Second-order facial information processing in schizophrenia.

Baudouin, Jean‐Yves; Vernet, Mathilde; Franck, Nicolás

doi:10.1037/0894-4105.22.3.313

Cited by 13 publications

(4 citation statements)

References 51 publications

(50 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One possible explanation for the divergence in all previous studies is that those medicated patients displayed impairment in a selective type of configural manipulation (i.e., second-order information) but still relied on some degree of configuration information (i.e., first-order or thirdorder information), which explains why they still exhibited an inversion effect as did healthy controls (Chambon et al, 2006;Schwartz et al, 2002). In line with this, Baudouin et al (2008) demonstrated that patients specifically displayed impairment in the manipulation of second-order information, whereas thirdorder information processing was somewhat maintained.…”

Section: Discussionmentioning

confidence: 91%

Relation between facial affect recognition and configural face processing in antipsychotic-free schizophrenia.

Fakra¹,

Jouve²,

Guillaume³

et al. 2015

Neuropsychology

View full text Add to dashboard Cite

This study confirms the presence of a deficit in facial affect recognition, and also of dysfunctional manipulation in configural information in antipsychotic-free patients. Negative symptoms and poor processing of configural information explained a substantial part of the deficient recognition of facial affect. We speculate that this deficit may be caused by several factors, among which independently stand psychopathology and failure in correctly manipulating configural information.

show abstract

Section: Discussionmentioning

confidence: 91%

Relation between facial affect recognition and configural face processing in antipsychotic-free schizophrenia.

Fakra¹,

Jouve²,

Guillaume³

et al. 2015

Neuropsychology

View full text Add to dashboard Cite

show abstract

“…Irregularities in face processing are a common characteristic of some human neuropsychiatric conditions. Patients with schizophrenia, for example, have been shown to exhibit impairments in configural face processing (Baudouin et al, 2008;Joshua & Rossell, 2009;Shin et al, 2008) aberrant facial emotion processing (see for review Morris et al, 2009), and abnormal gaze patterns during face viewing, including avoidance of the eyes (Loughland et al, 2002;Phillips & David, 1998;Williams et al, 1999). Neural correlates of these impairments have been documented, including attenuated amplitudes for event related potential components associated with face processing (Feuerriegel et al, 2015;McCleery et al, 2015), and structural and functional abnormalities in face processing areas such as the fusiform gyrus (P. J.…”

Section: Introductionmentioning

confidence: 99%

Ketamine disrupts gaze patterns during face viewing in the common marmoset

Selvanayagam

Johnston

Wong

et al. 2021

Journal of Neurophysiology

View full text Add to dashboard Cite

Faces are stimuli of critical importance for primates. The common marmoset (Callithrix jacchus) is a promising model for investigations of face processing, as this species possesses oculomotor and face processing networks resembling those of macaques and humans. Face processing is often disrupted in neuropsychiatric conditions such as schizophrenia (SZ) and thus it is important to recapitulate underlying circuitry dysfunction preclinically. The N-Methyl-D-aspartate (NMDA) non-competitive antagonist ketamine has been used extensively to model the cognitive symptoms of SZ. Here, we investigated the effects of a subanesthetic dose of ketamine on oculomotor behaviour in marmosets during face viewing. Four marmosets received systemic ketamine or saline injections while viewing phase-scrambled or intact videos of conspecifics' faces. To evaluate effects of ketamine on scan paths during face viewing, we identified regions of interest in each face video, and classified locations of saccade onsets and landing positions within these areas. A preference for the snout over eye regions was observed following ketamine administration. In addition, regions in which saccades landed could be significantly predicted by saccade onset region in the saline but not the ketamine condition. No significant drug effects were observed for phase-scrambled videos. Effects on saccade control were limited to a reduction in saccade amplitudes during viewing of scrambled videos. Thus, ketamine induced a significant disruption of scan paths during viewing of conspecific faces but limited effects on saccade motor control. These findings support the use of ketamine in marmosets for investigating changes in neural circuits underlying social cognition in neuropsychiatric disorders.

show abstract

“…Here we looked into the development of this sensitivity by considering a new indicator of perceptual sensitivity, namely discriminability thresholds (i.e., the minimal feature spacing a participant is able to detect) at each age. The procedure and materials were the same as those used by Baudouin, Vernet, and Franck (2008) with schizophrenics, with 7-, 9-, and 11-year-olds and adults being asked to state whether the distance between the eyes was the same in two side-by-side faces. The two faces were the same except for the eye spacing.…”

Section: Introductionmentioning

confidence: 99%