Secondary Metabolites from the Endophytic Fungus Xylaria sp. hg1009

Chen, Rong; Tang, Jianwei; Li, Xing-Ren; Liu, Miao; Ding, Wenping; Zhou, Yuanfei; Wang, Weiguang; Du, Xue; Sun, Han‐Dong; Puno, Pema‐Tenzin

doi:10.1007/s13659-018-0158-x

Cited by 8 publications

(6 citation statements)

References 30 publications

(25 reference statements)

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“…Another occurrence of pyranones was reported from an endophytic Xylaria sp. and named Xylariahgins A ( 42 )–F [ 64 ]. An assessment of their cytotoxicity against human tumor cell lines such as HL-60, A-549, and MCF-7 was unsuccessful.…”

Section: Novel Secondary Metabolites From the Xylariaceae Smentioning

confidence: 99%

Recent progress in biodiversity research on the Xylariales and their secondary metabolism

Becker

Stadler

2020

J Antibiot

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The families Xylariaceae and Hypoxylaceae (Xylariales, Ascomycota) represent one of the most prolific lineages of secondary metabolite producers. Like many other fungal taxa, they exhibit their highest diversity in the tropics. The stromata as well as the mycelial cultures of these fungi (the latter of which are frequently being isolated as endophytes of seed plants) have given rise to the discovery of many unprecedented secondary metabolites. Some of those served as lead compounds for development of pharmaceuticals and agrochemicals. Recently, the endophytic Xylariales have also come in the focus of biological control, since some of their species show strong antagonistic effects against fungal and other pathogens. New compounds, including volatiles as well as nonvolatiles, are steadily being discovered from these ascomycetes, and polythetic taxonomy now allows for elucidation of the life cycle of the endophytes for the first time. Moreover, recently high-quality genome sequences of some strains have become available, which facilitates phylogenomic studies as well as the elucidation of the biosynthetic gene clusters (BGC) as a starting point for synthetic biotechnology approaches. In this review, we summarize recent findings, focusing on the publications of the past 3 years.

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Section: Novel Secondary Metabolites From the Xylariaceae Smentioning

confidence: 99%

Recent progress in biodiversity research on the Xylariales and their secondary metabolism

Becker

Stadler

2020

J Antibiot

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“…ex Hemsl. ) Diels, which may participate in the host defense system because its secondary metabolites exhibit moderate and broad-spectrum antibacterial activities Citrus reticulata L .…”

Section: Resultsmentioning

confidence: 99%

“…Diels, which may participate in the host defense system because its secondary metabolites exhibit moderate and broad-spectrum antibacterial activities. 67 Dothideomycetes has been reported to enhance plant drought resistance and promote plant growth by improving antioxidant enzyme activity in Citrus reticulata L. 68 The fungal endophyte Penicillium has been reported to positively enhance host tolerance to heavy metal stress and increase nutrient absorption. 69,70 Foliar application of ZnO QDs could help to enrich a variety of beneficial endophytic colonizing fungi in pumpkin and producing direct (e.g., promoting nutrient bioaccessibility and plant hormone production) and indirect benefits (e.g., induced resistance, production of antibiotics and secondary metabolites, improved tolerances to abiotic and biotic stresses) that promoted overall plant health.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Foliar Applied ZnO Quantum Dots Boost Pumpkin (Cucurbita moschata Duch.) Growth and Positively Alter Endophytic and Rhizosphere Microbial Communities

Liang

et al. 2023

ACS Sustainable Chem. Eng.

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Systematic understanding of the impact of nanomaterials (NMs) on the health and activity of plant-associated microorganisms is required for sustainable development of efficient nano-enabled agrochemicals. Zinc (Zn) is an essential micronutrient for plant growth and development. It plays a vital role in various physiological processes, including enzyme activation, protein synthesis, cell division, etc. The present study investigated the effects of foliar exposure to different sizes of ZnO particles, including ZnO quantum dots (ZnO QDs, 4.06 nm), ZnO nanoparticles (ZnO NPs, 60.0 nm), bulk-scale ZnO particles (ZnO BPs, 464.5 nm), and Zn ions at an equivalent Zn molar concentration (0.61 mM) on the endophytic and rhizosphere microbial communities of pumpkin seedlings. ZnO QDs increased the total plant biomass by 24.6% as compared to the control. ZnO QDs also increased the contents of total chlorophyll and carotenoids, elevated micronutrient (Zn, Fe, and B) uptake, and triggered the activities of antioxidant enzymes, such as peroxidase (POD), polyphenol oxidase (PPO), and catalase (CAT), as compared to controls. The composition and diversity of the endophytic and rhizosphere bacterial or fungal communities were significantly altered as a function of ZnO NM size, and a significant difference between the control and ZnO treatments was also evident. Linear discriminant effect size analysis (LEfSe) shows that the putative beneficial host microbes Steroidobacter (relative abundance, RA: 1.05%) and Paenibacillus (RA: 0.59%) were enriched in pumpkin seedlings treated with ZnO QDs, which may lead to greater plant growth, nutrient acquisition, and stress resistance. Cooccurrence networks indicate that ZnO QDs increased both node and link numbers of the bacterial networks by 46.94 and 123.38% in the roots, which could further stabilize the microbial community and confer resistance to environmental disturbance. Our overall findings demonstrate that ZnO QDs could enhance plant growth both directly by improving physiological performances and indirectly by modulating beneficial endophytic and rhizosphere microorganisms. Thus, nano-enabled strategies can be a promising and sustainable approach to increase crop growth and resistance to stress.

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“…Xylariahgin F ( 210 ) was isolated from the Isodon sculponeatus -derived fungus Xylaria sp. [ 66 ]. Two new compounds, including (4 S )-3,4-dihydro-4-(4-hydroxybenzyl)-3-oxo-1H-pyrrolo [2,1- c ][1,4]oxazine-6-carbaldehyde ( 211 ) and methyl (2 S )-2-[2-formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl]-3-(4-hydr-oxyphenyl)propanate ( 212 ), were isolated from the Wuling Shen-derived fungus Xylaria nigripes [ 67 ].…”

Section: Structural and Biological Activity Studiesmentioning

confidence: 99%

Structures and Biological Activities of Secondary Metabolites from Xylaria spp.

Chen,

Yu,

Chen

et al. 2024

JoF

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The fungus genus Xylaria is an important source of drug discoveries in scientific fields and in the pharmaceutical industry due to its potential to produce a variety of structured novel and bioactive secondary metabolites. This review prioritizes the structures of the secondary metabolites of Xylaria spp. from 1994 to January 2024 and their relevant biological activities. A total of 445 new compounds, including terpenoids, nitrogen-containing compounds, polyketides, lactones, and other classes, are presented in this review. Remarkably, among these compounds, 177 compounds show various biological activities, including cytotoxic, antimicrobial, anti-inflammatory, antifungal, immunosuppressive, and enzyme-inhibitory activities. This paper will guide further investigations into the structures of novel and potent active natural products derived from Xylaria and their potential contributions to the future development of new natural drug products in the agricultural and medicinal fields.

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Secondary Metabolites from the Endophytic Fungus Xylaria sp. hg1009

Cited by 8 publications

References 30 publications

Recent progress in biodiversity research on the Xylariales and their secondary metabolism

Recent progress in biodiversity research on the Xylariales and their secondary metabolism

Foliar Applied ZnO Quantum Dots Boost Pumpkin (Cucurbita moschata Duch.) Growth and Positively Alter Endophytic and Rhizosphere Microbial Communities

Structures and Biological Activities of Secondary Metabolites from Xylaria spp.

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