Secondary metabolites ofCentaurea calolepisand evaluation of cnicin for anti-inflammatory, antioxidant, and cytotoxic activities

Abstract

This is the first detailed report of secondary metabolites of C. calolepis. Evaluation of biological activity of cnicin establishes the potential of this compound as an anti-inflammatory and cytotoxic agent.

Anti-Inflammatory Properties of Flavone di-C-Glycosides as Active Principles of Camellia Mistletoe, Korthalsella japonica

“…The 1 H NMR at 60°C revealed a 3′,4′,5,7-tetra-hydroxyl-substituted flavone from the aromatic spin systems: δ H 7.43 (s), 6.83 (d, J =8.1 Hz), and 7.46 (d, J =8.0 Hz), corresponding to H-2′, H-5′, and H-6′, respectively, and δ H 6.57 (s) corresponding to H-3 (Table 2). The hexosides were assigned as C- β - d -glucosides because the characteristic chemical shift and coupling constant were identical with that found in the literature (Erel et al ., 2011). The hexoside linkage was also assigned to C-6 and C-8 because the vicinal coupling constants were 8.0–9.7 Hz, including the anomeric protons at δ H 4.75 (d, J =9.6 Hz) of 6-C- β -Glc and δ H 4.86 (d, J =9.7 Hz) of 8-C- β -Glc, and H-2″ at δ H 3.77 (brs) of 6-C- β -Glc and δ H 3.74 (brs) of 8-C- β -Glc.…”

“…The chemical structure of the isolated compounds from KJ were elucidated by comparing their physicochemical data including UV/Vis spectra, MS and MS/MS data, and 1 H-NMR spectra with those previously described in the literature (Suzuki et al ., 2003; Xie et al ., 2003; Erel et al ., 2011). The compounds were identified as lucenin-2, vicenin-2, and stellarin-2 (KJ-1, KJ-2, and KJ-3, respectively).…”

“…The proton at δ H 6.69 (s) corresponded to H-3 (Table 2). The hexosides were also assigned as C- β - d -glucosides because of the characteristic chemical shift and coupling constant (Xie et al ., 2003; Erel et al ., 2011). Similar to the other compounds, the hexosides linkage was assigned to C-6 and C-8.…”

Cytotoxic and apoptotic effects of endemic Centaurea fenzlii Reichardt on the MCF-7 breast cancer cell line

“…Many Centaurea species are used traditionally for medicinal purposes, including Centaurea pulchella, Centaurea drabifolia, Centaurea triumfettii, Centaurea depressa, and Centaurea virgate. Various biological activities of the members of the genus Centaurea L. have been reported previously, such as cytogenetic (Radic et al, 2005), antiinflammatory (Garbacki et al, 1999;Erel et al, 2011Erel et al, , 2014, anticancer , and cytotoxic activities (Seghiri et al, 2009;Ahmed and Kamel, 2014). The chemical composition of the members of this genus was also reported in other studies (Dural et al, 2003;Beltagy, 2015).…”

Phytochemical profile and some biological activities of three Centaurea species from Turkey

“…Some of the compounds obtained from other Centaurea species include quercetin from C. omphalotricha [11], luteolin and apigenin and kaempferol from C. urvillei subsp. urvillei [12], rutin and chlorogenic acid from C. calolepis [13], protocatechuic acid from C. isaurica [14], chlorogenic acid from C. cadmea [15], and C. isaurica [14], vanillin from C. sadleriana [16]. To the best of our knowledge, none of these earlier studies used LC-MS/MS in determination of phytochemical compositions of the plant species.…”