Secondary-electron-bremsstrahlung imaging for proton therapy

Yamaguchi, Mitsutaka; Nagao, Yuto; Ando, K.; Yamamoto, Seiichi; Toshito, T.; Kataoka, J.; Kawachi, Naoki

doi:10.1016/j.nima.2016.07.034

Cited by 40 publications

(52 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, complexities associated with the coupling between acoustic sensors and human skin exist, rendering this technique laborious. In addition to the abovementioned methods, secondary electron bremsstrahlung can be used for proton range verification [ 10 , 11 ], which uses bremsstrahlung photons generated via charge particle deceleration in matter. Because these photons are of low energy, the method is only applicable to the irradiation monitoring of superficial tumors (i.e., shallow depths).…”

Section: Introductionmentioning

confidence: 99%

Proton range monitoring using 13N peak for proton therapy applications

Islam

Beni

et al. 2022

PLoS ONE

View full text Add to dashboard Cite

The Monte Carlo method is employed in this study to simulate the proton irradiation of a water-gel phantom. Positron-emitting radionuclides such as 11C, 15O, and 13N are scored using the Particle and Heavy Ion Transport Code System Monte Carlo code package. Previously, it was reported that as a result of 16O(p,2p2n)13N nuclear reaction, whose threshold energy is relatively low (5.660 MeV), a 13N peak is formed near the actual Bragg peak. Considering the generated 13N peak, we obtain offset distance values between the 13N peak and the actual Bragg peak for various incident proton energies ranging from 45 to 250 MeV, with an energy interval of 5 MeV. The offset distances fluctuate between 1.0 and 2.0 mm. For example, the offset distances between the 13N peak and the Bragg peak are 2.0, 2.0, and 1.0 mm for incident proton energies of 80, 160, and 240 MeV, respectively. These slight fluctuations for different incident proton energies are due to the relatively stable energy-dependent cross-section data for the 16O(p,2p2n)13N nuclear reaction. Hence, we develop an open-source computer program that performs linear and non-linear interpolations of offset distance data against the incident proton energy, which further reduces the energy interval from 5 to 0.1 MeV. In addition, we perform spectral analysis to reconstruct the 13N Bragg peak, and the results are consistent with those predicted from Monte Carlo computations. Hence, the results are used to generate three-dimensional scatter plots of the 13N radionuclide distribution in the modeled phantom. The obtained results and the developed methodologies will facilitate future investigations into proton range monitoring for therapeutic applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Proton range monitoring using 13N peak for proton therapy applications

Islam

Beni

et al. 2022

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…There are different approaches to ion beam therapy monitoring currently under development. Most of them are based on the idea of exploiting by-products of patient irradiation with proton beam: prompt gamma radiation, which is the main focus of this chapter, but also acoustic wave [10; 11], secondary protons during carbon therapy [12], secondary electron bremsstrahlung [13], neutrons [14] and β + -emitters [15]. For the latter, the range verification consists in imaging the decay of the β + -emitters in two photons, by means of a Positron Emission Tomography (PET) device.…”

Section: Introductionmentioning

confidence: 99%

Range Verification by Means of Prompt-Gamma Detection in Particle Therapy 1

Wrońska¹,

Dauvergne²

2021

Radiation Detection Systems

View full text Add to dashboard Cite

Ion range verification in particle therapy, possibly in real time, is still an open issue to improve the treatment quality by reducing safety margins. Among the various methods that are under study or already brought to the clinics, prompt gamma offer a unique opportunity of real time control. In this chapter, we present the physical background and conditions specific for the operation environment in the clinics, followed by an overview of the various techniques relying on prompt-gamma detection that have been proposed and developed for more than a decade. Different approaches, based on imaging and non-imaging techniques, providing either integrated or differential information are described, and their maturity, limitations and clinical usefulness are discussed.

show abstract

“…Nevertheless, this method does not give information from the irradiated medium. Noninvasive methods using radiations emitted from the irradiated medium were developed in the context of hadrontherapy to monitor the beam range, such as prompt gamma measurements [16][17][18], PET acquisitions [19], and bremsstrahlung radiation measurements [20][21][22][23]. This work presents a noninvasive beam monitoring method based on the detection of the bremsstrahlung X-rays, emitted by the irradiated medium, to monitor the ion beam for the radiobiology experiments.…”

Section: Introductionmentioning

confidence: 99%