Secondary metabolites from fungus Alternaria sp. CIB 108

Chen, Qian Feng; Zhou, Min; Yang, Tao; Chen, Xiao Zhen; Chün, Wang; Zhang, Guo Lin; Li, Guo You

doi:10.1016/j.cclet.2011.05.036

Cited by 2 publications

(3 citation statements)

References 11 publications

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“…In addition, the structures of 3-epideoxyradicinol ( 5 ) [17], the radicinol derivative ( 6 ) [18], 4,6-dihydroxy-5-methoxy-7-methylphthalide ( 9 ) [19], 4,5,6-trihydroxy-7-methyl phthalide ( 10 ) [19], epicoccone B ( 11 ) [16], 4,6-dihydroxy-5-methoxy-7-methyl-1,3-dihydroisobenzofuran ( 12 ) [20], and 4,5,6-trihydroxy-7-methyl-1,3-dihydroisobenzofuran ( 13 ) [20] were determined by comparing the NMR data with those reported in the literature.…”

Section: Resultsmentioning

confidence: 99%

The Purification, Characterization, and Biological Activity of New Polyketides from Mangrove-Derived Endophytic Fungus Epicoccum nigrum SCNU-F0002

et al. 2019

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Six new polyketides, including one coumarin (1), two isocoumarins (2 and 3), dihydroradicinin (4), and two benzofuranone derivatives (7 and 8), together with seven known analogues (5–6 and 9–13) were isolated from the culture of the mangrove endophytic fungus Epicoccum nigrum SCNU-F0002. The structures were elucidated on the interpretation of spectroscopic data. The absolute configuration of Compounds 2 and 3 were determined by comparison of their ECD spectra with the data of their analogue dihydroisocoumarins described in the literature. The absolute configuration of 4 was determined by single-crystal X-ray diffraction. All the compounds were screened for their antioxidant, antibacterial, anti-phytopathogenic fungi and cytotoxic activities. Using a DPPH radical-scavenging assay, Compounds 10–13 showed potent antioxidant activity with IC50 values of 13.6, 12.1, 18.1, and 11.7 μg/mL, respectively. In addition, Compounds 6 and 7 showed antibacterial effects against Bacillus subtilis (ATCC 6538), Escherichia coli (ATCC 8739), and Staphylococcus aureus (ATCC 6538), with MIC values in the range of 25–50 μg/mL.

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Section: Resultsmentioning

confidence: 99%

The Purification, Characterization, and Biological Activity of New Polyketides from Mangrove-Derived Endophytic Fungus Epicoccum nigrum SCNU-F0002

et al. 2019

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“…Several metabolites are unique to one Alternaria species, but most metabolites are produced by more than one species. Occurrences of the isolated metabolites from Alternaria fungi are listed in Table 1 [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , …”

Section: Classification and Occurrencementioning

confidence: 99%

“…Host non-specific pyranone phytotoxins include radicinin ( 118 ), deoxyradicinin ( 119 ), alternaric acid ( 133 ), alternuisol ( 154 ), altertenuol ( 155 ), dehydroaltenusin ( 156 ), alternariol (AOH, 157 ), alternariol 9-methyl ether (AME, 159 ), and alternuene ( 162 ). They are very common non-specific phytotoxic metabolites of Alternaria species [ 64 , 65 , 66 , 67 , 68 , 69 , 74 , 80 , 81 , 82 , 83 , 84 , 85 ].…”

Section: Biological Activities and Functionsmentioning

confidence: 99%

Metabolites from Alternaria Fungi and Their Bioactivities

et al. 2013

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Alternaria is a cosmopolitan fungal genus widely distributing in soil and organic matter. It includes saprophytic, endophytic and pathogenic species. At least 268 metabolites from Alternaria fungi have been reported in the past few decades. They mainly include nitrogen-containing metabolites, steroids, terpenoids, pyranones, quinones, and phenolics. This review aims to briefly summarize the structurally different metabolites produced by Alternaria fungi, as well as their occurrences, biological activities and functions. Some considerations related to synthesis, biosynthesis, production and applications of the metabolites from Alternaria fungi are also discussed.

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Secondary metabolites from fungus Alternaria sp. CIB 108

Cited by 2 publications

References 11 publications

The Purification, Characterization, and Biological Activity of New Polyketides from Mangrove-Derived Endophytic Fungus Epicoccum nigrum SCNU-F0002

The Purification, Characterization, and Biological Activity of New Polyketides from Mangrove-Derived Endophytic Fungus Epicoccum nigrum SCNU-F0002

Metabolites from Alternaria Fungi and Their Bioactivities

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