Secondary Hyperparathyroidism in the Elderly: Means to Defining Hypovitaminosis D

McKenna, Malachi J.; Freaney, R.

doi:10.1007/pl00022725

Cited by 223 publications

(146 citation statements)

References 34 publications

(64 reference statements)

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“…However, other authors have proposed lower and higher levels as cutoff values: 12-16 ng/ ml (Ooms et al, 1995;Gloth et al, 1995;Thomas et al, 1998) and 44 ng/ml, respectively . This last value is very similar to the level proposed as being desirable to diminish fracture risk (Chapuy et al, 1992;Mc Kenna & Freaney, 1998).…”

Section: Discussionsupporting

confidence: 76%

“…In the present study the 'cutoff' 25OHD value, above which serum mmPTH levels remained stable and relatively low, was found to be 27 ng/ml. This value is close to 30 ng/ml, which is in the range of hypovitaminosis according to Mc Kenna and Freaney's (1998) definition of different vitamin D status. This 'cut-off' value is similar to that proposed by Haden et al (1999): 25 ng/ml, Melin et al (1999): 30 ng/ml and Chapuy et al (1997): 31 ng/ml, and is similar to the cutoff level associated with an increase in bone markers (Need et al, 2002).…”

Section: Discussionsupporting

confidence: 63%

“…The threshold of serum 25OHD that separates vitamin D sufficiency from insufficiency is generally defined by its biological effect, primarily by the increase in serum parathormone. A new category of desirable levels has been introduced, based on the 25OHD levels required to diminish hip fractures (Chapuy et al, 1992;Mc Kenna & Freaney, 1998). Reports in the literature have established serum 25OHD levels below which PTH begins to increase to be between 12 and 20 ng/ml (Bouillon et al, 1987;Gloth et al, 1995;Ooms et al, 1995;Mc Kenna & Freaney, 1998).…”

Section: Introductionmentioning

confidence: 99%

“…A new category of desirable levels has been introduced, based on the 25OHD levels required to diminish hip fractures (Chapuy et al, 1992;Mc Kenna & Freaney, 1998). Reports in the literature have established serum 25OHD levels below which PTH begins to increase to be between 12 and 20 ng/ml (Bouillon et al, 1987;Gloth et al, 1995;Ooms et al, 1995;Mc Kenna & Freaney, 1998). More recently, higher levels of 25OHD have been proposed as limits of insufficiency: 25,31 or 44 ng/ml (Chapuy et al, 1997;Haden et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

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High prevalence of vitamin D insufficiency in healthy elderly people living at home in Argentina

et al. 2004

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Objective: To evaluate the nutritional status of vitamin D in urban populations of healthy elderly people living at home, in different regions of Argentina. Design: Cross-sectional study. Subjects: In total, 386 ambulatory subjects over 65 y of age from seven cities (between latitude 261S and 551S) were asked to participate between the end of winter and the beginning of spring. Of these, 369 accepted, 30 were excluded because of medical history or abnormal biochemical determinations. Finally, 339 subjects (226 women and 113 men) (X7s.d.) (71.37 5.2 y) were included. Results: Serum 25OHD levels were lowest in the South (latitude range: 411S-551S): 14.275.6 ng/ml (Po0.0001vs North and Mid regions); highest in the North (261S-271S): 20.777.4 ng/ml (Po0.03 vs Mid, Po0.0001vs South); and intermediate in the Mid region (331S-341S) 17.978.2 ng/ml. Serum mid-molecule PTH (mmPTH) and 25OHD were inversely related: (r ¼ À0.24, Po0.001). A cutoff level of 25OHD at which serum mmPTH levels began to increase was established at 27 ng/ml. A high prevalence (87-52%) of subjects with 25OHD levels in the deficiency-insufficiency range (25OHD levels o20 ng/ml) was detected. Conclusion: This study shows that vitamin D deficiency/insufficiency in the elderly is a worldwide problem. Correction of this deficit would have a positive impact on bone health of elderly people. Sponsorship: Asociació n Argentina de Osteología y Metabolismo Mineral (AAOMM).

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Section: Discussionsupporting

confidence: 76%

Section: Discussionsupporting

confidence: 63%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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High prevalence of vitamin D insufficiency in healthy elderly people living at home in Argentina

et al. 2004

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“…Since vitamin D deficiency tends to decrease calcium level in blood with consequent secondary hyperparathyroidism, the measurement of intact parathyroid hormone (PTH) in serum has proven to be a valuable indicator of vitamin D status that can give additional information concerning the degree of compensatory changes. The level of serum 25(OH)D above which no further alteration in serum PTH occurs has to be defined but could define optimal levels of 25(OH)D (McKenna & Freaney, 1998).…”

Section: Vitamin Dmentioning

confidence: 99%

The use of biomarkers in multicentric studies with particular consideration of iodine, sodium, iron, folate and vitamin D

Ovesen

Boeing

2002

Eur J Clin Nutr

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Objective: To determine which biomarkers should be used in a European monitoring system to assess intake of iodine, sodium, iron, folate and vitamin D. These nutrients are relevant for human health but difficult to assess in the diet in a comparable way among countries. Results: Iodine and sodium are mainly excreted in urine. Mean population intakes of iodine and sodium can be estimated by casual urine samples. However, habitual individual intake assessments require multiple 24 h urine collections. Serum ferritin is a sensitive test of iron status (mobilizable storage iron) and continues to be the leading single determination for individual iron status, but with serum transferrin receptor as a promising alternative because it is more specific than ferritin. Erythrocyte folate and homocysteine in blood are markers of folate status which are able to discriminate between normal status and levels of insufficiency in an individual. Serum 25-hydroxyvitamin D is a good marker for vitamin D deficiency in the individual, and can distinguish between overt deficiency and marginal deficiency, especially if combined with serum parathyroid hormone. Conclusions: Specific and sensitive markers for the dietary intake of iodine, sodium, iron, folate and vitamin D are available, which have the advantage of being more accurate than intake estimations derived from dietary surveys. However, the use of biomarkers also has disadvantages such as extra burden in terms of logistics, budget and ethical approval, and can moreover reduce the participation rate. More basic data for the validity of cross-country comparisons are needed and ideas in terms of study design and sampling frame.

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The Effect of Narrowband UV-B Treatment for Psoriasis on Vitamin D Status During Wintertime in Ireland

Ryan¹,

Moran²,

McKenna³

et al. 2010

Arch Dermatol

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Secondary Hyperparathyroidism in the Elderly: Means to Defining Hypovitaminosis D

Cited by 223 publications

References 34 publications

High prevalence of vitamin D insufficiency in healthy elderly people living at home in Argentina

High prevalence of vitamin D insufficiency in healthy elderly people living at home in Argentina

The use of biomarkers in multicentric studies with particular consideration of iodine, sodium, iron, folate and vitamin D

The Effect of Narrowband UV-B Treatment for Psoriasis on Vitamin D Status During Wintertime in Ireland

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