Seborrheic keratoses: A study comparing the standard cryosurgery with topical calcipotriene, topical tazarotene, and topical imiquimod

Abstract

Cryosurgery produces clinical and histological improvement of seborrheic keratoses. The result with cryosurgery was cosmetically acceptable to all patients. Responders to tazarotene cream 0.1% found it cosmetically acceptable.

Seborrheic keratosis

“…However, one‐fourth of lesions failed to adequately respond to topical therapy. In another study, tazarotene 0.1% in a cream base, applied twice daily, achieved complete resolution (confirmed on histology) in 7 of 15 patients, although the drug caused considerable irritation [10]. Imiquimod was found in the same study to be ineffective.…”

Seborrhoeic keratosis removal in a multicentre phase I/II clinical trial using a novel topical formulation (BL-5010)

“…conducted a study in which the standard cryosurgery was compared with topical calcipotriene, tazarotene and imiquimod in patients with SK. Daily application of the three substances did not result in clinical improvement . Twice‐daily application of tazarotene caused clinical and histological improvement in seven of 15 patients, but was associated with burning, pruritus and redness.…”

Successful treatment of multiple seborrheic keratoses using acitretin

“…were not able to conclude whether SKs regressed after control of cutaneous inflammation or as a result of etretinate therapy. Application of topical retinoic acid may be beneficial in the treatment of SK, although cryosurgery has proved more effecient 5 …”