Secondary Cutaneous Plasmacytoma

Cavo, Michèle; Gobbi, Marco; Ghetti, P; Patrizi, Annalisa; Pileri, Stefano; Varotti, C

doi:10.1159/000206907

Cited by 9 publications

(2 citation statements)

References 6 publications

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“…Moreover, most patients have extensive tumor burden, and this should be considered a sign of poor prognosis. Despite the fact that some patients have survived for several years after developing cutaneous involvement by MM, 8,10,31,34,36,43 on average, death of most patients occurred within 12 months after the diagnosis. At autopsy, most patients have extensive plasmacytic infiltration of multiple organs.…”

Section: Commentmentioning

confidence: 99%

Cutaneous Involvement in Multiple Myeloma

Requena¹,

Kutzner²,

Palmedo³

et al. 2003

Arch Dermatol

112

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Background: Specific cutaneous involvement in patients with multiple myeloma (MM) is very uncommon. It usually occurs in late stages of MM as a reflection of increased tumor cell burden. We studied 8 patients with cutaneous involvement of MM without underlying bony lesions and reviewed the literature on this rare dermatologic manifestation.Design: We were particularly interested in the clinical course of patients with MM and cutaneous metastases, including survival once metastases were detected and the possible influence of various forms of therapy. Our goal was also to identify the immunoglobulin and the lightchain type in these cases, with emphasis on any possible association between a particular immunoglobulin class and cutaneous involvement, as well as the histopathologic, immunohistochemical, and cytogenetic features of the neoplastic plasma cells involving the skin.Setting: University department of dermatology, university hospital, and private practice.Patients: Medical records and biopsy specimens from 8 patients with MM and specific cutaneous lesions were reviewed.Results: Cutaneous lesions consisted of multiple erythematous or violaceous nodules or plaques with a wide anatomical distribution. Histopathologically, 2 different patterns were identified: nodular and diffuse interstitial.

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Section: Commentmentioning

confidence: 99%

Cutaneous Involvement in Multiple Myeloma

Requena¹,

Kutzner²,

Palmedo³

et al. 2003

Arch Dermatol

112

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“…Cutaneous plasmacytomas usually represent dissemination of end-stage MM. Some cutaneous plasmacytomas may develop from the direct expansion of underlying myelomatous bone lesions or as a part of plasma cell leukemia [4, 5, 6]. This patient did not manifest BM plasmacytosis nor any plasma cell leukemic changes, suggesting that the initial MM plasma cells had transformed into subcutaneous plasmacytomas after chemotherapy.…”

Section: Discussionmentioning

confidence: 95%

IgD Multiple Myeloma Preceding the Development of Extensive Extramedullary Disease without Medullary Involvement

Iwasaki

Hamano²,

Ogata³

et al. 2000

Acta Haematol

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We present a unique case of IgD multiple myeloma (MM) preceding the development of extensive extramedullary disease without medullary involvement. A 63-year-old man was diagnosed with IgD-λ MM when he developed anemia. After 3 months of chemotherapy, he was in complete remission as evidenced by the disappearence of bone marrow (BM) plasmacytosis, monoclonal IgD protein in his serum, and Bence Jones proteinuria. Six months after diagnosis, his disease took an unusual course with the development of plasmacytomas in the skin, without medullary involvement. He then received chemotherapy, resulting in the complete disappearance of the subcutaneous plasmacytomas. Two years after the initial diagnosis, his disease took an aggressive clinical course with retroperitoneal relapse, leading to the patient’s death within 1 month. The two separate episodes of extramedullary disease were associated with elevated serum lactic dehydrogenase levels and the absence of plasma cells in the BM. This case provides evidence of two separate transformations of the original malignant MM clone.

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