Secondary Anetoderma Overlying Pilomatrixomas

Fujioka, Masaki; Nishimura, Gozo; Miyazato, Osamu; Yamamoto, Tsuneyuki; Takehisa, Yosida

doi:10.1159/000073097

Cited by 24 publications

(21 citation statements)

References 7 publications

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“…İlk kez 1943 yılında tanımlanan ve tüm PM'lı olguların %2'sini oluşturan anetodermik form ise klinik olarak gevşek, sarkık veya kese benzeri bir lezyon şeklinde görülebileceği gibi, keloid veya hipertrofik sikatris benzeri ya da buruşuk ve oldukça katlantılı atrofik deriyle örtülü psödobüllöz görünümlü bir lezyon şeklinde de karşımıza çıkabilir. Anetodermik PM formunun histopatolojisinde lenfatik dilatasyon ve dermal ödem yanında anetodermik değişiklikler ile uyumlu olarak elastik liflerde azalma ve kollajen liflerde güçsüzleşme belirlendiği bildirilmiştir [13][14][15][16][17] . Bazı yazarlar tarafından büllöz görünüme yol açan bu iki klinik formun psödobüllöz veya lenfanjiektatik form olarak adlandırılan benzer antiteler olduğu ileri sürülmekle birlikte, büllöz PM'da histopatolojik olarak gerçek bir dermal bülün görülmesi ile PM'nın anetodermik değişiklik gösteren formundan ayırt edilebilmesinin mümkün olabileceği ileri sürülmüştür.…”

Section: Discussionunclassified

“…Sıklıkla baş, boyun ve üst ekstremitelerde yerleşen lezyonlar daha nadir olarak gövde ve alt ekstremitelerde de görülebilmektedir [1][2][3][4][5] . Çok nadir de olsa malin dönüşüm gösterebilen PM'nın klasik formuna ilaveten multipl, malin, perforan, büllöz ve anetodermik olmak üzere nadir görülen atipik PM formları da tanımlanmıştır [6][7][8][9][10][11][12][13][14][15][16][17] . Burada sağ kolundaki PM lezyonu üzerinde kalın duvarlı gevşek psödobüllöz görünüm izlenen ve histopatolojik olarak anetodermik özellikler saptanan 11 yaşında bir kız olgu sunulmaktadır.…”

Section: Introductionunclassified

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Psödobüllöz Anetodermik Pilomatrikoma

Akarsu¹,

İlknur²,

Kibar³

et al. 2013

Turkderm

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Türk derm-De ri Has ta lık la rı ve Fren gi Ar şi vi Der gi si, Ga le nos Ya yı ne vi ta ra f›n dan ba s›l m›fl t›r. Turk derm-Arc hi ves of the Tur kish Der ma to logy and Ve ne ro logy, pub lis hed by Ga le nos Pub lis hing. ÖzetPilomatrikoma (PM) kıl matriksi ve kıl şaftının primitif hücrelerinden köken alan; çoğunlukla baş, boyun ve üst ekstremitelerde görülen asemptomatik, yavaş büyüyen, benin bir deri tümörüdür. Tipik lezyon genellikle soliter, sert kıvamlı, üzeri normal veya eritemli deri ile örtülü, büyüklükleri 0,5 ile 3 cm arasında değişen, derin yerleşimli dermal veya subkutanöz nodül ile karakterizedir. Nadir görülen atipik PM formları içinde yer alan büllöz ve anetodermik PM formlarında lezyonların üzerinde büllöz görüntü oluşabilmektedir. Burada sağ kolunda üzerinde kalın duvarlı gevşek büllöz görünüm izlenen anetodermik PM'lı 11 yaşında bir kız olgu sunulmaktadır. (Türk derm 2013; 47: 114-6) Anah tar Ke li me ler: Adneksiyal tümör, pilomatrikoma, büllöz görünüm, büllöz pilomatrikoma, anetodermik pilomatrikoma Sum maryPilomatricoma (PM) is an asymptomatic, slowly growing, benign skin tumour originating from primitive cells of the hair matrix and hair shaft and appears mostly on the head, neck, and the upper extremities. Typical lesion is usually characterized by a solitary, firm, deep-seated dermal or subcutaneous nodule, covered by normal or erythematous skin, and usually varying in size from 0.5 to 3 cm. Bullous appearance can occur on the lesions of bullous PM and anetodermic PM which are located in the rare atypical forms of PM. Here, we present an 11-year-old girl with an anetodermic PM on her right arm that showed thick-walled flaccid bullous formation over it. (Turkderm 2013; 47: 114-6)

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Section: Discussionunclassified

Section: Introductionunclassified

Psödobüllöz Anetodermik Pilomatrikoma

Akarsu¹,

İlknur²,

Kibar³

et al. 2013

Turkderm

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“…Clinical characteristics reported include semi-transparent, erythematous, bluish or skin-coloured, heavily folded or striae-like, flaccid blisters overlying a solitary, firm-to-hard nodule (2, 4). Mechanical irritations such as continuous mechanical stimulation, scratching and pinching trauma and continuous pressure play an important role in the development of bullous pilomatricomas (2,5).…”

Section: A Bullous Pilomatricoma Developed After Hepatitis a Vaccinationmentioning

confidence: 99%

“…It is supposed that this atrophic appearance is related to the loss of elastic fibres, and dermal oedema (1). In the aetiopathogenesis, it is suggested that the cause of the bullous appearence of the tumour is obstruction of lymphatics, and congestion by lymphatic fluid (1,2,5).…”

Section: Lettersmentioning

confidence: 99%

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A Bullous Pilomatricoma Developed after Hepatitis-A Vaccination

Taş

Sar

2015

West Indian Med J

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A Bullous Pilomatricoma Developed after Hepatitis A VaccinationThe Editor, Sir, Pilomatricomas originate from hair matrix cells and usually appear as firm, solitary and asymptomatic nodules beneath the skin. These tumours occur mostly in children. They are generally located on the face and neck (1). Bullous pilomatricoma is an uncommon lesion and only few cases of this variant have been reported in the literature (1, 2). We report a 7-year old girl with a pilomatricoma showing bullous appearance. The patient suffered from a dome shaped, bullous mass on the left arm. The 1.5 × 1.5 cm lesion presented one month previously and progressively enlarged. In the history of the patient, there was a hepatitis A vaccination to the same area with the bullous lesion, about four months earlier. Two days after the vaccination, severe inflammation occured in the same region. The patient did not have any family history of such or mechanical trauma. On dermatologic examination, a dome shaped, red-brown coloured, semi-translucent bullae was noted (Fig. 1A).The bullae collapsed inward with palpation and a firm, small, painless mass was felt at the bottom of the lesion. When the lesion was pressed with the tip of a pen, it had a wrinkledatrophic appearance (Fig. 1B). The other physical and systemic examination findings were normal and there was no lymphadenopathy. Routine haematological and biochemical examinations of the patient were within the normal limits. With dermatoscopy, red-coloured tortuous small vessels on an irregular white opacity, which settled on a livid-red background, were observed (Fig. 1C).Needle aspiration material of the bullae was haemorrhagic and its microbiological culture was sterile. With these findings, the diagnosis of the lesion was made as a "bullous pilomatricoma". The mass was totally removed with surgical excision. On histopathological examination, the tumour nests were composed of eosinophilic shadow cells, basophilic cells and surrounded by a fibrous capsule in the deep dermis. Calcium salt depositions were observed in the tumour mass. In the superficial dermis, marked lymphoedema and increased numbers of dilated lymphatics filled with eosinophilic lymph fluid were observed (Fig. 2). Bullous pilomatricoma is a very rare form of pilomatricoma (3). Their incidence is between 3% and 6% (1). Although pilomatricomas can be associated with other genetic disorders such as myotonic dystrophy and Gardner's syndrome, the bullous variant is not associated with these syndromes (2). The bullous lesions are located mostly in the shoulder and upper extremity and predominantly in females. They are usually asymptomatic lesions (1, 2). Clinical characteristics reported include semi-transparent, erythematous, bluish or skin-coloured, heavily folded or striae-like, flaccid blisters overlying a solitary, firm-to-hard nodule (2, 4). Mechanical irritations such as continuous mechanical stimulation, scratching and pinching trauma and continuous pressure play an important role in the development of bullous pilomatricomas ...

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Micro‐Raman spectroscopy used to identify and grade human skin pilomatrixoma

Cheng¹,

Liu²,

Liu³

et al. 2005

Microscopy Res & Technique

294

181

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Raman microspectroscopy was applied to analyze the changes in structural conformation and chemical composition of the mass of human skin pilomatrixoma (PMX). The normal skin dermis, collagen type I, and hydroxyapatite (HA) were used as control. The excised specimens from two patients diagnosed as a typical PMX were detected, in which one specimen was a soft mass, but the other was a hard mass with somewhat calcified deposits via histopathological examination. The Raman spectrum of normal skin dermis was found to be similar to the Raman spectrum of collagen type I, confirming that the collagen type I was a predominant component in normal skin dermis. The differences of Raman peak intensity between normal skin dermis and soft or hard PMX mass were obvious at 1,622-1,558, 1,400-1,230, 1,128, 1,000-850, 749, and 509 cm(-1). In particular, the peak at 1,665 cm(-1) assigned to amide I band shifted to 1,655 cm(-1) and the peak at 1,246 cm(-1) corresponding to amide III band was reduced in its intensity in hard PMX mass. The significant changes in collagen content and its structural conformation, the higher content of tryptophan, and disulfide formation in PMX masses were markedly evidenced. In addition, the shoulder and weak peak at 960 cm(-1) assigned to the stretching vibration of PO(4) (3-) of HA also appeared respectively in the Raman spectra of soft and hard PMX masses, suggesting the occurrence of calcification of HA in the PMX tissue, particularly in the hard PMX mass. The result indicates that the micro-Raman spectroscopy may provide a highly sensitive and specific method for identifying normal skin dermis and how it differs in chemical composition from different PMX tissues.

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Secondary Anetoderma Overlying Pilomatrixomas

Cited by 24 publications

References 7 publications

Psödobüllöz Anetodermik Pilomatrikoma

Psödobüllöz Anetodermik Pilomatrikoma

A Bullous Pilomatricoma Developed after Hepatitis-A Vaccination

Micro‐Raman spectroscopy used to identify and grade human skin pilomatrixoma

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