Secondary hip dysplasia increases risk for early coxarthritis after Legg-Calve-Perthes disease. A study of 255 hips

Moličnik, Andrej; Janša, Jošt; Kocjančič, Boštjan; Kralj‐Iglič, Veronika; Dolinar, Drago

doi:10.1080/10255842.2019.1634193

Cited by 4 publications

(5 citation statements)

References 17 publications

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“…Intra-or extra-articular instability of the joint Usually consequences of poor care and/or injuries causing damage to the hip joint, e.g. inflammation of surrounding tendons, some diseases (Legg-Calvé-Perthes Disease), acetabular labrum lesions or abnormalities [37][38][39].…”

Section: Presence Of Different Malformationsmentioning

confidence: 99%

Developmental Dysplasia of the Hip: A Review of Etiopathogenesis, Risk Factors, and Genetic Aspects

Harsanyi¹,

Zamborský²,

Krajčíová³

et al. 2020

Medicina

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As one of the most frequent skeletal anomalies, developmental dysplasia of the hip (DDH) is characterized by a considerable range of pathology, from minor laxity of ligaments in the hip joint to complete luxation. Multifactorial etiology, of which the candidate genes have been studied the most, poses a challenge in understanding this disorder. Candidate gene association studies (CGASs) along with genome-wide association studies (GWASs) and genome-wide linkage analyses (GWLAs) have found numerous genes and loci with susceptible DDH association. Studies put major importance on candidate genes associated with the formation of connective tissue (COL1A1), osteogenesis (PAPPA2, GDF5), chondrogenesis (UQCC1, ASPN) and cell growth, proliferation and differentiation (TGFB1). Recent studies show that epigenetic factors, such as DNA methylation affect gene expression and therefore could play an important role in DDH pathogenesis. This paper reviews all existing risk factors affecting DDH incidence, along with candidate genes associated with genetic or epigenetic etiology of DDH in various studies.

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Section: Presence Of Different Malformationsmentioning

confidence: 99%

Developmental Dysplasia of the Hip: A Review of Etiopathogenesis, Risk Factors, and Genetic Aspects

Harsanyi¹,

Zamborský²,

Krajčíová³

et al. 2020

Medicina

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“…Furthermore, alternative surgical interventions, such as percutaneous transepiphyseal drilling of the femoral head combined with closure of the greater trochanter apophysis, can be an attractive option during early stages of fragmentation (Stulberg type 1–2) as this does not compromise any potential future treatment options [ 17 ]. Similarly, a recent study by Moličnik et al found that biomechanical changes caused by deformed hip articulation play a critical role in the development of secondary hip arthritis in patients with Legg Calve Perthes disease [ 18 ]. The authors found a significant association between the radiological hip containment parameter (small center-edge angle) and an unfavorable distribution of stresses across the hip articulation.…”

Section: Discussionmentioning

confidence: 99%

Rate of Total Hip Replacement after Legg Calve Perthes Disease in a Canadian Province

Tan,

Sharma,

Bansal

et al. 2023

Pediatric Reports

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Legg Calve Perthes disease is a pediatric hip condition that leads to early hip degeneration. The efficacy of operative and nonoperative treatment is not well defined in the literature. Using the rate of total hip arthroplasty as a surrogate measure for symptomatic hip degeneration, the rate of total hip arthroplasty was compared in Legg Calve Perthes disease patients with and without previous surgical intervention in the province of Manitoba, Canada. A retrospective review was conducted using de-identified, individual-level administrative records of health services for the entire population of Manitoba. Codes for Legg Calve Perthes disease, femoral osteotomies, pelvic osteotomies, adductor tenotomies, and total hip arthroplasty were searched from 1984 to 2018. The rate of total hip arthroplasty in patients with Legg Calve Perthes disease was determined for two groups: (1) patients with earlier surgical intervention and (2) patients with no previous surgical intervention. Of the 202 patients included in the study, 180 had no prior surgery and 22 had prior surgery. The rate of total hip arthroplasty between the previous operative and nonoperative groups was found to be 32% and 40%, respectively (p = 0.458). There was no significant difference in rates of total hip arthroplasty in the operative and nonoperative groups. Further prospective studies are required to elucidate the differences in outcomes between operative and nonoperative treatment groups in patients with Legg Calve Perthes disease.

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“…L egg-Calve-Perthes disease (LCPD) and acetabular dysplasia commonly present together and are associated with other hip disorders, including osteochondritis dissecans (OCD) and femoroacetabular impingement (FAI) [1][2][3][4] . The classic OCD definition is an idiopathic, focal disruption of articular cartilage and subchondral bone 4 .…”

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confidence: 99%

Arthroscopic Femoral Head Allograft With Proximal Femoral/Periacetabular Osteotomies for Sequelae of Perthes

Girardi,

Kraeutler,

Lee

et al. 2024

JBJS Case Connector

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Case: We describe the unique case of a 20-year-old man with a history of Legg-Calve-Perthes disease, hip dysplasia, and osteochondral fragmentation of the medial femoral head. We performed arthroscopic femoroplasty and femoral head allografting, followed by a valgus-producing derotational femoral osteotomy (DFO) and periacetabular osteotomy (PAO). At 1-year follow-up, the patient achieved osseous union and complete femoral head healing with return to his active hobbies. Conclusion: We describe the successful utilization of arthroscopic allografting for medial femoral head osteochondral fragmentation. To our knowledge, this is the first report on femoral head arthroscopic allografting before DFO and PAO.

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Secondary hip dysplasia increases risk for early coxarthritis after Legg-Calve-Perthes disease. A study of 255 hips

Cited by 4 publications

References 17 publications

Developmental Dysplasia of the Hip: A Review of Etiopathogenesis, Risk Factors, and Genetic Aspects

Developmental Dysplasia of the Hip: A Review of Etiopathogenesis, Risk Factors, and Genetic Aspects

Rate of Total Hip Replacement after Legg Calve Perthes Disease in a Canadian Province

Arthroscopic Femoral Head Allograft With Proximal Femoral/Periacetabular Osteotomies for Sequelae of Perthes

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