High prevalence of vitamin D insufficiency in healthy elderly people living at home in Argentina

Oliveri, Beatriz; Plantalech, L.; Bagur, A.; Wittich, A.; Rovai, G; Pusiol, Eduardo; Giovanelli, J López; Ponce, Graciela; Nieva, Adriana; Chaperón, A; Ladizesky, M.; Somoza, J.; Casco, C.; Zeni, Susana Noemí; Parisi, Muriel S.; Mautalén, C.

doi:10.1038/sj.ejcn.1601786

Cited by 78 publications

(63 citation statements)

References 30 publications

(44 reference statements)

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“…Asian migrants that moved to northern countries and Canadian summer holiday takers that travelled closer to equatorial latitudes showed a decrease and increase in their vitamin D levels respectively, confirming this relationship [17][18][19]128]. Furthermore, in Argentina, vitamin D deficiency is significantly lower in populations living in northern regions where mean latitude, temperature, and heliophany (daily hours of solar irradiation) varied from 48°S to 27°S, 3.7°C to 16.1°C, and 3.6 h to 6.3 h of UV irradiation, respectively [78]. The findings from China, although in different population groups, also indicate much lower 25(OH)D levels in northern latitudes [42,45].…”

Section: Latitude and Seasonsupporting

confidence: 62%

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Global vitamin D status and determinants of hypovitaminosis D

Wahl²,

et al. 2009

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Section: Latitude and Seasonsupporting

confidence: 62%

“…This study showed a cut-off level of 25(OH)D of 68 nmol/L at which serum PTH began to increase [78]. Another study in ambulatory women from Buenos Aires showed differences in 25(OH)D levels in summer (63 nmol/L) and winter (53 nmol/L) [79].…”

Section: Latin Americamentioning

confidence: 98%

Global vitamin D status and determinants of hypovitaminosis D

Wahl²,

et al. 2009

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“…The frequency of vitamin D insufficiency observed in our study is considerably higher than that reported by Fradinger et al [19] who found that 46.4% of patients from a sample of 198 postmenopausal women of similar average age to the patients in this study, living in the city of Buenos Aires (Latitude: 34˚S) had less than 30 ng/ml. The average value of 25(OH)D observed in our sample (22.4 ± 8.6 ng/ml) is similar to that found by Oliveri et al [13] in another study carried out in 364 volunteers from different regions of Argentina. However, the mean age of our patients was lower than that cited by this group.…”

Section: Discussionsupporting

confidence: 77%

“…Prevalence of hypovitaminosis D has been studied in a sample of 339 healthy adults from different regions of Argentina. The mean serum 25(OH)D was lower in the South (14.2 ± 5.6 ng/ml) compared to that in the Northern and Central regions (20.7 ± 7.4 ng/ml, and 17.9 ± 8.2 ng/ml, respectively) [13].…”

Section: Introductionmentioning

confidence: 99%

Hypovitaminosis D and Associated Risk Factors in Postmenopausal Women

Masoni¹,

Menoyo²,

Bocanera³

et al. 2014

Health

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Given the relevance of vitamin D in calcium metabolism homeostatic control, as well as its role as differentiation and cell proliferation modulator, it is important to study its circulating level in patients considered at risk, in order to develop prevention strategies. We studied 77 postmenopausal women with no history of osteoactive drug therapy, corticosteroid intake or diseases that could alter bone metabolism, attending the Menopause Center at the Hospital Provincial del Centenario, Rosario, Argentina. A medical history was taken, and a food consumption frequency questionnaire was applied in order to estimate daily calcium intake. To assess daily physical exercise, work and sports activities were investigated. Serum parathyroid hormone (PTH) and 25(OH)D were measured, and a hip DXA scan was performed in every patient. An inappropriate level of 25(OH)D was observed in 86.3% of patients. The 25(OH)D average value was found within the insufficiency range (<30 ng/ml) whereas PTH average concentration fell within the normal range, and bone mineral density average value was found within the osteopenic category. A statistically significant negative logarithmic association was observed between serum PTH level and vitamin D status (p = 0.01). Mean 25(OH)D concentration among patients who had reported fractures was significantly lower than the corresponding to women who had not suffered this type of event. Patients with vitamin D deficiency had significantly wider mean Cobb angle; higher sum of wedge angles of T4 -T12 vertebral bodies mean values, and higher uncompromised vertebrae wedge angle values than non-deficient women. This study shows high hypovitaminosis D occurrence among these postmenopausal women.

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“…25-Hydroxyvitamin D insufficiency has been commonly described in the institutionalized older population of the northern hemisphere, but it has recently been proposed that insufficiency may indeed be more common in the general population than previously thought (Chapuy et al, 1996(Chapuy et al, , 1997bJacques et al, 1997;Bettica et al, 1999;Aguado et al, 2000;Inderjeeth et al, 2000;Oliveri et al, 2004). Combination calcium and vitamin D are commonly given for the treatment of osteoporosis.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D insufficiency in older female community-dwelling acute hospital admissions and the response to supplementation

et al. 2006

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Objectives: A significant proportion of the older population may exhibit vitamin D insufficiency. We sought to establish the proportion of 25-hydroxyvitamin D (25OHD) insufficient individuals in an older female cohort presenting for acute medical admission and how they responded to supplementation. Design: A prospective cohort study. Setting: Hospital admissions followed up as a population-based study. Subjects: A total of 114 consecutive female acute medical admissions aged over 65 years from November 2003 to January 2004 were enrolled. All admissions with hypercalcaemia, metabolic bone disease (other than osteoporosis/osteomalacia) and creatinine 4150 mmol/l were excluded. Interventions: iPTH, calcium and 25OHD levels were measured in each patient. Of the total, 22 were already receiving calcium and vitamin D supplementation at enrolment. The remaining 92 were commenced on 800 IU of vitamin D and 1 g calcium, and levels were reassessed after supplementation for 3 months. Results: 25-Hydroxyvitamin D insufficiency, as defined by a 25OHD concentration of o50 nmol/l, was present in 86 (75.4%) patients at initial assessment (mean 35.8 nmol/l, s.d. 23.3). Secondary hyperparathyroidism was present in only 36.7% of those with 25OHD deficiency at baseline. Of the total, 51 (44.7%) patients presented for follow-up. 25-Hydroxyvitamin D concentration increased in this group from 42.1 nmol/l (s.d. 26.6) to 59.5 nmol/l (s.d. 27.4) after supplementation, Po0.001, but 18(35.3%) still remained deficient. There was no significant change in iPTH or calcium following supplementation. Assessment of compliance revealed 6 (11.7%) admitted to partial or non-compliance. Conclusions: Insufficiency of 25OHD was very common in this cohort. Despite calcium and vitamin D supplementation, 25OHD concentrations failed to reach normality in a significant proportion. Maintaining vitamin D and calcium intake at the level of current recommended doses may not be sufficient to ensure adequate 25OHD stores.

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High prevalence of vitamin D insufficiency in healthy elderly people living at home in Argentina

Cited by 78 publications

References 30 publications

Global vitamin D status and determinants of hypovitaminosis D

Global vitamin D status and determinants of hypovitaminosis D

Hypovitaminosis D and Associated Risk Factors in Postmenopausal Women

Vitamin D insufficiency in older female community-dwelling acute hospital admissions and the response to supplementation

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