Secondary Metabolites of<i>Hypericum leptophyllum</i>Hochst., an Endemic Turkish Species

Camas, Necdet; Radušienė, Jolita; Stanius, Žydrūnas; Çalışkan, Ömer; Çırak, Cüneyt

doi:10.1100/2012/501027

Cited by 5 publications

(5 citation statements)

References 16 publications

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“…Therefore, it can be suggested that the antidepressant effect observed in the present work may largely be due to the chlorogenic acid and/or rutin content detected in HcMeOH. Our findings are in accordance with reports on chlorogenic acid and rutin as the main components of extracts widely recognized as antidepressants such as Hypericum extracts [ 19 – 21 ]. Moreover, in the case of Hypericum origanifolium , these two components are also the main compounds found in the crude extract, even over hypericin and hyperforin, the compounds described by far as the responsible for the antidepressant properties of Hypericum perforatum (St. John's wort) [ 22 ].…”

Section: Resultssupporting

confidence: 93%

Heteropterys cotinifolia: A Neuropharmacological and Phytochemical Approach with Possible Taxonomic Implications

Huerta-Reyes

Zamilpa

Álvarez-Chimal

et al. 2013

The Scientific World Journal

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Heteropterys cotinifolia (Malpighiaceae) has been used in traditional Mexican medicine mainly for the treatment of nervous disorders. However, the specific neuropharmacological activities responsible for this use remain to be defined. The present study evaluates the antidepressant and anxiolytic effects produced by the methanolic extract of Heteropterys cotinifolia and the influence of such effects on motor activity in ICR mice. Our results show that the methanolic extract of Heteropterys cotinifolia produces a dose-dependent antidepressant effect in the forced swimming test in mice at doses from 31 to 310 mg/kg, with no reduction of mice locomotion. However, no anxiolytic properties were observed. Our findings suggest that the main extract compounds identified as chlorogenic acid and rutin may be involved in the antidepressant effects. To our knowledge, the present study constitutes the first report of pharmacological and phytochemical data of Heteropterys cotinifolia. The presence of flavonoids in the methanolic extract of Heteropterys cotinifolia may also provide further data to characterize taxonomically this species in order to be distinguished from others species closely related and belonging to the same genus.

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Section: Resultssupporting

confidence: 93%

Heteropterys cotinifolia: A Neuropharmacological and Phytochemical Approach with Possible Taxonomic Implications

Huerta-Reyes

Zamilpa

Álvarez-Chimal

et al. 2013

The Scientific World Journal

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“…In addition, both allantoin and purines generally enhance tolerance to adverse physiological conditions ( Proietti et al, 2021 ). The phenylpropanoid pathway plays a key role in plant development and defense, as well as in the biosynthesis of flavonoids and phenolic acids ( Camas et al, 2012 ). The top 20 DCMs were shown according to the order of |log 2 (Fold change)| in the comparison of drought stress with CG ( Figure 5B ).…”

Section: Resultsmentioning

confidence: 99%

Integrated transcriptome and metabolome analyses reveal the adaptation of Antarctic moss Pohlia nutans to drought stress

Fang

Zhang

et al. 2022

Front. Plant Sci.

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Most regions of the Antarctic continent are experiencing increased dryness due to global climate change. Mosses and lichens are the dominant vegetation of the ice-free areas of Antarctica. However, the molecular mechanisms of these Antarctic plants adapting to drought stress are less documented. Here, transcriptome and metabolome analyses were employed to reveal the responses of an Antarctic moss (Pohlia nutans subsp. LIU) to drought stress. We found that drought stress made the gametophytes turn yellow and curled, and enhanced the contents of malondialdehyde and proline, and the activities of antioxidant enzymes. Totally, 2,451 differentially expressed genes (DEGs) were uncovered under drought treatment. The representative DEGs are mainly involved in ROS-scavenging and detoxification, flavonoid metabolism pathway, plant hormone signaling pathway, lipids metabolism pathway, transcription factors and signal-related genes. Meanwhile, a total of 354 differentially changed metabolites (DCMs) were detected in the metabolome analysis. Flavonoids and lipids were the most abundant metabolites and they accounted for 41.53% of the significantly changed metabolites. In addition, integrated transcriptome and metabolome analyses revealed co-expression patterns of flavonoid and long-chain fatty acid biosynthesis genes and their metabolites. Finally, qPCR analysis demonstrated that the expression levels of stress-related genes were significantly increased. These genes included those involved in ABA signaling pathway (NCED3, PP2C, PYL, and SnAK2), jasmonate signaling pathway (AOC, AOS, JAZ, and OPR), flavonoid pathway (CHS, F3’,5’H, F3H, FLS, FNS, and UFGT), antioxidant and detoxifying functions (POD, GSH-Px, Prx and DTX), and transcription factors (ERF and DREB). In summary, we speculated that P. nutans were highly dependent on ABA and jasmonate signaling pathways, ROS scavenging, flavonoids and fatty acid metabolism in response to drought stress. These findings present an important knowledge for assessing the impact of coastal climate change on Antarctic basal plants.

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“…It is reported that the genera Hypericum , Arbutus , Abelmoschus , Zanthoxylum , Houttuynia , etc. are rich in Hyp, and it has been extracted from over 30 herbal plants [ 14 , 19 , 20 , 21 , 22 , 23 , 24 ].…”

Section: Phytochemistry Of Hyperosidementioning

confidence: 99%

“…The leaf parts of the plant showed larger amount of Hyp than the parts of the flower and stem. In addition, the content of Hyp in Hypericum perforatum was superior over that in Hypericum leptophyllum [ 24 ]. Similarly, 96% ethanol extract of Hypericum perforatum showed higher contents of Hyp compared with rutin and quercetin [ 23 ].…”

Section: Phytochemistry Of Hyperosidementioning

confidence: 99%

Hyperoside as a Potential Natural Product Targeting Oxidative Stress in Liver Diseases

Jang

2022

Antioxidants

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Hyperoside (Hyp), also known as quercetin-3-O-galactoside or 3-O-β-D-galactopyranosyl, is a well-known flavonol glycoside that is abundant in various fruits, vegetables, and medicinal plants. Hyp has been suggested to exhibit a wide range of biological actions, including cardiovascular, renal, neuroprotective, antifungal, antifibrotic, and anticancer effects. Accumulating evidence supports the pharmacological activities of Hyp in improving liver pathophysiology. Hence, the present literature review aims to summarize preclinical data suggesting the beneficial effects and underlying mechanisms of Hyp. In addition, our study focuses on hepatic antioxidant defense signaling to assess the underlying mechanisms of the biological actions of Hyp that are closely associated with liver diseases. Experimental findings from an up-to-date search showed that Hyp possesses hepatoprotective, antiviral, antisteatotic, anti-inflammatory, antifibrotic, and anticancer activities in cellular and animal models related to liver dysfunction by enhancing antioxidant responses. In particular, hepatocellular antioxidant defense via activation of erythroid-related nuclear factor 2 by Hyp chiefly explains how this compound acts as a therapeutic agent in liver diseases. Thus, this review emphasizes the therapeutic potential of Hyp as a strong antioxidative substance that plays a crucial role in the regulation of various liver disorders during their pathogenesis.

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Secondary Metabolites ofHypericum leptophyllumHochst., an Endemic Turkish Species

Cited by 5 publications

References 16 publications

Heteropterys cotinifolia: A Neuropharmacological and Phytochemical Approach with Possible Taxonomic Implications

Heteropterys cotinifolia: A Neuropharmacological and Phytochemical Approach with Possible Taxonomic Implications

Integrated transcriptome and metabolome analyses reveal the adaptation of Antarctic moss Pohlia nutans to drought stress

Hyperoside as a Potential Natural Product Targeting Oxidative Stress in Liver Diseases

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