Second trimester maternal serum human chorionic gonadotropin and unconjugated oestriol levels in blacks and whites

Simpson, J. L.; Elias, Sherman; Morgan, CynthiaD.; Shulman, L.P.; Umstot, Ed; Andersen, Richard N.

doi:10.1016/0140-6736(90)91485-s

Cited by 24 publications

(15 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rawlins et al [11] reported that DIA Access and ELISA DIA precision (within-run CV, 3.9-5.3%; total CV, 3.9-5.4%) in our study was similar to that of Rawlins et al [11] (within-run CV, 3.2-3.6%; total CV, 4.1-4.2%) for similar levels ( have not been reported for Asians [16]. Our study showed similar median values for uE3.…”

Section: Discussionsupporting

confidence: 77%

See 1 more Smart Citation

Performance Characteristics of the UniCel DxI 800 Immunoassay for the Maternal Serum Quadruple Test, Including Median Values for Each Week of Gestation, in Korean Women

et al. 2010

View full text Add to dashboard Cite

Maternal serum prenatal quadruple screening includes tests for alpha-fetoprotein (AFP), human chorionic gonadotrophin (hCG), unconjugated estriol (uE3), and dimeric inhibin A (DIA). Measurements of maternal serum AFP, uE3, and hCG, as well as maternal age, are widely used in the second trimester for the identification of pregnancies at high risk of Down syndrome [1,2]. The maternal serum mid-trimester triple marker test is also a widely accepted protocol in Korea [3][4][5]. The triple test (AFP, uE3, hCG Background : Maternal serum prenatal quadruple screening includes testing for alpha-fetoprotein (AFP), human chorionic gonadotrophin (hCG), unconjugated estriol (uE3), and dimeric inhibin A (DIA). We evaluated quadruple screening using an automated platform and looked for any ethnic differences in the median values of each marker.Methods : We measured the concentrations of each quadruple test analyte using the UniCel DxI 800 system (Beckman Coulter, USA) in 788 Korean mid-trimester maternal serum samples and calculated their median values using Benetech software (Benetech, Canada). We also compared the results with those obtained using the Immulite 2000 assay (Siemens Healthcare Diagnostics, USA) or ELISA (DSL, USA) in 442 samples.Results : We obtained mid-trimester median values for each marker. The following are the comparative results for each test using the Immulite 2000 assay or ELISA (x) and the UniCel DxI 800 immunoassay (y): AFP, y=1.10x+0. 01, r=0.925; uE3, y=0.28x+0.24, r=0.885; hCG, r=0.944; and DIA, y=0.86x+15.31, r=0.833. Assay results for each of the four markers showed good correlations. However, significant biases necessitated new median calculations of prenatal risk estimates in all four tests.Conclusions : We established gestational age-specific second-trimester median values for four markers in Korean samples using the UniCel DxI 800 immunoassay system. Despite significant bias, there were good correlations between the results obtained using the UniCel DxI 800 immunoassay and those obtained using the Immulite 2000 assay. (Korean J Lab Med 2010;30:126-32)

show abstract

Section: Discussionsupporting

confidence: 77%

“…Passing-Bablok regression produced variable slopes ranging from 0.28 to The median values for each of the four markers at [15][16][17][18][19][20] weeks of gestations are presented in Table 2.…”

Section: Resultsmentioning

confidence: 99%

Performance Characteristics of the UniCel DxI 800 Immunoassay for the Maternal Serum Quadruple Test, Including Median Values for Each Week of Gestation, in Korean Women

et al. 2010

View full text Add to dashboard Cite

show abstract

“…In Japan, owing to the authors' endeavour, serum triple-marker screening has been offered to a number of pregnant Japanese women. There have been reports concerning racial differences in median values between Caucasian and black women (Simpson et al, 1990;Haddow et al, 1994). Similarly, we reported that medians of the three markers were higher in pregnant native Japanese women than in pregnant U.S. Caucasian women (Onda et al, 1994).…”

Section: Introductionmentioning

confidence: 55%

Agreement between predicted risk and prevalence of Down syndrome in second-trimester triple-marker screening in Japan

Onda

Tanaka

Takeda³

et al. 1998

Prenat. Diagn.

View full text Add to dashboard Cite

“…Such adjustment increases detec tion while decreasing the false-positive rate. The effect is less pronounced in Down syndrome screening, although higher hCG levels have also been reported in AfricanAmericans when compared with Caucasians [14,15]. A few studies have looked at Asian populations with similar findings of higher mid-trimester levels of hCG [16][17][18], O'Brien et al [ 17,18] looked at serum screening in a New York metropolitan area population, and found a consis tent pattern of analyte differences across all gestational ages, with highest values for all three analytes in Asians.…”

Section: Discussionmentioning

confidence: 93%

“…MoMs are adjusted for gestational age and maternal weight. The Baylor Prenatal Screening Program uses patient-specific Fetal Diagn Ther 1997;12:102-106 14.2% of Caucasians. Both differences are very unlikely to be due to chance (p < 0.001).…”

Section: Resultsmentioning

confidence: 99%

Effect of Hispanic Ethnicity on Interpretation of Maternal Serum Screening

Byrne

Waller²,

Rose

et al. 1997

Fetal Diagn Ther

View full text Add to dashboard Cite

Maternal serum concentrations of α-fetoprotein (MSAFP), unconjugated estriol (uE₃) and human chorionic gonadotropin (hCG) were measured in the sera of 3,046 Hispanic women and of 15,154 Caucasian women from gestational weeks 14 through 20 between January 1990 and December 1995. Median values for analytes were calculated for each gestational week and the two ethnic groups compared. Our findings indicate that the median values for Hispanics are lower for MSAFP and hCG, but higher for estriol. These differences are not accounted for by differences in median weights of the two ethnic groups. Although these results would suggest that Hispanic women at risk for a fetus with a neural tube defect (NTD) may be missed when cut-offs derived from a Caucasian population are used, in fact, that was not the case in our screening population. However, a disproportionate number of Hispanic women may be identified with an abnormal serum screening test unrelated to a risk for neural tube defects. This does not infer that detection rates are different across different ethnic groups since other factors are involved. Adjustment of medians for Hispanic ethnicity may have a small but significant effect, especially with regard to low values.

show abstract

Second trimester maternal serum human chorionic gonadotropin and unconjugated oestriol levels in blacks and whites

Cited by 24 publications

References 0 publications

Performance Characteristics of the UniCel DxI 800 Immunoassay for the Maternal Serum Quadruple Test, Including Median Values for Each Week of Gestation, in Korean Women

Performance Characteristics of the UniCel DxI 800 Immunoassay for the Maternal Serum Quadruple Test, Including Median Values for Each Week of Gestation, in Korean Women

Agreement between predicted risk and prevalence of Down syndrome in second-trimester triple-marker screening in Japan

Effect of Hispanic Ethnicity on Interpretation of Maternal Serum Screening

Contact Info

Product

Resources

About