Second Primary Cancers Following Female Breast Cancer in Osaka, Japan—A Population-Based Cohort Study

Murakami, Ryosuke; Hiyama, Tomohiko; Hanai, Aya; Fujimoto, Isaburo

doi:10.1093/oxfordjournals.jjco.a039211

Cited by 24 publications

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“…According to the results of the present study, breast cancer survivors among women and men have 27% and 28% extra risk of developing second primary cancers, respectively. This estimate is consistent with the reported risk in some previous studies among men ( 84 ) and women ( 10 , 41 , 59 , 63 ). Based on our results and previous studies ( 7 ), premenopausal women (younger than 50 years) are at a higher risk of the occurrence of second cancers.…”

Section: Discussionsupporting

confidence: 92%

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Risk of second primary cancer among breast cancer patients: A systematic review and meta-analysis

et al. 2023

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ObjectivesThe aim of this study was to estimate the extra risk of second primary cancer among breast cancer patients.Methods and materialsThis is a systematic review. A comprehensive search of literature was performed in PubMed, Web of Science, Cochrane library, and Scopus. The search included all published studies up to October 2022. This systematic review included studies published in the English language that reported the risk of second primary non-breast cancer [i.e., standardized incidence ratio (SIR)] among breast cancer patients older than 15 years. After evaluating the methodological quality of the selected studies, SIRs were pooled with consideration of heterogeneity among studies. The estimates were pooled by age and time since the diagnosis of primary breast cancer for both sexes (male and female). Age was categorized based on before 50 years and after 50 years, and time was categorized as duration of less than and more than 10 years, respectively.ResultsFrom 2,484 articles, 30 articles were eligible for inclusion in the systematic review and meta-analysis. The studies varied in terms of population, number of cases, study design, setting, and year of implementation of the research. The estimated SIR for men and women was 1.28 (95% CI: 1.18, 1.38) and 1.27 (95% CI: 1.15, 1.39), respectively. Women diagnosed with breast cancer before menopause [SIR: 1.52 (95% CI: 1.34, 1.71) vs. 1.21 (95% CI: 1.08, 1.34)] as well as women after 10 years since their breast cancer diagnosis [1.33 (95% CI: 1.22, 1.431) vs. 1.24 (95% CI: 1.10, 1.37)] were at a higher risk of developing second primary cancer. Among men, while there were no differences in risk based on age, with the increase of time, the risk of second primary cancer was reduced [SIR: 1.22 (95% CI: 1.12, 1.33) vs. 1.00 (95% CI: 0.79, 1.22)].ConclusionThere is an extra risk of second primary cancer among breast cancer patients. The extra risk should be considered for further screening and preventive measures among this population.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=336062, identifier (CRD42022336062).

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Section: Discussionsupporting

confidence: 92%

“…( 66 ), which was conducted on men. The methodological quality of the included articles was evaluated as high, except for the articles that were prone to misclassification bias ( 61 , 68 ) and/or selection bias ( 15 , 17 , 59 , 61 , 62 , 70 , 73 , 74 , 77 ).…”

Section: Resultsmentioning

confidence: 99%

Risk of second primary cancer among breast cancer patients: A systematic review and meta-analysis

et al. 2023

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Breast Cancer: Minimalists, Maximalists, Other Neoplasms

Cohen¹,

Somers²

1991

JAMA: The Journal of the American Medical Association

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A population-based study of contralateral breast cancer following a first primary breast cancer (Washington, United States)

Cook¹,

White²,

Schwartz³

et al. 1996

Cancer Causes Control

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To evaluate predictors of contralateral breast cancer risk, we examined data from a nested case-control study of second primary cancers among a cohort of women in western Washington (United States) diagnosed with breast cancer during 1978 through 1990 and identified through a population-based cancer registry. Cases included all women in the cohort who subsequently developed contralateral breast cancer at least six months after the initial diagnosis, but prior to 1992 (n = 234). Controls were sampled randomly from the cohort, matched to cases on age, stage, and year of initial breast cancer diagnosis. Information on potential risk factors for second primary cancer was obtained through medical record abstractions and physician questionnaires. Women who were postmenopausal due to a bilateral oophorectomy (i.e., a surgical menopause) at initial breast cancer diagnosis had a reduction in contralateral breast cancer risk compared with premenopausal women (matched odds ratio [mOR] = 0.25, 95 percent confidence interval [CI] = 0.09-0.68), whereas no reduction in risk was noted among postmenopausal women who had had a natural menopause (mOR = 0.90, CI = 0.39-2.09). Among postmenopausal women, there was a suggestion of a lower risk associated with relatively high parity (2+). A family history of breast cancer was associated with an increased risk (mOR = 1.96, CI = 1.22-5.15) and varied little by menopausal status. Having an initial tumor with a lobular component (c.f. a ductal histology) was not related strongly to risk (mOR = 1.47, CI = 0.79-2.74). The results of the present and earlier studies argue that we have limited ability to predict the occurrence of a contralateral breast tumor. Better predictors will be required before diagnostic and preventive interventions can be targeted to subgroups of patients with unilateral breast cancer.

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Second Primary Cancers Following Female Breast Cancer in Osaka, Japan—A Population-Based Cohort Study

Cited by 24 publications

References 0 publications

Risk of second primary cancer among breast cancer patients: A systematic review and meta-analysis

Risk of second primary cancer among breast cancer patients: A systematic review and meta-analysis

Breast Cancer: Minimalists, Maximalists, Other Neoplasms

A population-based study of contralateral breast cancer following a first primary breast cancer (Washington, United States)

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