Mesenchymal Stem Cells and Platelet Derived Concentrates in Regenerative Medicine

Abstract

In the recent years, the unique characteristics of mesenchymal stem cells (MSCs), consisting their angiogenesis and vascularization activity, as well as anti-inflammatory, anti-ulcer and immunosuppressive features plusdifferentiation capability into multilineage cell, have provided huge favorite among clinicians and researchers that theirs experiments has focused on treatment of different diseases. Additionally, Platelet-derived concentrates, including platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), are remarkably being utilized for lesion healing. In this article, we will be discussed a mini-review on the some of the application of mesenchymal stem cells and platelet derived concentrates in regenerative medicine.

Mesenchymal stem cells as a valuable agent in osteoarthritis treatment

“…Additionally, many difficulties are encountered in autologous chondrocyte implantation for cartilage regeneration, such as donor site damage and cell limited life span after transplantation (4,5). These problems make new therapeutic methods, such as regenerative medicine, to repair the damaged cartilage tissue an exciting prospect (6).…”

“…Mesenchymal stem cells (MSCs), as a suitable cell source, are considered as novel therapeutic agents for cartilage and bone diseases and injuries because of their special ability to differentiate into a variety of cell types and their potent capability to self-renewal and repair, as well as their high healing ability and their growth factor secretory capacity (6). MSCs have been identified in many tissues, including bone marrow, adipose tissue, and synovial tissue (6). In addition, because lack of human leucocyte antigen (HLA) class II expression, mesenchymal stem cells are also able to retain immunomodulatory activity in vivo (7).…”