Secoisolariciresinol diglucoside inhibits adipogenesis through the AMPK pathway

Kang, JongWook; Park, Jin Bong; Kim, Hye-Lin; Jung, Yoon Suk; Youn, Dong‐Hyun; Lim, Seona; Song, Gahee; Park, Hyewon; Jin, Jong Sik; Kwak, Hyun Jeong; Um, Jae‐Young

doi:10.1016/j.ejphar.2017.12.038

Cited by 19 publications

(12 citation statements)

References 44 publications

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“…Because of estrogen agonist or antagonist properties, flaxseed and its lignan precursor, SDG, affect pregnancy outcome or reproductive development in rats [ 52 ]. Moreover, SDG inhibits adipogenesis by activating AMPK α , suggesting it could be an attractive therapeutic candidate for the treatment of obesity [ 53 ]. We know that fat metabolism and reproduction are associated with aging [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

Secoisolariciresinol Diglucoside Delays the Progression of Aging-Related Diseases and Extends the Lifespan ofCaenorhabditis elegansvia DAF-16 and HSF-1

Tan

Zhou

et al. 2020

Oxidative Medicine and Cellular Longevity

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Secoisolariciresinol diglucoside (SDG) is a phytoestrogen and rich in food flaxseed, sunflower seeds, and sesame seeds. Among the beneficial pharmacological activities of SDG on health, many are age related, such as anticancer, antidiabetes, antioxidant, and neuroprotective effects. Thus, we investigated if SDG had an effect on antiaging in Caenorhabditis elegans (C. elegans). Our results showed that SDG could extend the lifespan of C. elegans by up to 22.0%, delay age-related decline of body movement, reduce the lethality of heat and oxidative stress, alleviate dopamine neurodegeneration induced by 6-hydroxydopamine (6-OHDA), and decrease the toxicity of Aβ protein in C. elegans. SDG could increase the expression of the downstream genes of DAF-16, DAF-12, NHR-80, and HSF-1 at mRNA level. SDG could not extend the lifespan of mutants from genes daf-16, hsf-1, nhr-80, daf-12, glp-1, eat-2, and aak-2. The above results suggested that SDG might enhance the stress resistance, delay the progression of aging-related diseases, and extend the lifespan of C. elegans via DAF-16 and HSF-1.

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Section: Discussionmentioning

confidence: 99%

Secoisolariciresinol Diglucoside Delays the Progression of Aging-Related Diseases and Extends the Lifespan ofCaenorhabditis elegansvia DAF-16 and HSF-1

Tan

Zhou

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…Equol is a secondary metabolite of the soy isoflavone daidzein that is produced by intestinal bacteria, which is approximately produced by 30% of the population but shows the strongest binding affinity and estrogenic activities, especially for ERβ (estrogen receptor beta). , Plant lignans are present in foods such as whole grains, seeds and nuts, and fruits and vegetables . Secoisolariciresinol, a typical lignan present in the human diet, exists abundantly in flaxseeds . Its metabolites, enterolactone and enterodiol, are produced by microorganisms in the colon and can affect estrogen’s function in the body .…”

Section: Introductionmentioning

confidence: 99%

Detection of Phytoestrogen Metabolites in Breastfed Infants’ Urine and the Corresponding Breast Milk by Liquid Chromatography–Tandem Mass Spectrometry

Min

Wang

Liang

et al. 2020

J. Agric. Food Chem.

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To date, there has been limited information on phytoestrogen (PE) exposure and metabolism in breastfed infants. In the present work, 50 sample pairs of Chinese breastfed infants’ urine and the corresponding breast milk were collected. The contents of the relevant PE metabolites in the biosamples were detected via liquid chromatography–tandem mass spectrometry. The correlations between the PE metabolite contents in breastfed infants’ urine and those in the corresponding breast milk were analyzed. The average concentrations of total PE metabolites in breast milk and urine were 0.27 and 0.23 nmol/mL, respectively. Genistein and enterolactone levels in the infant urine were positively correlated with their concentrations in the corresponding breast milk samples, which implies that urine excretion can be utilized as a noninvasive parameter for precise genistein and enterolactone intake assessment. Additionally, the efficiency of PE urine excretion showed significant differences across infants with different ages, genders, and durations of pregnancy.

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“…In a clinical study, Zhang et al reported that a daily supplement of 600 mg SDG for 8 weeks in patients with hypercholesterolemia reduces plasma total cholesterol, low-density lipoprotein cholesterol, and fasting blood glucose levels [46]. Kang et al reported that supplementation with SDG (50 mg/kg/d) inhibits fat formation in obese mice induced by a high-fat diet by reducing Ppar protein expression [47]. Pan et al further demonstrated the beneficial effects of SDG in a randomized, double-blind trial of 68 patients with type 2 diabetes who were given 360 mg of SDG daily for 12 weeks.…”

Section: Discussionmentioning

confidence: 99%

Secoisolariciresinol Diglucoside Regulates Adipose Tissue Metabolic Disorder in Obese Mice Induced by a Western Diet

Dong

Bai

Chen

et al. 2021

Journal of Food Quality

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Secoisolariciresinol diglucoside (SDG) is the main component of flax lignans. Current studies have reported a positive effect of SDG on obesity and metabolic diseases. SDG has strong blood fat- and blood sugar-lowering, anti-inflammatory, and antioxidant effects and prevents heart disease and other chronic diseases. In this study, we explored the effects of SDG on Western diet-induced obesity and lipid metabolic disorder. Supplementing Western diet-induced obese mice with 40 mg kg1 d1, SDG for 12 weeks significantly reduced body and tissue weights. Increased adiponectin levels and decreased serum leptin and resistin levels were observed in obese mice orally administered SDG. Proliferation of adipose tissue was observed by hematoxylin and eosin staining, and cell size was quantitatively analyzed. As a result, SDG inhibited the proliferation of adipose tissue. In addition, SDG suppressed the mRNA expression of lipid synthetic genes and upregulated the mRNA expression of lipolytic genes. Overall, these results indicate that SDG inhibits obesity induced by a Western diet and regulates adipose tissue metabolic disorder. These results provide a theoretical basis for further study on the regulation of obesity and lipid metabolic disorder caused by SDG.

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Secoisolariciresinol diglucoside inhibits adipogenesis through the AMPK pathway

Cited by 19 publications

References 44 publications

Secoisolariciresinol Diglucoside Delays the Progression of Aging-Related Diseases and Extends the Lifespan ofCaenorhabditis elegansvia DAF-16 and HSF-1

Secoisolariciresinol Diglucoside Delays the Progression of Aging-Related Diseases and Extends the Lifespan ofCaenorhabditis elegansvia DAF-16 and HSF-1

Detection of Phytoestrogen Metabolites in Breastfed Infants’ Urine and the Corresponding Breast Milk by Liquid Chromatography–Tandem Mass Spectrometry

Secoisolariciresinol Diglucoside Regulates Adipose Tissue Metabolic Disorder in Obese Mice Induced by a Western Diet

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