Second-generation Platelet Concentrate (Platelet-rich Fibrin) as a Scaffold in Regenerative Endodontics: A Case Series

Bakhtiar, Hengameh; Esmaeili, Shahram; Tabatabayi, Setareh Fakhr; Ellini, Mohammad Reza; Nekoofar, Mohammad Hossein; Dummer, P. M. H.

doi:10.1016/j.joen.2016.10.016

Cited by 84 publications

(90 citation statements)

References 48 publications

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“…, Bakhtiar et al . ) have been used as a scaffold instead of a blood clot because PRP and PRF are rich in growth factors, which might help improve regeneration of pulp–dentine complex. However, a systematic review of clinical studies of platelet concentrations in revitalization of immature necrotic teeth demonstrated that PRP or PRF was not significantly superior to a blood clot in promoting thickening of the canal walls/continued root development in RET (Lolato et al .…”

Section: Blood Clotmentioning

confidence: 99%

Regenerative endodontics: a comprehensive review

et al. 2018

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The European Society of Endodontology and the American Association for Endodontists have released position statements and clinical considerations for regenerative endodontics. There is increasing literature on this field since the initial reports of Iwaya et al. (Dental Traumatology, 17, 2001, 185) and Banchs & Trope (Journal of Endodontics, 30, 2004, 196). Endogenous stem cells from an induced periapical bleeding and scaffolds using blood clot, platelet rich plasma or platelet-rich fibrin have been utilized in regenerative endodontics. This approach has been described as a 'paradigm shift' and considered the first treatment option for immature teeth with pulp necrosis. There are three treatment outcomes of regenerative endodontics; (i) resolution of clinical signs and symptoms; (ii) further root maturation; and (iii) return of neurogenesis. It is known that results are variable for these objectives, and true regeneration of the pulp/dentine complex is not achieved. Repair derived primarily from the periodontal and osseous tissues has been shown histologically. It is hoped that with the concept of tissue engineering, namely stem cells, scaffolds and signalling molecules, that true pulp regeneration is an achievable goal. This review discusses current knowledge as well as future directions for regenerative endodontics. Patient-centred outcomes such as tooth discolouration and possibly more appointments with the potential for adverse effects needs to be discussed with patients and parents. Based on the classification of Cvek (Endodontics and Dental Traumatology, 8, 1992, 45), it is proposed that regenerative endodontics should be considered for teeth with incomplete root formation although teeth with near or complete root formation may be more suited for conventional endodontic therapy or MTA barrier techniques. However, much is still not known about clinical and biological aspects of regenerative endodontics.

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Section: Blood Clotmentioning

confidence: 99%

Regenerative endodontics: a comprehensive review

et al. 2018

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“…Recently, a synthetic polymer polycaprolactone was successful in growing increasing numbers of stem cells from apical papilla stem cells with apparent identification of NOTCH signaling expression. [23][24][25][26] Although the number of scaffolds has increase questions remain that must be addressed.…”

Section: Scaffoldsmentioning

confidence: 99%

“…The peptide system is referred to as a tunable matrix with several features that possibly allow scaffolds to be designed, as different requirements are needed to regenerate a tissue. [10,[25][26][27][28] …”

Section: Scaffoldsmentioning

confidence: 99%

Future prospects in endodontic regeneration - A review article

Mookhtiar¹,

Hegde²,

Shanmugsundaram³

2018

IDJAR

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“…osteochondral lesions, synovial knee joint failure, acute diaphyseal fractures of the femur, trauma, maxillofacial defects, periodontal tissue augmentation, peripheral nerve injuries, chondral lesions of the hip, wound, degenerative disc disease, femoral neck fractures, oral peri-implant defects, and hair loss [28][29][30][31][32][33][34][35][36][37][38][39][40][41][42].…”

Section: Platelet-rich Plasmamentioning

confidence: 99%

“…Additionally, autologous PRP may play a role in improving femoral neck fractures [39]. A pre-clinical experiment demonstrated that the use of PRP in conjunction with MSC can ameliorate oral peri-implant defects [40]. PRP is also able to impact the growth-inhibitory activities of pathogenic bacteria [29].…”

Section: Platelet-rich Plasmamentioning

confidence: 99%

Mesenchymal Stem Cells and Platelet Derived Concentrates in Regenerative Medicine

Sheykhhasan

2017

JSRT

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In the recent years, the unique characteristics of mesenchymal stem cells (MSCs), consisting their angiogenesis and vascularization activity, as well as anti-inflammatory, anti-ulcer and immunosuppressive features plusdifferentiation capability into multilineage cell, have provided huge favorite among clinicians and researchers that theirs experiments has focused on treatment of different diseases. Additionally, Platelet-derived concentrates, including platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), are remarkably being utilized for lesion healing. In this article, we will be discussed a mini-review on the some of the application of mesenchymal stem cells and platelet derived concentrates in regenerative medicine.

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Second-generation Platelet Concentrate (Platelet-rich Fibrin) as a Scaffold in Regenerative Endodontics: A Case Series

Cited by 84 publications

References 48 publications

Regenerative endodontics: a comprehensive review

Regenerative endodontics: a comprehensive review

Future prospects in endodontic regeneration - A review article

Mesenchymal Stem Cells and Platelet Derived Concentrates in Regenerative Medicine

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