Symptomatic Cushing’s syndrome and hyperandrogenemia in a steroid cell ovarian neoplasm: a case report

Abstract

BackgroundMalignant steroid cell tumors of the ovary are rare and frequently associated with hormonal abnormalities. There are no guidelines on how to treat rapidly progressive Cushing’s syndrome, a medical emergency.Case presentationA 67-year-old white woman presented to our hospital with rapidly developing signs and symptoms of Cushing’s syndrome secondary to a steroid-secreting tumor. Her physical and biochemical manifestations of Cushing’s syndrome progressed, and she was not amenable to undergoing conventional chemotherapy secondary to the debilitating effects of high cortisol. Her rapidly progressive Cushing’s syndrome ultimately led to her death, despite aggressive medical management with spironolactone, ketoconazole, mitotane, and mifepristone.ConclusionsWe report an unusual and rare case of Cushing’s syndrome secondary to a malignant steroid cell tumor of the ovary. The case is highlighted to discuss the complications of rapidly progressive Cushing’s syndrome, an underreported and often unrecognized endocrine emergency, and the best available evidence for treatment.

Recurrent ovarian steroid cell tumour not otherwise specified: A case report

“…It has been described to be used in ovarian steroid cell tumor with hypercortisolism, bearing a good response. 15 In conclusion, recurrent ovarian steroid cell tumor NOS is considered rare. This case shows how benign tumors can have malignant potential and present as a recurrent tumor.…”

“…It has been described to be used in ovarian steroid cell tumor with hypercortisolism, bearing a good response. 15 …”

Dual-tracer PET/CT imaging to determine tumor heterogeneity in a patient with metastatic ACTH-secreting neuroendocrine neoplasm: A case report and literature review

“…Cushing's syndrome is often associated with small cell lung cancer and pancreas and thymus NETs. The ACTH-producing NETs of other localizations, including the ovaries, are extremely rare (1)(2)(3)(4)(5)(6). Ovarian NETs account for only 0.1% of all ovarian neoplasms and less than 5% of all neuroendocrine tumors (7).…”

Tumor ovárico de células esteroideas sin otra especificación, durante el embarazo

“…Aproximadamente 25% de estos tumores no segregan hormonas. También existen informes de su asociación con el síndrome de Cushing, hipopotasemia, hipertensión e incluso casos relacionados con hipotiroidismo (6) . En vista de lo anterior, es necesario realizar un perfil hormonal completo para descartar cualquiera de estas patologías causadas por el tumor ovárico.…”