Hypothyroidism and hyperlipidemia with a virilizing ovarian steroid cell tumor, not otherwise specified

Tsai, Horng-Jyh; Chen, Shu-Chen; Wei, Hsiao-Yun; Chen, Gin‐Den

doi:10.1080/09513590601137111

Cited by 8 publications

(11 citation statements)

References 13 publications

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“…The majority of steroid cell tumors have either benign or low-grade behavior [ 11 , 12 ]. Most are diagnosed at a younger age in an early stage, are small, and are hormonally inactive.…”

Section: Discussionmentioning

confidence: 99%

Symptomatic Cushing’s syndrome and hyperandrogenemia in a steroid cell ovarian neoplasm: a case report

Sedhom

Ohri

et al. 2016

J Med Case Reports

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BackgroundMalignant steroid cell tumors of the ovary are rare and frequently associated with hormonal abnormalities. There are no guidelines on how to treat rapidly progressive Cushing’s syndrome, a medical emergency.Case presentationA 67-year-old white woman presented to our hospital with rapidly developing signs and symptoms of Cushing’s syndrome secondary to a steroid-secreting tumor. Her physical and biochemical manifestations of Cushing’s syndrome progressed, and she was not amenable to undergoing conventional chemotherapy secondary to the debilitating effects of high cortisol. Her rapidly progressive Cushing’s syndrome ultimately led to her death, despite aggressive medical management with spironolactone, ketoconazole, mitotane, and mifepristone.ConclusionsWe report an unusual and rare case of Cushing’s syndrome secondary to a malignant steroid cell tumor of the ovary. The case is highlighted to discuss the complications of rapidly progressive Cushing’s syndrome, an underreported and often unrecognized endocrine emergency, and the best available evidence for treatment.

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“…The majority of steroid cell tumors have either benign or low-grade behavior [ 11 , 12 ]. Most are diagnosed at a younger age in an early stage, are small, and are hormonally inactive.…”

Section: Discussionmentioning

confidence: 99%

Symptomatic Cushing’s syndrome and hyperandrogenemia in a steroid cell ovarian neoplasm: a case report

Sedhom

Ohri

et al. 2016

J Med Case Reports

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“…The gross specimen shows a tumor with a clear boundary, almost always well circumscribed and solid, with an enveloped, lobulated or nodular appearance (24,25). A total of 94% of cases are unilateral, while 6% are bilateral (2).…”

Section: Discussionmentioning

confidence: 99%

“…A total of 94% of cases are unilateral, while 6% are bilateral (2). The average diameter of the tumor is 8.5 cm, and the cut surface is yellow or orange (25), with occasional bleeding or cystic degeneration. Microscopically, the tumor cells are round or polygonal, and medium-to-large in size with distinct cell borders.…”

Section: Discussionmentioning

confidence: 99%

“…The two types of cells differ only in their cytoplasmic appearance. The eosinophilic cells contain eosinophilic, slightly granular cytoplasm, while the clear cells have abundant vacuolated clear cytoplasm which is often positive for fat stains (2,16,20,25–27). In contrast to Leydig cells, the clear cells lack crystals of Reinke in the cytoplasm (26,27).…”

Section: Discussionmentioning

confidence: 99%

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A rare occurrence of a malignant ovarian steroid cell tumor not otherwise specified: A case report and literature review

Zhu

Xiong

et al. 2014

Oncology Letters

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Steroid cell tumors not otherwise specified (NOS) are a rare subgroup of sex cord-stromal tumors. The tumors can occur at any age, although the mean age of occurrence is 43 years old. The majority are benign, but have the capability of producing one or more steroids associated with virilization. The present study reports the case of a 29-year-old female who presented to the Second Xiangya Hospital suffering from lower back and leg pain that had persisted for five months. The patient had regular menstrual cycles and no virilization symptoms were present. Laboratory investigations revealed normal hormone levels. Multiple areas of bone destruction and a right ovarian mass were confirmed via positron emission tomography/computed tomography. The patient underwent an exploratory laparotomy, and a mass measuring ~6 cm in diameter was subsequently identified in the right ovary. A right salpingo-oophorectomy and pelvic washings for cytology were performed. Histopathological studies confirmed the diagnosis of a malignant steroid cell tumor NOS of the right ovary. The patient underwent eight cycles of chemotherapy (docetaxel, 120 mg and nedaplatin, 80 mg). The patient continued to have relatively good health, with no deterioration of the condition for one year and a half, however, the disease progressed and the patient succumbed to brain metastases six months later.

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“…About 6 months prior to seeing this patient, however, we encountered and then reported a patient with hypothyroidism and hyperlipidemia, associated with a virilizing ovarian steroid cell tumor. That patient had a 15-year history of hypothyroidism under fair control with thyroxine and an 8-year history of hyperlipidemia presenting with abrupt onset of oligomenorrhea, progressive virilization with elevated testosterone level, and a nonpalpable benign steroid cell tumor [4]. These two patients are the only two steroid cell tumors at this hospital, and both cases were associated with hypothyroidism.…”

Section: Discussionmentioning

confidence: 99%

An ovarian steroid cell tumor with virilization and hypothyroidism: a case report

Wang

Chen

et al. 2007

Gynecol Surg

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Steroid cell tumors are rare ovarian sex-cord stromal tumors with malignant potential. The majority of these tumors produce steroids with testosterone being the most common. The diagnosis of these rare tumors can be problematic especially in the case of a small nonpalpable ovarian tumor. A 41-year-old woman presented with the gradual onset of defeminization, mild hypothyroidism, and virilization. A physical examination revealed a relatively healthy woman with borderline hirsutism, clitoromegaly and adnexal fullness without a palpable tumor. Elevated serum levels of TSH and testosterone were found preoperatively. Five weeks after an oophorectomy, serum levels of TSH and testosterone returned to normal and menstruation returned. Nonpalpable virilizing ovarian steroid cell tumors may be difficult to diagnose. A careful study of the patient's history, the development of defeminization followed by virilization, and a "characteristic" ultrasonogram, can be helpful for diagnosis. Hormonal studies including thyroid function should also be considered in an ovarian steroid cell tumor.

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Hypothyroidism and hyperlipidemia with a virilizing ovarian steroid cell tumor, not otherwise specified

Cited by 8 publications

References 13 publications

Symptomatic Cushing’s syndrome and hyperandrogenemia in a steroid cell ovarian neoplasm: a case report

Symptomatic Cushing’s syndrome and hyperandrogenemia in a steroid cell ovarian neoplasm: a case report

A rare occurrence of a malignant ovarian steroid cell tumor not otherwise specified: A case report and literature review

An ovarian steroid cell tumor with virilization and hypothyroidism: a case report

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