Secondary Metabolites from Polar Fractions of <i>Piper umbellatum</i>

Tabopda, Turibio Kuiate; Mitaine-Offer, Anne Claire; Miyamoto, Tomofumi; Tanaka, Chiaki; Ngadjuic, Bonaventure Tchaleu; Lacaille‐Dubois, Marie‐Aleth

doi:10.1177/1934578x1200700511

Cited by 1 publication

(2 citation statements)

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“…Aristolactam-type alkaloids were, typical compounds found in Aristolochia spp., also isolated from Piper plants. Tabopda et al suggested that the two aristolactam-type alkaloids, cepharadiones A (28) and B (29), found in some Piper plants, could be considered as chemotaxonomic markers of the genus [54]. Until now, almost 20 aristolactam-type alkaloids have been reported in Piper, some of them exhibited cytotoxic activities, e.g.…”

Section: Aristolactam-typementioning

confidence: 99%

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A Survey of the Chemical Compounds of Piper spp. (Piperaceae) and Their Biological Activities

Xiang

Shi

Liu

et al. 2016

Natural Product Communications

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The genus Piper is one of the largest genera in the Piperaceae, with most species widely distributed globally, covering all continents. To date, many Piper species have been scientifically investigated for their chemical diversities and interesting broad spectrum of bioactivities, including central nervous system (CNS), pesticidal, antifungal and antibacterial effects. This review systematically summarizes the scaffolds of the alkaloids reported, the major chemicals isolated from Piper spp., and their biological activities. Besides the alkaloids, some neolignans with rearranged skeletons show structural diversities, while the chalcones, flavonoids and kava-pyrones have some potential activities. Herein, the sesquiterpenes and phenolic compounds from Piper species and their bioactivities are also surveyed.

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Section: Aristolactam-typementioning

confidence: 99%

“…Kava-pyrones were shown to be the major active compounds, e.g. kavain (52), methysticin (53), dihydrokavain (54), and dihydromethysticin (55) [78]. It was reported that the kavapyrones, (+/-)-kavain (52) and (+)-methysticin (53) inhibited voltage-operated Na + -channels in rat CA1 hippocampal neurons [79].…”

Section: Phenolic Compoundsmentioning

confidence: 99%