Most studies on susceptible-infected-susceptible epidemics in networks implicitly assume Markovian behavior: the time to infect a direct neighbor is exponentially distributed. Much effort so far has been devoted to characterize and precisely compute the epidemic threshold in susceptible-infected-susceptible Markovian epidemics on networks. Here, we report the rather dramatic effect of a nonexponential infection time (while still assuming an exponential curing time) on the epidemic threshold by considering Weibullean infection times with the same mean, but different power exponent . For three basic classes of graphs, the Erdős-Rényi random graph, scale-free graphs and lattices, the average steady-state fraction of infected nodes is simulated from which the epidemic threshold is deduced. For all graph classes, the epidemic threshold significantly increases with the power exponents . Hence, real epidemics that violate the exponential or Markovian assumption can behave seriously differently than anticipated based on Markov theory. The epidemic threshold of a network distinguishes between the overall-healthy network regime and the effective infection regime where permanently a nonzero fraction of the nodes is infected. The epidemic threshold reflects the effectivity of an epidemic in a particular network and is a major indicator or tool to protect the nodes (people, computers, etc.) and to take preventive measures (governmental immunization strategies, antivirus software protection).Recently (see, e.g., Refs. [1][2][3][4][5][6][7]) much effort has been devoted to the precise computation of the epidemic threshold in the continuous-time susceptible-infected-susceptible (SIS) Markov model in networks. In that simple SIS model, the viral state of a node i at time t is specified by a Bernoulli random variable X i ðtÞ 2 f0; 1g: X i ðtÞ ¼ 0 for a healthy node and X i ðtÞ ¼ 1 for an infected node. A node i at time t can be in one of two states: infected, with probability v i ðtÞ ¼ Pr½X i ðtÞ ¼ 1 or healthy, with probability 1 À v i ðtÞ, but susceptible to the infection. The curing process per node i is a Poisson process with rate and the infection rate per link is a Poisson process with rate . Obviously, only when a node is infected, can it infect its direct neighbors that are still healthy. Both the curing and infection Poisson processes are independent. The network is represented by an adjacency matrix A, where a ij ¼ 1 if there is a link from node i to node j, otherwise a ij ¼ 0. A major complication in the SIS Markov model is the absorbing state to which the epidemic SIS process always converges after a sufficiently long time in any network G with a finite number N of nodes and L of links. Hence, the steady state is the overall-healthy (absorbing) state. Since the exact steady state is physically less meaningful, the epidemic threshold refers to the metastable or quasistationary state which is observed in practice. However, the metastable state needs to be defined (see, e.g., Refs. [4,8]).Since X i is a Bernoulli random ...