Secondary aneurysmal bone cyst in Langerhans cell histiocytosis: Case report, literature review

Lomoro, Pascal; Simonetti, Igino; Vinci, Giorgia; Fichera, V.; Tarotto, Luca; Trovato, Piero; Gorone, Maria Sole Prevedoni

doi:10.1016/j.ejro.2019.02.002

Cited by 14 publications

(13 citation statements)

References 16 publications

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“…Another differential diagnosis to consider is other giant cell lesions central giant‐cell granuloma (CGCG), peripheral giant‐cell granuloma (PGCG), Langerhans cell histiocytosis, and initial stages of cherubism. 5 , 11 , 12 , 13 , 14 As the management of these conditions is different, it is important to distinguish between them. Laboratory results differ between the different types of HPT.…”

Section: Discussionmentioning

confidence: 99%

Hyperparathyroidism: Unusual location of brown tumors

Fazaa

Yasmine

Miladi

et al. 2022

Clinical Case Reports

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Section: Discussionmentioning

confidence: 99%

Hyperparathyroidism: Unusual location of brown tumors

Fazaa

Yasmine

Miladi

et al. 2022

Clinical Case Reports

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“…Although this finding occasionally makes it difficult to differentiate LCH from aneurysmal bone cysts and cephalohematomas, perilesional bone marrow edema and enhancement can serve as clues for differentiating LCH from these differential diagnoses. Additionally, LCH lesions with FFLs are mainly reported in the craniofacial bones rather than in the appendicular bones [ 23 , 24 ]. These FFLs represent hemorrhage, which can be caused by trauma or can develop spontaneously.…”

Section: Discussionmentioning

confidence: 99%

Clinical and magnetic resonance imaging feature differences between solitary and multiple type Langerhans cell histiocytosis involving the craniofacial bone

Matsushita

Shimono

Okuma

et al. 2022

Heliyon

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To investigate the clinical and contrast-enhanced magnetic resonance imaging (MRI) features of craniofacial bone Langerhans cell histiocytosis (LCH) and discuss the differences between a solitary lesion group (SLG) and multiple lesions group (MLG). Method: This study included 22 consecutive patients with pathologically proven LCH who underwent contrastenhanced MRI. The clinical data and MRI features were retrospectively assessed. Results: The mean patient age was 5 years, and 15 patients were male. The frontal bone was the most frequently affected bone. Ten and 12 patients were classified into the SLG and the MLG, respectively. The following MRI features were observed in >50% cases: T1WI hyperintensity in 15 (68%) cases, T2WI hyperintensity in 16 (73%) cases, bulging sign in 18 (82%) cases, concentric or eccentric soft tissue mass formation in 13 (59%) cases, soft tissue edema in 16 (73%) cases, any grade of bone marrow edema in 16 (73%) cases, surrounding bone enhancement in 17 (77%) cases, and surrounding soft tissue enhancement in 16 (73%) cases. Patient age was significantly higher in the SLG than that in the MLG (P ¼ 0.0014). Perilesional bone marrow edema and enhancement were significantly more prominent in the SLG than in the MLG (P ¼ 0.032, P ¼ 0.040). Conclusions: Contrast-enhanced MRI showed additional significant findings of mainly the surrounding details. Older age, extensive bone marrow edema, and enhancement may indicate solitary-type LCH rather than multipletype LCH. These differences may help distinguish between solitary-and multiple-type LCH, which have different treatment strategies.

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“…11 Since that time, the understanding of LCH has grown exponentially through reported case series, [12][13][14][15][16][17][18] including numerous descriptions of LCH presenting at soft tissue sites. 12,19,20 The disease is clinically heterogeneous and relatively uncommon. It is the most common of the dendritic cell neoplasms with an incidence of approximately 5 cases per 1 million population annually.…”

Section: Histiocytic Neoplasms Langerhans Cell Histiocytosismentioning

confidence: 99%

Nonlymphoid Hematopoietic Diseases Presenting in Bone, Soft Tissue, and Other Extranodal Sites

Cassidy

Rosenberg

Poveda

et al. 2021

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Although rare in everyday practice, the initial presentation of hematopoietic neoplasms other than lymphoma in the musculoskeletal system and other extranodal sites can generate challenging diagnostic problems for surgical pathologists. Objective.— To review the morphologic and immunophenotypic features of various nonlymphoid hematopoietic diseases presenting at extranodal sites, with emphasis on the inherent diagnostic pitfalls and differential diagnoses of these entities to aid surgical pathologists in their accurate recognition. Data Sources.— Cases reviewed herein represent both in-house and consult cases seen at our institution between 2010 and 2021. Conclusions.— Entities that present in this way include myeloid neoplasms and histiocytic/dendritic cell neoplasms. These tumors commonly cause nonspecific symptoms, and their histologic appearance can overlap with a variety of benign neoplasms and reactive processes. This can lead to delay in diagnosis and intervention with potentially lifesaving therapy; thus, accurate and expedient recognition is of paramount importance.

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Secondary aneurysmal bone cyst in Langerhans cell histiocytosis: Case report, literature review

Cited by 14 publications

References 16 publications

Hyperparathyroidism: Unusual location of brown tumors

Hyperparathyroidism: Unusual location of brown tumors

Clinical and magnetic resonance imaging feature differences between solitary and multiple type Langerhans cell histiocytosis involving the craniofacial bone

Nonlymphoid Hematopoietic Diseases Presenting in Bone, Soft Tissue, and Other Extranodal Sites

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