Second malignant neoplasms in children treated for rhabdomyosarcoma. Intergroup Rhabdomyosarcoma Study Committee.

Heyn, Ruth; Haeberlen, Veronica; Newton, William A.; Ragab, Abdel; Raney, R. Beverly; Tefft, Melvin; Wharam, Moody D.; Ensign, Lisa G.; Maurer, Harold M.

doi:10.1200/jco.1993.11.2.262

Cited by 186 publications

(103 citation statements)

References 39 publications

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“…This has considerable implications for the clinical management of patients in Li-Fraumeni families, particularly in screening for cancers and for treatment. While the frequency of radiationinduced tumours is still not known in germline mutant TP53 carriers, there is evidence that second malignant neoplasms occur at a relatively high frequency in the radiation zone (Strong and Williams, 1987;Heyn et al, 1993), although more extensive studies must be carried out to confirm this. The relative contributions of genetic background and radiation remain to be evaluated in a careful epidemiological study.…”

Section: Functional Studies Of Li-fraumeni Cellsmentioning

confidence: 99%

“…This will probably have more implications for treatment of tumours than in prevention, but any procedure reducing mortality in Li-Fraumeni syndrome would be gratefully accepted by the families. There is a general assumption that tumours in carriers of germline TP53 mutations may be relatively radiation resistant, although hard data are not available and there appears to be a high risk of second malignancy in the radiation field (Strong and Williams, 1987;Heyn et al, 1993). However, more extensive longitudinal studies on germline TP53 mutation carriers are necessary to assess the effectiveness of current treatment regimens.…”

Section: Clinical Aspects Of Li-fraumeni Familiesmentioning

confidence: 99%

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Li-Fraumeni syndrome – a molecular and clinical review

Varley

Evans²,

Birch³

1997

Br J Cancer

318

180

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Section: Functional Studies Of Li-fraumeni Cellsmentioning

confidence: 99%

Section: Clinical Aspects Of Li-fraumeni Familiesmentioning

confidence: 99%

Li-Fraumeni syndrome – a molecular and clinical review

Varley

Evans²,

Birch³

1997

Br J Cancer

318

180

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“…A role for chem otherapy in treatment is yet to be established, and som e agents may increase the incidence of these rare tum ours. 21,91 …”

Section: Onclusionsmentioning

confidence: 99%

Should Cancer Survivors Fear Radiation‐Induced Sarcomas?

Feigen

1997

Sarcoma

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A bstractPurpose/Results. Ionizing radiation is carcinogenic and the induction of a second malignancy is a serious potential long-term complication of radiotherapy. The incidence of radiation-induced sarcomas was evaluated from many large epidemiological surveys of long-term cancer survivors reported in the literature over the past 30 years and only one case was found for every 1000 patients irradiated. D iscussion. Although greater numbers of cancer patients are receiving radical radiotherapy and surviving free of disease for longer intervals, cases of radiation-induced sarcomas are rare and should not deter patients from accepting radiotherapy as treatment for curable cancers. With improvements in the administration of radiotherapy over the past two decades which are resulting in less damage to bone and soft tissues, it is likely that fewer cases of this condition will be seen in the future. If these sarcomas are diagnosed early, long-term survival can be achieved with surgical excision and possibly re-irradiation, as occurs in other types of sarcomas.K ey w ords: radiation-induced sarcoma, bone sarcom a, soft tissue sarcom a.

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“…An increased risk of STS has been found in survivors of various types of childhood cancers, including retinoblastoma, leukaemia, Wilms' tumour, and Hodgkin's lymphoma (Breslow et al, 1995;Beaty et al, 1995;Moll et al, 1997;Neglia et al, 2001;Bisogno et al, 2004;Fletcher et al, 2004;Kleinerman et al, 2005). Also survivors of childhood STS, osteosarcoma, and Ewing sarcoma have been shown to be at increased risk of multiple primary malignancies, including bone sarcomas and STS (Heyn et al, 1993;Pratt et al, 1997;Neglia et al, 2001;Paulussen et al, 2001;Bacci et al, 2005;Cohen et al, 2005;Bassal et al, 2006). Development of multiple primary malignancies may also represent a side effect of chemotherapy or radiotherapy, which yield an increased risk of secondary malignancies, including STS (Brady et al, 1992;Kony et al, 1997;Neglia et al, 2001;Sheppard and Libshitz, 2001;Cormier and Pollock, 2004;Kirova et al, 2005;Thijssens et al, 2005;Virtanen et al, 2006).…”

mentioning

confidence: 99%

Increased risk of malignancies in a population-based study of 818 soft-tissue sarcoma patients

et al. 2006

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Soft-tissue sarcomas (STS) have been associated with various rare cancer syndromes and occur at increased frequencies in survivors of childhood cancer. Also adult patients with STS have been suggested to be at an increased risk of additional malignancies. After exclusion of syndrome-associated and radiation-induced sarcomas, we studied multiple primary malignancies in a population-based cohort of 818 patients with primary STS of the extremities and the trunk wall. In total, 203 other malignancies developed in 164 (20%) patients median 10 (0 -32) years before and median 4 (0 -35) years after the sarcoma diagnosis. Standardised morbidity ratios (SMRs) were determined for primary malignancies following a STS. Hereby individuals who had developed a STS were identified to be at increased risk of second primary malignancies (SMR for all malignant tumours ¼ 1.3; 95% CI ¼ 1.0 -1.5; P ¼ 0.02) with STS being the only specific tumour type that occurred at an increased risk (SMR ¼ 17.6; 95% CI ¼ 8.1 -33.5; Po0.001). Hence, this populationbased series demonstrates a high frequency of second primary tumours among STS patients and indicates a particularly increased risk of developing a new STS.

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Second malignant neoplasms in children treated for rhabdomyosarcoma. Intergroup Rhabdomyosarcoma Study Committee.

Cited by 186 publications

References 39 publications

Li-Fraumeni syndrome – a molecular and clinical review

Li-Fraumeni syndrome – a molecular and clinical review

Should Cancer Survivors Fear Radiation‐Induced Sarcomas?

Increased risk of malignancies in a population-based study of 818 soft-tissue sarcoma patients

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