Secondary amenorrhoea due to Leydig cell tumour

El-Badrawy, Mohammad Khairy; Davies, Nicola

doi:10.1080/01443610500212088

Cited by 4 publications

(2 citation statements)

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“…Although the tumor with virilization and rarely associated massive ascites might look malignant clinically, the tumor might prove to be benign [12]. In young adult women with secondary amenorrhea, or in perimenopausal women with severe hyperandrogenism and virilization, Leydig cell tumor of the ovary should be considered [13,14]. Of the different markers that have been reported to stain ovarian stromal tumors, inhibin has proven to be the most helpful; immunostaining with calretinin has also being suggested as a sensitive marker [15,16].…”

Section: Discussionmentioning

confidence: 99%

An ovarian steroid cell tumor with virilization and hypothyroidism: a case report

Wang

Chen

et al. 2007

Gynecol Surg

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Steroid cell tumors are rare ovarian sex-cord stromal tumors with malignant potential. The majority of these tumors produce steroids with testosterone being the most common. The diagnosis of these rare tumors can be problematic especially in the case of a small nonpalpable ovarian tumor. A 41-year-old woman presented with the gradual onset of defeminization, mild hypothyroidism, and virilization. A physical examination revealed a relatively healthy woman with borderline hirsutism, clitoromegaly and adnexal fullness without a palpable tumor. Elevated serum levels of TSH and testosterone were found preoperatively. Five weeks after an oophorectomy, serum levels of TSH and testosterone returned to normal and menstruation returned. Nonpalpable virilizing ovarian steroid cell tumors may be difficult to diagnose. A careful study of the patient's history, the development of defeminization followed by virilization, and a "characteristic" ultrasonogram, can be helpful for diagnosis. Hormonal studies including thyroid function should also be considered in an ovarian steroid cell tumor.

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Section: Discussionmentioning

confidence: 99%

An ovarian steroid cell tumor with virilization and hypothyroidism: a case report

Wang

Chen

et al. 2007

Gynecol Surg

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“…Hirsutism is also a quite common challenge. A very important factor which allows deduction of the significance of this clinical image is the speed with which hirsutism occurs, and the testosterone plasma level 4 . In many cases of idiopathic hirsutism, the cause cannot be determined.…”

Section: Discussionmentioning

confidence: 99%

Secondary hypertension and hirsutism as a clinical manifestation of tumor duplicity

Fryšák¹,

Karásek²,

Hartmann³

et al. 2015

BIOMED PAP

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Background. The differential diagnosis of the pathogenetic causes of hirsutism in combination with hypertension is a challenge for clinicians. Methods and Results. This case report demonstrates a patient suffering from two hormonally active tumors -an adrenal adenoma with primary aldosteronism and a Leydig cell ovarian tumor with hyperandrogenism. The task of the authors was easier due to the perimenopausal age of the proband. Adrenal selective venous sampling was very helpful in the diagnosis of these active endocrine tumors. Both were resolved by a single laparoscopic surgery. Conclusion. The combination of the two described tumors is a unique clinical finding. The resolution using laparoscopy in a single procedure provided an elegant and efficient therapeutic approach.

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Hypothyroidism and hyperlipidemia with a virilizing ovarian steroid cell tumor, not otherwise specified

Tsai

Chen

Wei

et al. 2007

Gynecological Endocrinology

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Steroid cell tumors, not otherwise specified, are rare ovarian sex cord-stromal tumors with malignant potential. The majority of these tumors produce steroids, with testosterone being the most common. A 44-year-old woman with hypothyroidism and hyperlipidemia presented with abrupt onset of oligomenorrhea, progressive virilization as acne, hirsutism and clitoromegaly, and a non-palpable pelvic mass. The preoperatively elevated serum testosterone level returned to normal after salpingo-oophorectomy, and then menstrual flow became regular.

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Secondary amenorrhoea due to Leydig cell tumour

Cited by 4 publications

References 0 publications

An ovarian steroid cell tumor with virilization and hypothyroidism: a case report

An ovarian steroid cell tumor with virilization and hypothyroidism: a case report

Secondary hypertension and hirsutism as a clinical manifestation of tumor duplicity

Hypothyroidism and hyperlipidemia with a virilizing ovarian steroid cell tumor, not otherwise specified

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