Seborrheic keratosis

Hafner, Christian; Vogt, Thomas

doi:10.1111/j.1610-0387.2008.06788.x

Cited by 169 publications

(265 citation statements)

References 11 publications

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“…Their incidence increases with age and old individuals can have many lesions (Fig. S1A), occasionally displaying a linear distribution; little is known about their etiology (1). SK are classified in three histological subtypes (acanthotic, hyperkeratotic, and adenoid; Fig.…”

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confidence: 99%

Multiple oncogenic mutations and clonal relationship in spatially distinct benign human epidermal tumors

Hafner

Toll

Fernández-Casado

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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Malignant tumors result from the accumulation of genetic alterations in oncogenes and tumor suppressor genes. Much less is known about the genetic changes in benign tumors. Seborrheic keratoses (SK) are very frequent benign human epidermal tumors without malignant potential. We performed a comprehensive mutational screen of genes in the FGFR3-RAS-MAPK and phosphoinositide 3-kinase (PI3K)-AKT pathways from 175 SK, including multiple lesions from each patient. SK commonly harbored multiple bona fide oncogenic mutations in FGFR3, PIK3CA, KRAS, HRAS, EGFR, and AKT1 oncogenes but not in tumor suppressor genes TSC1 and PTEN. Despite the occurrence of oncogenic mutations and the evidence for downstream ERK/MAPK and PI3K pathway signaling, we did not find induction of senescence or a DNA damage response. Array comparative genomic hybridization (aCGH) analysis revealed that SK are genetically stable. The pattern of oncogenic mutations and X chromosome inactivation departs significantly from randomness and indicates that spatially independent lesions from a given patient share a clonal relationship. Our findings show that multiple oncogenic mutations in the major signaling pathways involved in cancer are not sufficient to drive malignant tumor progression. Furthermore, our data provide clues on the origin and spread of oncogenic mutations in tissues, suggesting that apparently independent (multicentric) adult benign tumors may have a clonal origin.

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confidence: 99%

Multiple oncogenic mutations and clonal relationship in spatially distinct benign human epidermal tumors

Hafner

Toll

Fernández-Casado

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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“…Seborrheic keratosis is one of the most common benign epidermal cutaneous lesions encountered by dermatologists and plastic surgeons in their daily practice [1,2] .…”

Section: Introductionmentioning

confidence: 99%

“…A clonality analysis had shown that the majority of lesions are monoclonal tumours and have true autonomous growth, but without chromosomal instability. The growth of the epidermal cells are arrested at the G1 phase, hence maintaining its biologically benign nature [1] . Various authors had reported a concomi-tant occurrence of malignant growth associated with seborrheic keratosis, although without strong association of it [4][5][6][7][8][9] .…”

Section: Introductionmentioning

confidence: 99%

“…Unusually large-sized seborrheic keratoses are rarely reported, and their clinical significance is largely unknown. The majority of lesions occur in multiplicity with sizes less than 3 cm, and they can usually be removed with non-surgical options [1] . Baer emphasised that the lesions can become very large and he published a case of giant seborrheic keratosis with the size of 5.5 × 3.5 cm at the inguinal region [3] .…”

Section: Introductionmentioning

confidence: 99%

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Giant seborrheic keratosis of the face – an unusual presentation

2016

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Seborrheic keratosis is the most common benign epidermal lesion in the world, especially among the elderly. Its inherent benign nature has precluded the need to remove it for medical reasons. Most of the concerns presented to dermatologists or plastic surgeons are of cosmetic reasons, besides some unusual appearances that necessitate cutaneous malignancy evaluation. Unusually large sizes of seborrheic keratosis are rarely reported, and its clinical significance is largely unknown. It has been proven by recent molecular studies that seborrheic keratosis is true neoplasia rather than a mere epidermal hyperplasia, and various authors have reported several cases of concomitant malignancy arising from seborrheic keratosis. Plastic surgeon expertise is often required when faced with an extensive lesion, requiring reconstructive procedures to preserve good aesthetic and functional outcomes. The purpose of this review is to report a case of an unusually large seborrheic keratosis on the face, highlighting its clinical relevance and surgical management.

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“…[1][2][3] Çoğunlukla erkeklerde görülür. 1 Patogenezi tam olarak bilinmeyen hastalığın histopatolojisinde, karakteristik kilise kulesi şeklinde epidermal hiperplazi görül-mektedir. 3,4 Literatürde stukko keratozun dermoskopik özellikleri fazla çalışılmamıştır.…”

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