A Survey of the Chemical Compounds of <i>Piper</i> spp. (Piperaceae) and Their Biological Activities

Xiang, Cai-Peng; Shi, Yueqin; Liu, Fangfang; Li, Haizhou; Zhang, Yingjun; Yang, Chong‐Ren; Xu, Min

doi:10.1177/1934578x1601100948

Cited by 10 publications

(9 citation statements)

References 85 publications

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“…Notably, glycosides (such as saponins), as well as most large phenolic compounds are two very large groups of secondary metabolites with confirmed biological activity against herbivores and pathogens that cannot be analyzed using traditional GC–MS approaches. However, there have been few published reports of these compounds present in Piper species or of their role in Piper –herbivore/pathogen interactions (but please refer to: Kumar et al, 2014; Li et al, 2019; Sundang et al, 2012; Tamuly et al, 2014; Xiang et al, 2016). Nevertheless, some phenolic compounds have been found in the leaves of a few Piper species in La Selva, including two that are part of our experimental communities (Baldwin & Schultz, 1988; Conde‐Hernandez & Guerrero‐Beltran, 2014; Diaz et al, 2012; Maxwell et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Testing the role of local plant chemical diversity on plant–herbivore interactions and plant species coexistence

Salazar

Marquis

2022

Ecology

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Accumulating evidence suggests that herbivorous insects influence the local composition and richness of Neotropical plant species, particularly in species‐rich genera. Species richness, phylogenetic diversity, and chemical diversity all influence the ability of insect herbivores to find and utilize their hosts. The relative impact of these components of diversity on species coexistence and plant–herbivore interactions is not well understood. We constructed 60 local communities of up to 13 species of Piper (Piperaceae) in native, mature forest at a lowland wet forest location in Costa Rica. The species composition of each community was chosen such that species richness, phylogenetic diversity, and GCMS‐based chemical diversity were varied independently among communities. We predicted that chemical diversity would most strongly affect the communities across time, with smaller effects of taxonomic and phylogenetic diversity. At 13 months after the experimental planting, we assessed survivorship of each cutting, measured total leaf area loss of the survivors, leaf area loss to generalist and specialist herbivorous insect species, and local extinction of species. Generalist and specialist herbivory decreased with increasing levels of species richness and phylogenetic diversity, respectively. Surprisingly, there was no independent effect of chemical diversity on any of the three measures of herbivore damage. Nevertheless, plots with a higher chemical and phylogenetic diversity showed decreased plant mortality and local species extinction. Overall, our results suggested that both chemical and phylogenetic similarity are important factors in the assembly and maintenance of tropical plant communities. The fact that chemical diversity influences plant mortality suggests that leaf herbivores, and possibly other plant natural enemies, could increase plant diversity via the selective mortality of similar chemotypes.

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Section: Discussionmentioning

confidence: 99%

Testing the role of local plant chemical diversity on plant–herbivore interactions and plant species coexistence

Salazar

Marquis

2022

Ecology

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“…32 Piperine also exerts an anti-proliferative effect on prostate cancer cells by inducing autophagy. [34][35][36] Kava (Piper methysticum Forst.) is an annual plant grown in the Pacific islands.…”

Section: Garlic (Allium Sativum; Liliaceae Family)mentioning

confidence: 99%

Potential of herbal medicines in cancer therapy

Nova

Hoemardani

Louisa

2021

InaJCC

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Herbal medicines have long been used for traditional treatment of diseases. Our ancestors used plants empirically as treatment and for the maintenance of health inherited from generation to generation. At present, most of the research and development of drugs is still focused on a single compound as the main compound against the treatment target. It is difficult to get a single compound chemical with high selectivity and potential but low toxicity to the target of the disease. Empiric treatment with medicinal plants is particularly a concern in cancer treatment, where treatment is currently done with chemotherapy, radiotherapy, and surgery. The active compound of herbal plants is one alternative in searching for a new anti-cancer because it is believed to have minimal side effects. Therefore, the design and development of anti-cancer drug candidate from herbal plants are increasingly in demand.

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“…In general, Piper species display a wide range of biological activities and produce a great variety of novel bioactive secondary metabolites, most of which are formed via the shikimic acid pathway [23][24][25][26]. A couple of Piper species, characteristic of the Ecuadorian flora, have been investigated by us in the past [6,21].…”

Section: Introductionmentioning

confidence: 99%

Essential Oil and Major Non-Volatile Secondary Metabolites from the Leaves of Amazonian Piper subscutatum

Ramírez

Andrade

Vidari

et al. 2021

Plants

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The essential oil and the major non-volatile secondary metabolites from the leaves of Piper subscutatum (Miq.) C. DC. (Family Piperaceae), collected in the Ecuadorian Amazon, were analyzed for the first time in the present study. The essential oil was submitted to chemical and enantioselective analyses by GC-MS and GC-FID. (E)-β-caryophyllene (25.3–25.2%), β-chamigrene (10.3–7.8%), (E)-nerolidol (8.1–7.7%), β-selinene (7.2–7.7%), δ-cadinene (2.7–3.9%), bicyclogermacrene (3.7–2.4%), and β-pinene (2.6–3.4%) were the major components. The enantioselective analysis, carried out on a β-cyclodextrin-based column, showed four scalemic mixtures in which (1R,5R)-(+)-α-pinene, (1S,5S)-(−)-β-pinene, (S)-(−)-limonene, and (1R,2S,6S,7S,8S)-(−)-α-copaene were the major enantiomers, with enantiomeric excesses of 28.8%, 77.8%, 18.4%, and 6.0%, respectively. The study was complemented with the chemical analysis of the organic fraction dissolved in the hydrolate, whose major components were 6-methyl-5-hepten-2-one (63.7–64.4%) and linalool (6.5–6.0%). Concerning the non-volatile fraction, five lignans were the major components. (–)-Beilshminol B, (–)-grandisin, (–)-3′,4′-methylenedioxy-3,4,5-trimethoxy-7,7′-epoxylignan, (–)-3′,4′-methylenedioxy-3,4,5,5′-tetramethoxy-7,7′-epoxylignan, and (–)-3,4,3′,4′-dimethylenedioxy-5,5′-dimethoxy-7,7′-epoxylignan were identified by means of NMR spectroscopy, mass spectrometry and X-ray crystallography. The absolute configuration 7S,8S,7′S,8′S was tentatively assigned to all of them.

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A Survey of the Chemical Compounds of Piper spp. (Piperaceae) and Their Biological Activities

Cited by 10 publications

References 85 publications

Testing the role of local plant chemical diversity on plant–herbivore interactions and plant species coexistence

Testing the role of local plant chemical diversity on plant–herbivore interactions and plant species coexistence

Potential of herbal medicines in cancer therapy

Essential Oil and Major Non-Volatile Secondary Metabolites from the Leaves of Amazonian Piper subscutatum

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