Secondary metabolites of Hypericum orientale L. growing in Turkey: variation among populations and plant parts

Çırak, Cüneyt; Radušienė, Jolita; Stanius, Žydrūnas; Camas, Necdet; Çalışkan, Ömer; Odabas, Mehmet Serhat

doi:10.1007/s11738-012-0928-8

Cited by 26 publications

(9 citation statements)

References 25 publications

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“…Especially 8 dS/m salt treatment significantly decreased (Cirak et al 2012;Cirak and Bertoli 2013). It was also observed that the negative effects of salt treatments on plant development were more distinctive on underground parts.…”

Section: Resultsmentioning

confidence: 76%

Effect of Salt Stress and Irrigation Water on Growth and Development of Sweet Basil (Ocimum basilicum L.)

et al. 2017

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This study was conducted to assess the influence of different salinity and irrigation water treatments on the growth and development of sweet basil (Ocimum basilicum L.). Five salinity levels (0.4, 1.00, 2.50, 4.00 and 8.00 dSm-1) and three different irrigation water regimes (80, 100, 120% of full irrigation) were applied in a factorial design with three replications. Dry root weight, aerial part dry weight and aerial part/root ratio were determined and evaluated as experimental parameters at the end of growing period. Results revealed significant decreases in yields with increasing salinity levels. However, basil managed to survive high salt stress. With increasing salinity levels, decreases in growth were higher in roots than in leaves. Changes in the amount of irrigation water also significantly affected the evaluated parameters.

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Section: Resultsmentioning

confidence: 76%

Effect of Salt Stress and Irrigation Water on Growth and Development of Sweet Basil (Ocimum basilicum L.)

et al. 2017

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“…Some studies have found distributions of defensive compounds like those found in the leaves and flowers of P. virgatus (e.g. Cirak et al 2012), while others have found that the secondary metabolite content of leaves is similar to that of flowers (Jamieson and Bowers 2010). Furthermore, plant parts may differ in their β-glucosidases, which play an important role in the activation of IGs (Pankoke et al 2013).…”

Section: Resultsmentioning

confidence: 99%

The Perennial Penstemon: Variation in Defensive Chemistry Across Years, Populations, and Tissues

Kelly

Bowers

2017

J Chem Ecol

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Plants produce a variety of secondary metabolites that function as a defense against their natural enemies. Production of these secondary metabolites is genetically controlled, but is also phenotypically plastic and varies in response to both biotic and abiotic factors. Therefore, plant species may vary widely in their chemical defenses and such variation can be evident at temporal, spatial and tissue levels. Focusing on the chemical defenses of a native Colorado wildflower, Penstemon virgatus, we assessed the variation in iridoid glycoside (IG) content across two non-consecutive growing seasons, six natural populations and three tissue types: leaves, stems and flowers. Our results indicate that P. virgatus plants contain high concentrations of IGs (mean = 23.36% dry weight of leaves) and that IGs were differentially allocated among tissue types. Leaves contained the highest concentration of IGs, which varied quantitatively between sampling years, among plant populations, and plant parts. We also quantified leaf herbivore damage at all six populations but we found very little herbivore damage. Our study indicates that the IG concentrations of P. virgatus plants are both spatially and temporally variable. Furthermore, the high concentrations of secondary metabolites combined with the low levels of damage suggest that these plants are well defended against generalist herbivores.

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“…The leaves and flowers of SJW obtained from a local producer (Cooperative of Daeho-dong, Naju, Korea) were used for this study because the compounds, including hyperforin, hypericin, chlorogenic acid, hyperoside, and quercetin, are mainly present in those parts of the plant [46]. A voucher specimen (identification number: JBF-FRI-B-2012-0001) of the plant used in our experiment was deposited at the Jeonnam Biofood Technology Center, Korea.…”

Section: Sample Preparationmentioning

confidence: 99%

Estrogenic Activity of Hyperforin in MCF-7 Human Breast Cancer Cells Transfected with Estrogen Receptor

Kwon

Cho

et al. 2016

Planta Med

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Hyperforin, a major active compound of St.?John?s wort extract, affects estrogenic activity. In this study, the compound evoked estrogen response element-dependent luciferase activity and cell proliferation in MCF-7 cells. Hyperforin-induced cell proliferation was significantly inhibited by the estrogen receptor antagonist ICI 182,780. These results suggested that hyperforin had estrogenic and cell proliferation activities, which were stimulated via the estrogen receptor. Compared to 17?-estradiol, hyperforin showed significantly lower estrogenic activity and cell proliferation. The mechanism underlying the estrogenic activity of hyperforin was unknown, therefore, in this study, for the first time, the expression and post-translational modification of proteins were determined and compared among control, 17?-estradiol-treated, and hyperforin-treated cells using proteomic techniques. A total of 453 proteins were identified, of which 282 proteins were significantly modulated in hyperforin-treated cells compared to 17?-estradiol-treated cells. Ingenuity pathway analysis also demonstrated that hyperforin treatment induced less cell proliferation than 17?-estradiol by downregulating estrogen receptor 1. Protein network analysis showed that cell proliferation was regulated mainly by cyclin D1 and extracellular signal-regulated kinases. In conclusion, although, hyperforin exhibited lower estrogenic activity than 17?-estradiol, the compound induced lower levels of cancer cell proliferation in vitro.

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Secondary metabolites of Hypericum orientale L. growing in Turkey: variation among populations and plant parts

Cited by 26 publications

References 25 publications

Effect of Salt Stress and Irrigation Water on Growth and Development of Sweet Basil (Ocimum basilicum L.)

Effect of Salt Stress and Irrigation Water on Growth and Development of Sweet Basil (Ocimum basilicum L.)

The Perennial Penstemon: Variation in Defensive Chemistry Across Years, Populations, and Tissues

Estrogenic Activity of Hyperforin in MCF-7 Human Breast Cancer Cells Transfected with Estrogen Receptor

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