Increased risk of malignancies in a population-based study of 818 soft-tissue sarcoma patients

Fernebro, Josefin; Bladström, Anna; Rydholm, Anders; Gustafson, Pelle; Olsson, Håkan; Engellau, Jacob; Nilbert, Mef

doi:10.1038/sj.bjc.6603401

Cited by 29 publications

(31 citation statements)

References 38 publications

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“…Soft tissue sarcomas (STS) are a heterogeneous group of rare mesenchymal tumors, accounting for approximately 1% of all adult malignancies . About 60% of all STS arise in the extremities .…”

Section: Introductionmentioning

confidence: 99%

Soft Tissue Sarcomas of the Extremities: Surgical Margins Can Be Close as Long as the Resected Tumor Has No Ink on It

et al. 2017

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In the present retrospective analysis of 643 patients with primary soft issue sarcomas of the extremities, surgical margins could be identified as independent predictors of local recurrence-free, disease-specific, and metastasis-free survival. Given the diminished outcome of patients left with positive margins, surgical efforts should aim to achieve microscopically negative margins whenever feasible. It is noteworthy that only the quality of surgical margins, but not the negative margin width attained, had an influence on the prognosis. Our findings suggest that surgical margins can be close as long as the resected tumor has no ink on it.

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Section: Introductionmentioning

confidence: 99%

Soft Tissue Sarcomas of the Extremities: Surgical Margins Can Be Close as Long as the Resected Tumor Has No Ink on It

et al. 2017

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“…Radiotherapy and chemotherapy are associated with an increased risk of developing a second malignant neoplasm. [15][16][17] In the present study, the preceding malignancy was treated by surgery alone in 11 of 21 cases. Five of 21 cases were treated by radiotherapy with or without surgery and chemotherapy.…”

Section: Discussionmentioning

confidence: 81%

The impact of antecedent primary malignancy in soft tissue sarcoma patients

Torigoe

Imanishi

Yazawa

et al. 2019

J Orthop Surg (Hong Kong)

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Background: It is unclear whether antecedent primary malignancies (APMs) have any negative impact on the prognosis of soft tissue sarcoma (STS). We retrospectively reviewed STS patients with APMs (STS-APM) and compared their survival to those of STS only (STS-O). Methods: Twenty-one cases of STS-APM from 2008 to 2017 in our institution were analyzed. One hundred and seventy cases of STS-O at the same period were compared as a control group. Overall survival was estimated using Kaplan-Meier survival curves and prognostic factors were analyzed using logistic regression analyses and contingency table analyses. Results: As the final status of STS-APM patients, 12 patients were in disease-free survival, 5 were alive with disease, 3 have died of disease, and 1 has died of another disease. There was no case that died of APM. The 5-year overall survival rates were 88% in STS-APM and 78% in STS-O, showing no statistical significant (p ¼ 0.65). The 5-year overall survival rates in each stage of STS-APM and STS-O were 100/100% in stage I, 100/85% in stage II, 86/72% in stage III, and the 3-year overall survival rates were 67/51% in stage IV, with no statistical significance. With regard to prognostic factor, histological grade of STS was the only significant factor. Although antecedent radiotherapy tended to show a high odds ratio, the association was not statistically significant. Antecedent chemotherapy did not show any estimated prognostic risk. Conclusions: Our study suggested that APM in STS patient would not be a negative prognostic factor.

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“…3,[13][14][15][16] This increased risk is either related to chemotherapy/radiotherapy 15,16 or attributed to the intrinsic predisposition to secondary malignancies in patients with primary neoplasms. 3 C, Survival analysis stratified by cytogenetic groups: the group with complex abnormalities, -5 or -7 vs the one with other abnormalities or normal karyotype.…”

Section: Discussionmentioning

confidence: 98%

Myeloid Neoplasms Secondary to Plasma Cell Myeloma: An Intrinsic Predisposition or Therapy-Related Phenomenon?

Reddi

Fedoriw

et al. 2012

Am J Clin Pathol

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We describe 41 cases of myeloid neoplasms (MNs) secondary to plasma cell myeloma (PCM). The types of MN included myelodysplastic syndrome (MDS) in 34 (82.9%), acute myeloid leukemia (AML) in 4 (9.8%), and myeloproliferative neoplasm (MPN) or MDS/MPN in 3 (7.3%) cases. The latency from treatment to diagnosis of MN ranged from 9 to 384 months, with a median of 60 months. Of 37 cases with cytogenetic studies, complex abnormalities were detected in 22 (59.5%), -5(q)/-7(q) in 4 (10.8%), other abnormalities in 8 (21.6%), and normal karyotype in 3 (8.1%) cases. Complex abnormalities and -5(q)/-7(q) correlated directly with multiple chemotherapeutic regimens, particularly with combined melphalan/cyclophosphamide. Moreover, the features of cytogenetic abnormalities in our series were significantly different from those with concomitant PCM/MN who had significantly lower complex abnormalities. The latency, skewed proportion of MDS, and bias toward complex cytogenetic abnormalities/unbalanced aberrations of chromosomes 5/7 suggested an alkylating mutagenic effect on pathogenesis of secondary MN. Kaplan-Meier survival analysis demonstrated a median survival of 19 months, which was better than that for therapy-related (t)-MDS/AML. In contrast to t-MDS, the survival in our patients appeared to depend on subtypes of MDS as seen in de novo diseases.

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Increased risk of malignancies in a population-based study of 818 soft-tissue sarcoma patients

Cited by 29 publications

References 38 publications

Soft Tissue Sarcomas of the Extremities: Surgical Margins Can Be Close as Long as the Resected Tumor Has No Ink on It

Soft Tissue Sarcomas of the Extremities: Surgical Margins Can Be Close as Long as the Resected Tumor Has No Ink on It

The impact of antecedent primary malignancy in soft tissue sarcoma patients

Myeloid Neoplasms Secondary to Plasma Cell Myeloma: An Intrinsic Predisposition or Therapy-Related Phenomenon?

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