Secondary Laparoscopic Cytoreduction in Recurrent Ovarian Cancer: A Large, Single-Institution Experience

Gallotta, Valerio; Conte, Carmine; Giudice, Maria Teresa; Nero, Camilla; Vizzielli, Giuseppe; Alletti, Salvatore Gueli; Cianci, Stefano; Lodoli, Claudio; Giorgio, Andrea Di; Rose, Agostino Maria De; Fagotti, Anna; Scambia, Giovanni; Ferrandina, Gabriella

doi:10.1016/j.jmig.2017.10.024

Cited by 53 publications

(35 citation statements)

References 30 publications

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“…The rate of complete debulking was 96.2% and the median DFS was 14.0 months ( 25 ). A study of analyzing the safety of laparoscopic secondary cytoreductive surgery in 58 patients with platinum-sensitive recurrent ovarian cancer showed that the median PFS was 28.0 months and the 2 year OS was 90.7% ( 26 ). Wang et al found that the OS of ovarian cancer patients with liver metastases who received R0 liver resection and cytoreductive surgery were 50.1 months, however, the OS of patients who received R0 cytoreductive surgery and non-R0 liver resection was 20.0 months ( 27 ).…”

Section: Discussionmentioning

confidence: 99%

A Population-Based Study on Liver Metastases in Women With Newly Diagnosed Ovarian Cancer

Zhao

et al. 2020

Front. Oncol.

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The purpose of this study was to analyze the incidence, clinical characteristics, prognostic factors and survival of ovarian cancer patients with liver metastases upon initial diagnosis. Methods: Patients with ovarian cancer liver metastases upon initial diagnosis between 2010 and 2016 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. Univariate and multivariate logistic regression was performed to identify the predictors of the presence of liver metastases in newly diagnosed ovarian cancer patients. Overall survival (OS) was assessed using the Kaplan-Meier method and logrank test. Univariate and multivariate Cox regression was conducted to determine the independent prognostic factors for OS. Results: A total of 1,744 ovarian cancer patients with liver metastases was identified from the SEER database, accounting for 6.7% of the entire ovarian cancer patients. As to the unique distant organ provided by SEER, liver was the most common metastatic site of ovarian cancer (4.65%). Age, race, laterality, histology, pathological grade, extrahepatic sites, stage of tumor were the predictors of the presence with liver metastases revealed by multivariable logistic regression model. Median OS for the patients with liver metastases at initial diagnosis of ovarian cancer was 16.0 months. Multivariate Cox regression model confirmed race, histology, extrahepatic metastatic sites, surgery and marital status were independent prognostic factors for OS. Conclusion: The study provided population-based estimates of the incidence and prognosis of newly diagnosed ovary cancer patients with liver metastases, which could be potentially used for the risk assessment and individualized treatment.

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Section: Discussionmentioning

confidence: 99%

A Population-Based Study on Liver Metastases in Women With Newly Diagnosed Ovarian Cancer

Zhao

et al. 2020

Front. Oncol.

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“…Consequently, cytoreductive surgery with HIPEC is currently recognized as the standard of care for managing peritoneal carcinomatosis secondary to colorectal or gynecological cancers in selected patients. 8,21,22…”

Section: Discussionmentioning

confidence: 99%

Physiologic and hemodynamic changes in patients undergoing open abdominal cytoreductive surgery with hyperthermic intraperitoneal chemotherapy

et al. 2021

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Objective We aimed to determine the physiological and hemodynamic changes in patients who were undergoing hyperthermic intraperitoneal chemotherapy (HIPEC) cytoreductive surgeries. Methods This prospective, observational study enrolled 21 patients who were undergoing elective cytoreductive surgery with HIPEC at our hospital over 2 years. We collected vital signs, hemodynamic parameters including global end-diastolic volume index (GEVI) and extravascular lung water index (ELWI) using the VolumeView™ system, and arterial blood gas analysis from all patients. Data were recorded before skin incision (T1); 30 minutes before HIPEC initiation (T2); 30 (T3), 60 (T4), and 90 (T5) minutes after HIPEC initiation; 30 minutes after HIPEC completion (T6); and 10 minutes before surgery completion (T7). Results Patients showed an increase in body temperature and cardiac index and a decrease in the systemic vascular resistance index. GEDI was 715.4 (T1) to 809.7 (T6), and ELWI was 6.9 (T1) to 7.3 (T5). Conclusions HIPEC increased patients’ body temperature and cardiac output and decreased systemic vascular resistance. Although parameters that were extracted from the VolumeView™ system were within their normal ranges, transpulmonary thermodilution approach is helpful in intraoperative hemodynamic management during open abdominal cytoreductive surgery with HIPEC. Trial registry name: ClinicalTrials.gov Trial registration number: NCT02325648 URL: https://clinicaltrials.gov/ct2/results?cond=NCT02325648&term

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“…1 Besides, the feasibility and safety of laparoscopic secondary cytoreductive surgery in patients with recurrent ovarian cancer were demonstrated by the same research team in another retrospective study. 2 Robot-assisted laparoscopy has overcome some difficulties associated with conventional laparoscopy since its approval by the US Food and Drug Administration. Robot-assisted laparoscopy has altered the landscape of minimally invasive gynecologic surgery.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

<p>The Pathogenesis and Prevention of Port-Site Metastasis in Gynecologic Oncology</p>

Gao¹,

Guo²,

Wang³

2020

CMAR

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Port-site metastasis (PSM) is a specific and challenging complication of laparoscopic gynecologic oncologic procedures. Research has demonstrated that PSM is associated with significant morbidity and poor outcome. The exact pathogenesis of PSM in gynecologic patients is not clear. Several preventive measures of PSM have been addressed in the relevant literature, and novel approaches to prevent this uncommon complication keep emerging. In this review, we summarized the potential mechanisms of PSM and discuss the controversies and merits of proposed preventive measures of PSM in gynecologic oncology. We undertook a literature search using the Medline database to identify studies on the pathogenesis and prevention of laparoscopic PSM. Hypotheses of PSM pathogeneses center on the immune response, pneumoperitoneum, wound contamination, and surgical method. Cogent evidence of effective prevention of PSM after laparoscopic surgery is lacking. Traditional preventive actions such as irrigation and tumor manipulation should be taken individually. Insufflation of hyperthermic CO 2 and humidified CO 2 leads to a better outcome in patients with a malignant tumor who undergo a laparoscopic procedure compared with normal CO 2 pneumoperitoneum. Port-site resection shows no advantage in survival and results in more wound events. PSM prevention plays a crucial part in the overall care of patients with gynecologic malignancies who undergo laparoscopic procedures.

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Secondary Laparoscopic Cytoreduction in Recurrent Ovarian Cancer: A Large, Single-Institution Experience

Cited by 53 publications

References 30 publications

A Population-Based Study on Liver Metastases in Women With Newly Diagnosed Ovarian Cancer

A Population-Based Study on Liver Metastases in Women With Newly Diagnosed Ovarian Cancer

Physiologic and hemodynamic changes in patients undergoing open abdominal cytoreductive surgery with hyperthermic intraperitoneal chemotherapy

<p>The Pathogenesis and Prevention of Port-Site Metastasis in Gynecologic Oncology</p>

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