Sebaceus naevi: a clinicopathologic study

Muñoz‐Pérez, M.A.; Garcia-Hernandez, M. J.; Rios, J. J.; Camacho, Francisco Miguel

doi:10.1046/j.1468-3083.2002.00543.x

Cited by 49 publications

(57 citation statements)

References 33 publications

(48 reference statements)

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“…Nevus sebaceus (NS) is a congenital hamartoma that combines a variety of epidermal, hair follicle, sebaceous, and apocrine gland abnormalities. NS is detected in 0.5–1% of all dermatologic patients . It often presents at birth but may not become apparent until later in life.…”

Section: Introductionmentioning

confidence: 99%

Nevus sebaceus: a clinicopathological study of 168 cases and review of the literature

et al. 2015

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Section: Introductionmentioning

confidence: 99%

Nevus sebaceus: a clinicopathological study of 168 cases and review of the literature

et al. 2015

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“…Nevus sebaceus (NS), first described by Jadassohn, is a complex hamartoma usually found on the face or scalp and exhibits alopecia with epidermal hyperplasia, malformed hair follicle, sebaceous and ectopic apocrine glands to varying degrees microscopically. It may evolve through three stages clinically, including alopecia stage, verrucous or papillomatous plaque stage, and tumor stage 1 . In 2008, Correale et al.…”

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Large, papillomatous and pedunculated nevus sebaceus

Lin¹,

Lee²,

Shieh³

et al. 2010

The Journal of Dermatology

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“…2 Studies of large numbers of NS found syringocystadenoma papilliferum and trichoblastoma/basal cell carcinoma to be the most common. [3][4][5] Less frequent neoplasms reported include leiomyoma, 6 spiradenoma, 7 eccrine syringofibroadenoma, 8 follicular hybrid cysts, 9 squamous cell carcinoma, 10 sebaceous carcinoma, 11,12 tricholemmal carcinoma, 13 syringocystadenocarcinoma papilliferum, 14 eccrine porocarcinoma, 15 ductal sweat gland carcinoma, 16 and apocrine carcinoma. 10,17,18 We report a case of an adenocarcinoma with subsequent metastasis arising in association with a NS with multiple neoplastic proliferations.…”

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Metastasizing Adenocarcinoma and Multiple Neoplastic Proliferations Arising in a Nevus Sebaceus

Kantrow¹,

Ivan²,

Williams³

et al. 2007

The American Journal of Dermatopathology

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Nevus sebaceus of Jadassohn is a hamartoma of multiple skin structures. Many neoplasms have been reported to arise in association with nevus sebaceus, most commonly trichoblastoma/basal cell carcinoma and syringocystadenoma papilliferum. We report a case of a 66-year-old woman with an adenocarcinoma as well as multiple neoplastic proliferations arising in a long standing nevus sebaceus on the scalp, with subsequent occipital neck metastatic disease. On histologic evaluation, the epidermis showed changes reminiscent of tumor of the follicular infundibulum as well as basaloid proliferations resembling superficial trichoblastoma. A focus suggestive of syringofibroadenoma was also present. A small dermal collection of basaloid and more mature sebocytes was consistent with a sebaceoma/sebaceous epithelioma. Most of the lesion was composed of an adenocarcinoma with areas showing ductal differentiation with decapitation secretion, well-formed papillae and focal cribriform structures. Other portions demonstrated a high-grade neoplasm with prominent nuclear atypia and a solid pattern of growth resembling high-grade breast carcinoma. Anti-epithelial membrane antigen strongly labeled tumor cells and highlighted ductal structures. Less than 1% of cells expressed progesterone or estrogen receptors. Her2/neu reactivity was focally present, showing 1+ membranous reactivity in 10% of cells. Anti-p63 labeled basaloid cells surrounding the tumor lobules. A breast primary was ruled out by clinical and radiologic examination. This report illustrates an extraordinary case of adnexal neoplasia displaying various lines of differentiation arising in association with nevus sebaceus.

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Sebaceus naevi: a clinicopathologic study

Abstract: The incidence of malignancy arising on SN was very low, indicating that prophylactic surgery of NS in children is not recommendable. Developmental defects should be investigated in order to evidence possible epidermal naevus syndrome associated with SN.

Cited by 49 publications

References 33 publications

Nevus sebaceus: a clinicopathological study of 168 cases and review of the literature

Nevus sebaceus: a clinicopathological study of 168 cases and review of the literature

Large, papillomatous and pedunculated nevus sebaceus

Metastasizing Adenocarcinoma and Multiple Neoplastic Proliferations Arising in a Nevus Sebaceus

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