5-(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)-2-methyl-pentanoic Acid Methyl Ester

Chen, Kuan‐Hua; Dai, Chang‐Feng; Hwang, Tsong‐Long; Sung, Ping‐Jyun

doi:10.3390/m822

Cited by 2 publications

(2 citation statements)

References 6 publications

(7 reference statements)

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“…Apo-9'-fucoxanthinone (97), isolated from a gorgonian coral Pinnigorgia sp., displayed a significant inhibitory effect on the release of elastase by human neutrophils, with an IC 50 value of 5.75 µM [113] (Figure 16). effect on the generation of superoxide anion by human neutrophils with an IC50 value of 7.42 μM but was inactive toward elastase release [111].…”

Section: Miscellaneousmentioning

confidence: 97%

“…5-(6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-yl)-2-methyl-pentanoic acid methyl ester (94), an α-tocopherol derivative, was isolated from the soft coral Sinularia arborea for the first time. The bioassay revealed that the metabolite displayed a significant inhibitory effect on the generation of superoxide anion by human neutrophils with an IC 50 value of 7.42 µM but was inactive toward elastase release [111].…”

Section: Miscellaneousmentioning

confidence: 99%

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Unlocking the Potential of Octocoral-Derived Secondary Metabolites against Neutrophilic Inflammatory Response

Nguyen,

El-Shazly,

Chen

et al. 2023

Marine Drugs

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Inflammation is a critical defense mechanism that is utilized by the body to protect itself against pathogens and other noxious invaders. However, if the inflammatory response becomes exaggerated or uncontrollable, its original protective role is not only demolished but it also becomes detrimental to the affected tissues or even to the entire body. Thus, regulating the inflammatory process is crucial to ensure that it is resolved promptly to prevent any subsequent damage. The role of neutrophils in inflammation has been highlighted in recent decades by a plethora of studies focusing on neutrophilic inflammatory diseases as well as the mechanisms to regulate the activity of neutrophils during the overwhelmed inflammatory process. As natural products have demonstrated promising effects in a wide range of pharmacological activities, they have been investigated for the discovery of new anti-inflammatory therapeutics to overcome the drawbacks of current synthetic agents. Octocorals have attracted scientists as a plentiful source of novel and intriguing marine scaffolds that exhibit many pharmacological activities, including anti-inflammatory effects. In this review, we aim to provide a summary of the neutrophilic anti-inflammatory properties of these marine organisms that were demonstrated in 46 studies from 1995 to the present (April 2023). We hope the present work offers a comprehensive overview of the anti-inflammatory potential of octocorals and encourages researchers to identify promising leads among numerous compounds isolated from octocorals over the past few decades to be further developed into anti-inflammatory therapeutic agents.

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Section: Miscellaneousmentioning

confidence: 97%

Section: Miscellaneousmentioning

confidence: 99%

Unlocking the Potential of Octocoral-Derived Secondary Metabolites against Neutrophilic Inflammatory Response

Nguyen,

El-Shazly,

Chen

et al. 2023

Marine Drugs

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Exploring the Potential Bioactive Properties of Marine Natural Products

Zarena¹

2019

CBC

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Background: The marine world is highly diversified and is of great importance for its sustainable utilization as resources for human life. Although marine resource economy has its own share in the international market, there is only a handful of research occurring, the probability of not being completely explored. It has now become virtually possible to characterize the metabolites by bioanalytical techniques and molecular biology methodology. The marine biomes harbour largely diatoms, bacteria, fungi, actinomycetes, and cyanobacteria that are harnessed for their rich structurally diverse secondary metabolites. Recently, sponges and algae have gained commercial importance. Focuses are now shifting towards ascomycota, actinobacteria, cyanobacteria and other classes due to the advanced technology in extraction of the active components from these phyla and deeper exploration of the oceans. Method: A vast report on marine natural products have been regularly updated and published which clearly indicates the immense research undertaken in ocean flora and fauna. Herein we focus on providing information on the potential uses of marine natural products as bioactive agents in the last five years. The data were collected from research and review articles from peer-reviewed journals. Results: A total of 128 articles are citied in the present review covering broad spectrum of marine organism and their importance in the field of medical biology. Information on source organisms, collection sites, was assembled and a total of 120 biologically important compounds are described here. Conclusion: The present study provides information to bioprospecting efforts in the field of marine science. Herein, I have emphasized diverse biological activities isolated from marine microbes to invertebrate against many pathogenic microorganisms and cancer, thus making marine-derived natural products valuable commodities. Future prospects for the discovery of new marine products and process development could add to the economic importance.

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5-(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)-2-methyl-pentanoic Acid Methyl Ester

Cited by 2 publications

References 6 publications

Unlocking the Potential of Octocoral-Derived Secondary Metabolites against Neutrophilic Inflammatory Response

Unlocking the Potential of Octocoral-Derived Secondary Metabolites against Neutrophilic Inflammatory Response

Exploring the Potential Bioactive Properties of Marine Natural Products

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