Metabolites from Alternaria Fungi and Their Bioactivities

Lou, Jingfeng; Fu, Linyun; Peng, You-Liang; Zhou, Ligang

doi:10.3390/molecules18055891

Cited by 229 publications

(222 citation statements)

References 184 publications

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“…The authors postulated djalonensone to be a significant taxonomic marker of the plant species [48]. However, djalonensone is identical to alternariol 9-methyl ether (AME) which has been isolated from a series of fungi including pathogenic and endophytic fungi [1]. Thus, the significance of djalonensone (11) as an important taxonomic marker of the plant species should be reconsidered.…”

Section: Dibenzo-α-pyrones From Plantsmentioning

confidence: 99%

“…After administration of [1][2][3][4][5][6][7][8][9][10][11][12][13] C]acetate and [1,[2][3][4][5][6][7][8][9][10][11][12][13] C]acetate to cultured lichen mycobionts of Graphis spp., acetate units were incorporated into the 6H-dibenzo[b,d]pyran-6-one derivatives including alternariol (10), AME (11) and graphislactones A-F (18-23) [3]. Alternariol (10) could suffer oxidative demethylation at C-1, hydroxylation at C-4, and O-methylation at C-9 to lead formation of graphislactones E (22) and F (23).…”

Section: Biosynthesis and Biotransformationmentioning

confidence: 99%

“…They are usually isolated from fungi [1], mycobionts [2,3], plants [4,5], and animal feces containing the transformed products of plant-derived ellagitannins and ellagic acid by intestinal bacteria [6,7]. Many of them possess a wide spectrum of biological activities, spanning from toxicity on human and animals [8], cytotoxic activity [9], phytoxicity [10], antioxidant [6],…”

Section: Introductionmentioning

confidence: 99%

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Natural Dibenzo-α-Pyrones and Their Bioactivities

Mao

Sun

et al. 2014

Molecules

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Natural dibenzo-α-pyrones are an important group of metabolites derived from fungi, mycobionts, plants and animal feces. They exhibit a variety of biological activities such as toxicity on human and animals, phytotoxicity as well as cytotoxic, antioxidant, antiallergic, antimicrobial, antinematodal, and acetylcholinesterase inhibitory properties. Dibenzo-α-pyrones are biosynthesized via the polyketide pathway in microorganisms or metabolized from plant-derived ellagitannins and ellagic acid by intestinal bacteria. At least 53 dibenzo-α-pyrones have been reported in the past few decades. This mini-review aims to briefly summarize the occurrence, biosynthesis, biotransformation, as well as their biological activities and functions. Some considerations related to synthesis, production and applications of dibenzo-α-pyrones are also discussed.

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Section: Dibenzo-α-pyrones From Plantsmentioning

confidence: 99%

Section: Biosynthesis and Biotransformationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Natural Dibenzo-α-Pyrones and Their Bioactivities

Mao

Sun

et al. 2014

Molecules

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“…University of Agriculture in Krakow 29 Listopada 54,Poland in the soil (Lou et al, 2013). Many species are saprotrophs, plant pathogens or crop pathogens.…”

Section: Department Of Plant Protecion Faculty Of Biotechnology and Hmentioning

confidence: 99%

Alternaria alternata – the main causal agent of disease symptoms in juniper, rose, yew and highbush blueberry in nurseries in southern Poland

Nadziakiewicz

Kurzawińska

Mazur

et al. 2018

Folia Horticulturae

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Symptoms of discoloration and necrosis of the leaves/needles and shoots of plants are an increasingly common phenomenon in nurseries. They necessitate the withdrawal of the affected plants from sale, which has significant economic consequences. In 2010-2011, observations were conducted of the health of shrubs in nurseries of the Małopolska province. Disease symptoms were mostly found in juniper (Juniperus horizontalis 'Wiltonii'), rose (ground-cover rose 'Star Profusion'), yew (Taxus × media 'Hillii') and highbush blueberry (Vaccinium corymbosum 'Patriot'). These species were selected for further study. The affected shrubs represented more than 46% of the population of a given species. Fragments of the diseased organs: the leaves or needles, the base of the shoots, and the roots, were collected from the borderline between healthy and diseased tissue, and used to isolate and identify the microorganisms colonizing the diseased parts. The affected organs were found to be inhabited to the largest extent by the fungus Alternaria alternata (Fr.) Keissl., which accounted for 19.7 to 47.5% of the isolates from the tested species of shrubs. There were also large populations of fungi of the genera: Botrytis (up to 9.82%), Cladosporium (up to 5.66%), Colletotrichum (up to 5.13%), Fusarium (up to 18.38%), Mortierella (up to 7.26%), Pestalotia (up to 5.36%), Rhizoctonia (up to 5.36%), Sclerotinia (up to 6.99%), and Trichoderma (up to 17.09%). The fungus A. alternata, being by far the dominant pathogen, was tested for its pathogenicity for the shoots of the chosen species of shrubs. The test was conducted for 14 days in a chamber with parameters so programmed that they reflected the natural conditions at the height of the growing season. The fungus A. alternata exhibited pathogenicity for all of the tested species of shrubs. Necrosis developed on all the inoculated fragments of shoots. The surface area of necrotic lesions was larger on the shoots of juniper and blueberry.

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“…The genus Alternaria of ascomycete fungi is a major phytopathogen, comprised of 299 species, and it is found throughout the world (Kirk et al, 2008). Over 268 metabolites have been reported from different species of Alternaria, and most of them showed phytotoxic, cytotoxic, and antimicrobial properties (Lou et al, 2013). Sanodiya et al (2010) identified tenuazonic acid in A. alternata and verified its herbicidal potential against parthenium.…”

Section: Introductionmentioning

confidence: 99%

MANAGEMENT OF PARTHENIUM WEED USING METABOLITES OF Alternaria japonica

et al. 2017

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-Parthenium (Parthenium hysterophorus) is an alien invasive weed infesting many parts of the world including Pakistan. A number of herbicides have been recommended for control of this weed, but these herbicides have issues regarding human health and environmental safety. In the current study, the herbicidal potential of culture filtrates of a fungal species, namely Alternaria japonica, was evaluated against parthenium weed. The fungal species was grown in malt extract broth (MEB) and potato dextrose broth (PDB) for 15 days. Culture filtrates were obtained by passing the materials through muslin cloth followed by filtration through filter paper and then through Millipore filter paper. In laboratory bioassays, the effect of original (X) and diluted (½X) filtrates was studied on seed germination, and shoot and root growth of parthenium. In general, fungal culture filtrates prepared in either of the two growth medium significantly reduced germination and seedling growth of parthenium. However, culture filtrates prepared in potato dextrose broth showed greater herbicidal activity than those prepared in malt extract broth. Foliar spray bioassays were carried out by using culture filtrates of A. japonica prepared in potato dextrose broth. In this experiment, 1-, 2-and 3 week old parthenium seedlings were sprayed 4 times with original (X) and concentrated (2X) fungal culture filtrates, with intervals of 4 days. In general, 1 week old parthenium seedlings were highly susceptible to foliar spray of fungal metabolites. The present study concludes that culture filtrates of A. japonica prepared in potato dextrose broth contain potent herbicidal constituents for management of parthenium.Keywords: Asteraceae, congo grass, fungi, mycoherbicide, weed. Palavras-chave: Asteraceae, capim-do-congo, fungos, mico-herbicida, planta daninha. RESUMO -A losna-branca (Parthenium hysterophorus) é uma espécie invasora não nativa que infesta várias partes do mundo, incluindo o

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Metabolites from Alternaria Fungi and Their Bioactivities

Cited by 229 publications

References 184 publications

Natural Dibenzo-α-Pyrones and Their Bioactivities

Natural Dibenzo-α-Pyrones and Their Bioactivities

Alternaria alternata – the main causal agent of disease symptoms in juniper, rose, yew and highbush blueberry in nurseries in southern Poland

MANAGEMENT OF PARTHENIUM WEED USING METABOLITES OF Alternaria japonica

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