Secondary Metabolites from the Soft Coral Sinularia arborea

Chen, Kuan Hua; Dai, Chang‐Feng; Lu, Mei‐Chin; Li, Jan Jung; Chen, Jih Jung; Chang, Yu Chia; Su, Yin Di; Wang, Wei Hsien; Sung, Ping Jyun

doi:10.3390/md11093372

Cited by 17 publications

(11 citation statements)

References 7 publications

(13 reference statements)

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“…Based on our previous and other studies from the cytotoxicity, there are different tumor cell lines (include MOLT-4, SUP-T1, DLD-1, LNCaP and MCF7 cells) which were obtained from ATCC [ 12 , 13 , 14 , 15 , 16 ]. Cells were maintained in RPMI 1640 medium supplemented with 10% fetal calf serum, 2 mM glutamine and antibiotics (100 units/mL penicillin and 100 μg/mL streptomycin) at 37 °C in a humidified atmosphere of 5% CO 2 .…”

Section: Methodsmentioning

confidence: 99%

New Anti-Inflammatory Cembranes from the Cultured Soft Coral Nephthea columnaris

et al. 2015

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Two new cembranes, columnariols A (1) and B (2), were isolated from the cultured soft coral Nephthea columnaris. The structures of cembranes 1 and 2 were elucidated by spectroscopic methods. In the anti-inflammatory effects test, cembranes 1 and 2 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. Compound 1 exhibited moderate cytotoxicity toward LNCaP cells with an IC50 value of 9.80 μg/mL.

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Section: Methodsmentioning

confidence: 99%

New Anti-Inflammatory Cembranes from the Cultured Soft Coral Nephthea columnaris

et al. 2015

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“…A non‐cytotoxic 7‐hydroperoxycembranoid, arbolide A ( 48 ) (Figure ), was isolated from the soft coral S. arborea , collected from the coast of Southern Taiwan. The structure of cembranoid 48 was elucidated by spectroscopic methods …”

Section: Alcyonaceamentioning

confidence: 99%

Hydroperoxyditerpenoids from Octocorals

Sheu

Peng

Fang

et al. 2019

Israel Journal of Chemistry

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The structures, names, bioactivities, and references of 75 marine diterpenoids from octocorals possessing a hydroperoxy group, including 46 cembranes, 8 eunicellins, 5 briaranes, 5 dolabellanes, 4 germacranes, 3 xenicins, 2 caryophyllanes, 1 decalin, and 1 pseudopterosin, are summarized in this review article. All the hydroperoxyditerpenoids mentioned in this review were isolated from octocorals from Alcyonacea (Briareum excavatum, Briareum polyanthes, Briareum violaceum, Briareum sp., Cespitularia sp., Cladiella tuberculosa, Cladiella sp., Clavularia inflata, Klyxum simplex, Lemnalia sp., Lobophytum crassum, Lobophytum sp., Nephthea pacifica, Sarcophyton cherbonnieri, Sarcophyton crassocaule, Sarcophyton glaucum, Sarcophyton mililatensis, Sarcophyton trocheliophorum, Sarcophyton sp., Sinularia arborea, Sinularia erecta, Sinilaria flexibilis, Sinularia gibberosa, Sinularia manaarensis, Xenia umbellata) and Gorgonacea (Astrogorgia sp., Eunicea calyculata, Eunicea pinta, Eunicea succinea, Eunicea sp., Pseudopterogorgia sp.). Among these isolates, 41 compounds exhibited potential biomedical activities, including cytotoxicity, antimalarial activity, anti‐inflammatory activity, and antibacterial activity.

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“…In previous studies on the chemical constituents of the soft coral Sinularia arborea [1], six new diterpenoids, arbolides A-C, (+)-sarcophytol T, sinularbols A and B, along with a trihydroxysteroid, crassarosterol A, were isolated [2][3][4]. In the continuing studies on this interesting species, a mixture of diastereoisomers, 5-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)-2-methyl-pentanoic acid methyl ester (1), was isolated (Scheme 1).…”

Section: M822 (Page 2)mentioning

confidence: 99%