References 6 publications

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“…We hope that a continuation and intensification efforts in this field will lead to controllable and successful biotechnological production of specific, valuable, and as yet unknown plant chemicals. [ 102 ]…”

Section: Discussionmentioning

confidence: 99%

Current approaches toward production of secondary plant metabolites

Hussain

Fareed²,

Ansari³

et al. 2012

J Pharm Bioall Sci

544

255

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Plants are the tremendous source for the discovery of new products with medicinal importance in drug development. Today several distinct chemicals derived from plants are important drugs, which are currently used in one or more countries in the world. Secondary metabolites are economically important as drugs, flavor and fragrances, dye and pigments, pesticides, and food additives. Many of the drugs sold today are simple synthetic modifications or copies of the naturally obtained substances. The evolving commercial importance of secondary metabolites has in recent years resulted in a great interest in secondary metabolism, particularly in the possibility of altering the production of bioactive plant metabolites by means of tissue culture technology. Plant cell and tissue culture technologies can be established routinely under sterile conditions from explants, such as plant leaves, stems, roots, and meristems for both the ways for multiplication and extraction of secondary metabolites. In vitro production of secondary metabolite in plant cell suspension cultures has been reported from various medicinal plants, and bioreactors are the key step for their commercial production. Based on this lime light, the present review is aimed to cover phytotherapeutic application and recent advancement for the production of some important plant pharmaceuticals.

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Section: Discussionmentioning

confidence: 99%

Current approaches toward production of secondary plant metabolites

Hussain

Fareed²,

Ansari³

et al. 2012

J Pharm Bioall Sci

544

255

View full text Add to dashboard Cite

show abstract

“…Furthermore, the presence of alkaloids such as skimmianine, γ-fagarine, rutacridone, rutacridone epoxide, gravacridone, and arborinin was reported. However, researchers have not quantified these metabolites [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Ruta chalepensis L. In Vitro Cultures as a Source of Bioactive Furanocoumarins and Furoquinoline Alkaloids

Szewczyk

Grabowski

Zych

2023

Life

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Recently, due to the decreasing areas of cultivation and climate change, the use of biotechnological methods to obtain biomass, which is a source of valuable bioactive metabolites, is becoming more and more interesting. In this study, Ruta chalepensis in vitro cultures were investigated in RITA® temporary immersion bioreactors. Biomass growth and the production of secondary metabolites in 4- and 5-week growth cycles on three variants of the Linsmaier and Skoog (LS) medium (naphthyl-1-acetic acid/6-benzylaminopurine (NAA/BAP): 0.5/1.0, 0.1/0.1, and 1.0/1.0 mg/L) were analyzed. Using high-performance liquid chromatography of methanolic extracts of biomass, the presence of linear furanocoumarins (bergapten, isoimperatorin, isopimpinellin, psoralen, and xanthotoxin) and furoquinoline alkaloids (γ-fagarine, 7-isopentenyloxy-γ-fagarine, and skimmianine) was confirmed. The highest content of linear furanocoumarins (1170 mg/100 g DW (dry weight)) was observed in the LS medium variant containing 0.5/1.0 mg/L NAA/BAP (4-week growth cycle). The highest content of furoquinoline alkaloids (449 mg/100 g DW) was observed in the LS medium variant containing 0.1/0.1 mg/L NAA/BAP (5-week growth cycle). Hence, R. chalepensis bioreactor cultures may be used as a biotechnological source of linear furanocoumarins (xanthotoxin and bergapten) and furoquinoline alkaloids (skimmianine and γ-fagarine).

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“…Thus plant suspension cultures provide a valuable platform for the production of high-value secondary metabolites and other substances of commercial interest [37]. Various workers have reported the production of secondary metabolites from callus culture [37][38][39][40][41]. Successful attempts to produce the valuable pharmaceuticals in relatively large quantities by callus and cell cultures have been achieved.…”

Section: Callus and Cell Suspension Culturementioning

confidence: 99%

Application of Plant Cell and Tissue Culture for the Production of Phytochemicals in Medicinal Plants

Pant

2014

Advances in Experimental Medicine and Biology

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Approximately 80% of the world inhabitants depend on the medicinal plants in the form of traditional formulations for their primary health care system well as in the treatment of a number of diseases since the ancient time. Many commercially used drugs have come from the information of indigenous knowledge of plants and their folk uses. Linking of the indigenous knowledge of medicinal plants to modern research activities provides a new reliable approach, for the discovery of novel drugs much more effectively than with random collection. Increase in population and increasing demand of plant products along with illegal trade are causing depletion of medicinal plants and many are threatened in natural habitat. Plant tissue culture technique has proved potential alternative for the production of desirable bioactive components from plants, to produce the enough amounts of plant material that is needed and for the conservation of threatened species. Different plant tissue culture systems have been extensively studied to improve and enhance the production of plant chemicals in various medicinal plants.

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Secondary metabolites produced by callus cultures of various Ruta species

Cited by 20 publications

References 6 publications

Current approaches toward production of secondary plant metabolites

Current approaches toward production of secondary plant metabolites

Ruta chalepensis L. In Vitro Cultures as a Source of Bioactive Furanocoumarins and Furoquinoline Alkaloids

Application of Plant Cell and Tissue Culture for the Production of Phytochemicals in Medicinal Plants

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