Current approaches toward production of secondary plant metabolites

Abstract

Plants are the tremendous source for the discovery of new products with medicinal importance in drug development. Today several distinct chemicals derived from plants are important drugs, which are currently used in one or more countries in the world. Secondary metabolites are economically important as drugs, flavor and fragrances, dye and pigments, pesticides, and food additives. Many of the drugs sold today are simple synthetic modifications or copies of the naturally obtained substances. The evolving commercial importance of secondary metabolites has in recent years resulted in a great interest in secondary metabolism, particularly in the possibility of altering the production of bioactive plant metabolites by means of tissue culture technology. Plant cell and tissue culture technologies can be established routinely under sterile conditions from explants, such as plant leaves, stems, roots, and meristems for both the ways for multiplication and extraction of secondary metabolites. In vitro production of secondary metabolite in plant cell suspension cultures has been reported from various medicinal plants, and bioreactors are the key step for their commercial production. Based on this lime light, the present review is aimed to cover phytotherapeutic application and recent advancement for the production of some important plant pharmaceuticals.

Isolation and Identification of Streptomyces ramulosus from Soil and Determination of Antimicrobial Property of its Pigment

“…In recent years, secondary metabolites, pigments of microorganisms, and their biosynthesis pathways have been the subject of much attention (13). Scientifically, fermentation of microorganisms, such as fungi and bacteria could be a valuable source for the production of colored substances, thus looking for environmentally friendly renewable resources is an essential need for the production of colored substances (14).…”

Histochemical Screening of Leaves Compared to in situ and in vitro Calluses of Solanum aculeatissimum Jacq.

“…Yendo et al (2010) and Karuppusamy (2009) assert that some strategies have been used for improving the production of metabolites in cultures based on the principle of increasing the yield of the metabolite of interest. Hussain et al (2012) report that the use of calluses has great potential in the production of a variety of secondary metabolites because the production becomes more reliable, simple and predictable.…”

Pharmagnostic Potentialities of Ceropegia Bulbosa Roxb. Var. Lushii (Grah.) HOOK.F.: An Endangered Plant From Thar Desert, Rajasthan, India

“…The preliminary phytochemical screening tests may be separation of pharmacologically active chemical compounds 18 . Secondary metabolites are economically important as drugs, flavor and fragrances, dye and pigments, pesticides, and food additives 19,20 . The plant under study showed presence of various secondary metabolites with important biological activities ( Table 1).…”